INvestigations In Gout, Hyperuricemia, and comorbidiTies (INSIGHT) Center of Research Translation (CORT)

痛风、高尿酸血症和合并症的调查 (INSIGHT) 研究翻译中心 (CORT)

• 批准号: 9902085
• 负责人: Kenneth G Saag
• 金额: $ 96.11万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9902085
• 关键词: Absenteeism; Academic Medical Centers; Accident and Emergency department; Acute; Address; Adenosine Monophosphate; Adult; Affect; African American; Alabama; Basic Science; Biological; Biological Markers; Biomedical Research; Biometry; California; Caring; Chronic; Chronic Disease; Chronic Kidney Failure; Clinical Data; Clinical Informatics; Clinical Trials; Communities; Comorbidity; Computerized Medical Record; Continuity of Patient Care; Deep South; Development; Diabetes Mellitus; Disease Progression; Doctor of Philosophy; Early identification; Educational Intervention; Emergency Department-based Intervention; Emergency Medicine; Enrollment; Environmental Risk Factor; Epidemic; Epidemiology; Face; Flare; Fostering; Frequencies; Funding; Future; Genes; Genetic; Genetic Translation; Goals; Gout; Health; Healthcare; Healthcare Systems; Heart Diseases; Hyperuricemia; Incidence; Inflammatory; Inflammatory Arthritis; Infrastructure; Institution; Interdisciplinary Study; International; Internet; Intervention; Investigation; Kidney Diseases; Knowledge; Laboratories; Link; Mediating; Medical; Metabolic syndrome; Methodology; Methods; Minority; Minority Participation; Mission; Modernization; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural Language Processing; Nephrology; Obesity; Outcome; Patient Care; Patient Education; Patients; Persons; Pharmaceutical Preparations; Phenotype; Population; Premature Mortality; Prevalence; Productivity; Protein Kinase; Quality of life; Recommendation; Registries; Renal function; Reporting; Research; Research Methodology; Research Personnel; Research Project Grants; Resources; Rheumatology; Sampling; Serum; Specimen; System; Techniques; Testing; Time; Training; Translational Research; Universities; Urate; Work; aging population; base; biobank; clinically relevant; functional genomics; gene environment interaction; genome wide association study; health care service utilization; health disparity; improved; innovation; men; metabolomics; minority health; multidisciplinary; novel; personalized medicine; precision medicine; productivity loss; recruit; tool; translational research program; translational scientist; urate transporter

Project Summary Gout impacts around 4% of the U.S. adult population and is the most common form of inflammatory arthritis in men. The incidence of gout is increasing worldwide. Gout significantly burdens the healthcare system, and is associated with both decreased work productivity and quality of life. With the ever-increasing impact of gout and its associated comorbidities on the population, investigation of novel translational mechanisms mediating gout flares as well as approaches to improving gout and hyperuricemia outcomes comprise an unmet and urgent medical need. When funded, the INvestigationS In Gout, Hyperuricemia, and comorbidiTies (INSIGHT) Center of Research Translation (CORT) included 4 active research projects and an Administrative Core focused on the theme, “Gout, Hyperuricemia, and Associated Comorbidities”. Projects include studies to: determine if adenosine monophosphate-activated protein kinase (AMPK) activity metabolomics have promise as gout biomarkers independent of serum urate (P1), examine the influence of key gene-environment interactions within an internet study of gout flares (P2), unravel the functional genomics of urate transporter genes identified in previously reported genome wide association studies (P3), and investigate the mechanism of urate lowering therapy on renal function within VA STOP-GOUT (P4). Projects range from basic research translation of underlying genetics and inflammatory pathobiology of gout, to understanding mechanisms of CKD progression in gout, and translation of genetic interaction with environmental factors and medications, to precision medicine. The proposed revision project (P5) aims to utilize a novel emergency department based intervention to test methods to improve the care gout patients in the Deep South, with a secondary goal of concurrently enhancing participation of minorities in research. The revised INSIGHT CORT aims to: (1) Conduct five outstanding, innovative, and synergistic research projects drawing on the unique strengths of multidisciplinary research teams at our four major centers: University of Alabama at Birmingham, Harvard University, University of California San Diego, and now Vanderbilt University Medical Center; (2) Foster the development of pilot and feasibility projects and the development and application of new translational methods to research in gout and hyperuricemia and their associated major comorbidities, particularly CKD and metabolic syndrome; and (3) Promote training of translational investigators in current methods of research applicable to gout and hyperuricemia through enrichment activities overseen by our Administrative Core. The proposed revision project directly ties to the CORT through patient enrollment into the Gout CORT Registry and Biorepository, which contributes clinical data and biological samples to projects. The INSIGHT CORT is a multi-disciplinary translational research program at UAB and partner institutions. We have assembled an outstanding team and are uniquely prepared and strongly committed to scientific rigor, innovation, and development of knowledge and translational techniques.

项目摘要 痛风影响约4％的美国成年人口，是最常见的炎症性关节炎形式 男人。痛风的事件在全球范围内增加。痛风大大燃烧了医疗保健系统，并且是 与降低的工作生产力和生活质量有关。随着痛风的不断影响 及其相关的合并症在人群中，调查了新型翻译机制的调查 痛风的耀斑以及改善痛风和高尿酸症结果的方法 紧急医疗需求。资助后，痛风，高尿酸血症和合并症的调查 （见识）研究翻译中心（Cort）包括4个活跃的研究项目和一个 行政核心的重点是“痛风，高尿酸血症和相关合并症”。 项目包括：确定腺苷单磷酸激活蛋白激酶（AMPK）活性是否的研究 代谢组学有望成为独立于血清尿酸盐（P1）的生物标志物（P1），检查的影响 互联网研究中的关键基因环境相互作用（P2），解开功能基因组 在先前报道的基因组广泛关联研究（P3）中鉴定的尿酸盐转运蛋白基因， 研究尿酸盐降低治疗对VA停止术中肾功能的机制（P4）。项目 范围从基础研究的基础研究翻译的基础研究遗传学和痛风炎症病理学的翻译到 了解痛风中CKD进展的机制，以及遗传相互作用与与 环境因素和药物，用于精确医学。拟议的修订项目（P5）旨在 利用一种新型的基于急诊部门的干预措施来测试方法来改善痛风患者 深南方的次要目标是同时增强少数群体参与研究。这 修订后的Insight Cort的目的是：（1）进行五个杰出，创新和协同研究项目 利用我们四个主要中心的多学科研究团队的独特优势：大学 阿拉巴马州伯明翰，哈佛大学，加利福尼亚大学圣地亚哥分校和现在的范德比尔特大学 医疗中心； （2）促进飞行员和可行性项目的发展以及开发以及 新的翻译方法在痛风和高尿液中的研究及其相关的主要专业 合并症，特别是CKD和代谢综合征； （3）促进翻译调查人员的培训 在当前适用于痛风和高尿酸血症的研究方法中，通过由 我们的行政核心。拟议的修订项目直接通过患者注册与Cort联系 痛风Cort注册表和生物库，为项目贡献临床数据和生物样品。 Insight Cort是UAB和合作伙伴机构的多学科翻译研究计划。我们 已经组建了一支杰出的团队，并为科学严谨而做出了独特的准备，并致力于 知识和翻译技术的创新和发展。