Chemical Analysis Core

化学分析核心

• 批准号: 10352971
• 负责人: PAUL M STEMMER
• 金额: $ 6.82万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-08 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10352971
• 关键词: Address; Air; Animal Model; Awareness; Biological; Biological Assay; Biomedical Research; Chemicals; Chronic; Cities; Data Science; Detection; Discipline; Disease; Dose; Educational workshop; Emerging Technologies; Ensure; Environmental Engineering technology; Environmental Exposure; Environmental Health; Evaluation; Experimental Designs; Exposure to; Geographic Locations; Health; Human; Immunoassay; Industrialization; Inflammation; Inflammation Mediators; Informatics; Knowledge; Laboratory Personnel; Laboratory Research; Leadership; Mass Spectrum Analysis; Measurement; Measures; Methods; Microfluidics; Mission; Molecular; Monitor; Outcome; Pathway interactions; Peptides; Persons; Physiological; Plant Roots; Post-Translational Protein Processing; Postdoctoral Fellow; Premature Birth; Preparation; Property; Protein Analysis; Proteins; Proteome; Proteomics; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Risk; Sampling; Science; Services; Soil; Superfund; System; Techniques; Technology; Testing; Time; Toxic effect; Training; Uncertainty; Work; adduct; analytical method; base; biomarker discovery; cohort; community engagement; cost; cytokine; design; experimental study; exposed human population; graduate student; ground water; high throughput analysis; innovation; instrument; instrumentation; monitoring device; multidisciplinary; new technology; next generation; novel; novel strategies; offspring; pollutant; population based; residence; response; sensor; small molecule; urban area; vapor intrusion; volatile organic compound

SUMMARY/ABSTRACT: Exposure to volatile organic compounds (VOCs) is an important determinant of maternal-offspring health, with implications for preterm birth and associated adverse health outcomes. VOCs contaminate shallow soils and groundwater of post-industrial cities at Superfund, residential, commercial, and industrial properties, leading to exposure via vapor intrusion. The Center for Leadership in Environmental Awareness and Research (CLEAR) is dedicated to understanding and mitigating this serious environmental health problem. The Chemical Analysis Core (CAC) will create a comprehensive toolbox to quantitate, monitor, and determine the extent of VOC exposure for CLEAR research projects and the Community Engagement Core (CEC). The CAC supports CLEAR’s mission by providing analytical knowledge, guidance, training and new technologies designed to detect, assess and mitigate the adverse health effects emanating from chronic and low-level exposure to VOCs. The CAC leadership and laboratory personnel will work with and within the CLEAR project teams to ensure sensitive, accurate analyses and develop advanced techniques for VOC analysis in novel matrices as required. Specifically, the CAC will offer precise, sensitive, low cost, high volume quantification of VOC molecules and their metabolites, which are known or suspected to impact health. Proteomic and adductomic analyses will identify markers of environmental exposures as well as the extent of disease. Targeted and untargeted VOC analyses, proteomic, and adductomic workflows, which are available to investigators through partnership with the CAC, is tailored for each of the five CLEAR projects and the CEC. For each, analytical quantification of unique samples and new innovative sample preparation methods are an expected outcome. The CAC integrates small molecule mass spectrometry, proteomic mass spectrometry and high throughput cytokine analysis. These complementary analytical technologies enable the CAC to be integrated into CLEAR research projects and facilitate assessment of the degree of exposure and VOC exposure impacts on human health.

总结/摘要：暴露于挥发性有机化合物（VOC）是 母婴健康，对早产和相关的不良健康后果的影响。VOCs 污染浅层土壤和后工业城市的地下水在超级基金，住宅，商业， 工业性质，导致通过蒸汽侵入暴露。环境领导中心 意识和研究（CLEAR）致力于了解和减轻这一严重的环境问题。 健康问题。化学分析核心（CAC）将创建一个全面的工具箱，以定量，监测， 并确定CLEAR研究项目和社区参与的VOC暴露程度 核心（CEC）。CAC支持CLEAR的使命，提供分析知识、指导、培训和 旨在检测、评估和减轻慢性疾病对健康的不利影响的新技术 和低浓度的挥发性有机化合物CAC领导层和实验室人员将与 CLEAR项目团队确保敏感、准确的分析，并开发挥发性有机化合物的先进技术 根据需要在新基质中进行分析。具体来说，CAC将提供精确、灵敏、低成本、高容量的 量化已知或怀疑影响健康的VOC分子及其代谢物。 蛋白质组学和内收组织学分析将确定环境暴露的标志物以及 疾病目标和非目标VOC分析、蛋白质组学和内收体学工作流程，可用于 通过与食典委的合作，为五个CLEAR项目和CEC中的每一个项目量身定制了一个调查员培训计划。 对于每一个，独特样品的分析定量和新的创新样品制备方法都是一个重要的方面。 预期的结果。CAC集成了小分子质谱、蛋白质组质谱和 高通量细胞因子分析这些互补的分析技术使CAC能够 纳入CLEAR研究项目，并促进对接触程度和挥发性有机化合物的评估 暴露对人类健康的影响。