Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of Psychopathology

西北大学心理健康，早期：精神病理学神经发育机制的跨诊断、跨学科、转化培训项目

• 批准号: 10205465
• 负责人: Stewart Aaron Shankman
• 金额: $ 24.62万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10205465
• 关键词: Mental Health; Psychopathology; Training Programs; Universities

Project Summary This T32 proposal will establish an innovative transdisciplinary postdoctoral training program focusing on transdiagnostic, neurodevelopmental mechanisms of psychopathology, with an expanded focus on developmental and environmental influences - program title: Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of Psychopathology (NU-MHE). Specifying malleable neurodevelopmental mechanisms of psychopathology at key developmental inflection points has proven elusive, suggesting that innovative methods and frameworks are necessary in order to advance intervention and prevention efforts. Approaches like NIMH’s Research Domain Criteria (RDoC) initiative, frame mental disorders as neurodevelopmental phenomena which emerge during an unfolding sequence from vulnerability to clinical symptomatology. This has led to novel research heuristics and designs which move away from conventional, discrete disease-based models towards more multi-level, transdiagnostic, transdisciplinary, approaches. However, the field is lacking training paradigms that effectively capture this dynamic, multi-faceted nature. This T32 thus proposes a novel training paradigm that bridges research in neurodevelopmental mechanisms of mental disorder with adjacent domains of high translational significance. Fellows will develop expertise in neurodevelopmental mechanisms of psychopathology, taking into account developmental and environmental contexts. Additionally, fellows will acquire foundational knowledge in the following core competencies: (1) computational psychiatry and other data science applications to mental health, (2) intervention/prevention/implementation science, (3) intersection of mental health and pediatric physical conditions – as well as the following professional development competencies, (4) translational team science, (5) ethical and responsible conduct of clinical research (which includes attentiveness to diversity), (6) grantsmanship, supporting a K or R-level grant submission, and (7) leadership and other career development skills. To achieve these competencies, at least 85% of the fellows’ time will be spent in mentored independent research. All fellows will have two co-mentors: A co-mentor with expertise in neurodevelopmental mechanisms of psychopathology; and a co-mentor in one of the following areas: (a) prevention, intervention, or implementation, (b) computational psychiatry and data science, or (c) the intersection of mental and pediatric health. These research experiences will be complemented by seminars in neurodevelopmental mechanisms of psychopathology, data science/computational psychiatry, as well as experiential learning (e.g., research in the context of real world care). Fellows will also make use of the rich educational resources available at NU, including professional development training in grant writing, team science skills, mentoring others, rigor and reproducibility, and other resources dedicated to career development. NU-MHE is well-positioned to launch the next generation of neurodevelopmental clinical scientists and leaders poised to accelerate the pace of clinical translation.

项目概要 该T32提案将建立一个创新的跨学科博士后培训项目，重点关注 精神病理学的跨诊断、神经发育机制，重点关注 发展和环境影响 - 项目名称：西北大学心理健康，早期： 神经发育机制跨诊断、跨学科、转化培训项目 精神病理学（NU-MHE）。明确精神病理学的可塑性神经发育机制 事实证明，关键的发展拐点难以捉摸，这表明创新方法和框架是 为推进干预和预防工作所必需的。 NIMH 的研究领域等方法 标准 (RDoC) 倡议将精神障碍定义为在发育过程中出现的神经发育现象 从脆弱性到临床症状的展开顺序。这导致了新颖的研究启发法和 设计从传统的、离散的基于疾病的模型转向更多层次、 跨诊断、跨学科的方法。然而，该领域缺乏有效的培训范式 捕捉这种动态、多面的本质。因此，这个 T32 提出了一种新颖的训练范式，可以将 高翻译邻近域精神障碍神经发育机制研究 意义。研究员将发展精神病理学神经发育机制方面的专业知识，并考虑到 考虑发展和环境背景。此外，研究员还将获得以下方面的基础知识： 以下核心能力：（1）计算精神病学和其他数据科学在心理方面的应用 健康，(2) 干预/预防/实施科学，(3) 心理健康与儿科的交叉 身体条件 – 以及以下专业发展能力，(4) 翻译团队 科学，(5) 临床研究的道德和负责任的行为（包括对多样性的关注），(6) 资助，支持 K 或 R 级资助申请，以及 (7) 领导力和其他职业发展 技能。为了获得这些能力，研究员至少 85% 的时间将花在受指导的独立项目上 研究。所有研究员将有两名共同导师： 一名具有神经发育机制专业知识的共同导师 精神病理学；以及以下领域之一的共同导师：(a) 预防、干预或 实施，(b) 计算精神病学和数据科学，或 (c) 心理和儿科的交叉 健康。这些研究经验将通过神经发育机制研讨会得到补充 精神病理学、数据科学/计算精神病学以及体验式学习（例如， 现实世界护理的背景）。研究员还将利用国立大学丰富的教育资源，包括 资助写作、团队科学技能、指导他人、严谨性和可重复性方面的专业发展培训， 以及其他致力于职业发展的资源。 NU-MHE 已做好准备推出下一代产品 神经发育临床科学家和领导者准备加快临床转化的步伐。