Chemical Analysis Core

摘要/摘要：接触挥发性有机化合物(VOCs)是 母子健康，对早产和相关不良健康后果的影响。VOCs 污染后工业城市的浅层土壤和地下水，如Superfund、住宅、商业和 工业特性，导致通过蒸汽侵入而暴露。环境领导中心 意识和研究(Clear)致力于了解和缓解这种严重的环境问题 健康问题。化学分析核心(CAC)将创建一个全面的工具箱来量化、监测 并确定明确研究项目和社区参与的VOC暴露程度 核心(CEC)。CAC通过提供分析知识、指导、培训和 旨在检测、评估和减轻慢性疾病对健康的不利影响的新技术 以及低水平接触挥发性有机化合物。CAC领导层和实验室人员将与 明确项目团队，确保对VOC进行敏感、准确的分析并开发先进的技术 根据需要使用新的矩阵进行分析。具体地说，CAC将提供精确、灵敏、低成本、大容量 对已知或怀疑影响健康的VOC分子及其代谢物进行量化。 蛋白质组学和内吸切分析将确定环境暴露的标志以及 疾病。有针对性和无针对性的VOC分析、蛋白质组和内收工作流程，可用于 调查人员通过与食典委的合作，为五个CLEAR项目和CEC中的每一个项目量身定做。 对于每一种方法，独特样品的分析量化和新的创新样品制备方法都是一种 预期结果。CAC集小分子质谱学、蛋白质组学和蛋白质组学于一体 高通量细胞因子分析。这些互补的分析技术使食典委能够 纳入明确的研究项目，促进对暴露程度和VOC的评估 暴露会对人类健康产生影响。

SUMMARY/ABSTRACT: Exposure to volatile organic compounds (VOCs) is an important determinant of maternal-offspring health, with implications for preterm birth and associated adverse health outcomes. VOCs contaminate shallow soils and groundwater of post-industrial cities at Superfund, residential, commercial, and industrial properties, leading to exposure via vapor intrusion. The Center for Leadership in Environmental Awareness and Research (CLEAR) is dedicated to understanding and mitigating this serious environmental health problem. The Chemical Analysis Core (CAC) will create a comprehensive toolbox to quantitate, monitor, and determine the extent of VOC exposure for CLEAR research projects and the Community Engagement Core (CEC). The CAC supports CLEAR’s mission by providing analytical knowledge, guidance, training and new technologies designed to detect, assess and mitigate the adverse health effects emanating from chronic and low-level exposure to VOCs. The CAC leadership and laboratory personnel will work with and within the CLEAR project teams to ensure sensitive, accurate analyses and develop advanced techniques for VOC analysis in novel matrices as required. Specifically, the CAC will offer precise, sensitive, low cost, high volume quantification of VOC molecules and their metabolites, which are known or suspected to impact health. Proteomic and adductomic analyses will identify markers of environmental exposures as well as the extent of disease. Targeted and untargeted VOC analyses, proteomic, and adductomic workflows, which are available to investigators through partnership with the CAC, is tailored for each of the five CLEAR projects and the CEC. For each, analytical quantification of unique samples and new innovative sample preparation methods are an expected outcome. The CAC integrates small molecule mass spectrometry, proteomic mass spectrometry and high throughput cytokine analysis. These complementary analytical technologies enable the CAC to be integrated into CLEAR research projects and facilitate assessment of the degree of exposure and VOC exposure impacts on human health.