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Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of Psychopathology

西北大学心理健康，早期：精神病理学神经发育机制的跨诊断、跨学科、转化培训项目

基本信息

批准号：
10617249
负责人：
Stewart Aaron Shankman
金额：
$ 29.5万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10617249
关键词：
Diagnostic Mental Health Psychopathology Training Programs Universities

项目摘要

Project Summary This T32 proposal will establish an innovative transdisciplinary postdoctoral training program focusing on transdiagnostic, neurodevelopmental mechanisms of psychopathology, with an expanded focus on developmental and environmental influences - program title: Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of Psychopathology (NU-MHE). Specifying malleable neurodevelopmental mechanisms of psychopathology at key developmental inflection points has proven elusive, suggesting that innovative methods and frameworks are necessary in order to advance intervention and prevention efforts. Approaches like NIMH’s Research Domain Criteria (RDoC) initiative, frame mental disorders as neurodevelopmental phenomena which emerge during an unfolding sequence from vulnerability to clinical symptomatology. This has led to novel research heuristics and designs which move away from conventional, discrete disease-based models towards more multi-level, transdiagnostic, transdisciplinary, approaches. However, the field is lacking training paradigms that effectively capture this dynamic, multi-faceted nature. This T32 thus proposes a novel training paradigm that bridges research in neurodevelopmental mechanisms of mental disorder with adjacent domains of high translational significance. Fellows will develop expertise in neurodevelopmental mechanisms of psychopathology, taking into account developmental and environmental contexts. Additionally, fellows will acquire foundational knowledge in the following core competencies: (1) computational psychiatry and other data science applications to mental health, (2) intervention/prevention/implementation science, (3) intersection of mental health and pediatric physical conditions – as well as the following professional development competencies, (4) translational team science, (5) ethical and responsible conduct of clinical research (which includes attentiveness to diversity), (6) grantsmanship, supporting a K or R-level grant submission, and (7) leadership and other career development skills. To achieve these competencies, at least 85% of the fellows’ time will be spent in mentored independent research. All fellows will have two co-mentors: A co-mentor with expertise in neurodevelopmental mechanisms of psychopathology; and a co-mentor in one of the following areas: (a) prevention, intervention, or implementation, (b) computational psychiatry and data science, or (c) the intersection of mental and pediatric health. These research experiences will be complemented by seminars in neurodevelopmental mechanisms of psychopathology, data science/computational psychiatry, as well as experiential learning (e.g., research in the context of real world care). Fellows will also make use of the rich educational resources available at NU, including professional development training in grant writing, team science skills, mentoring others, rigor and reproducibility, and other resources dedicated to career development. NU-MHE is well-positioned to launch the next generation of neurodevelopmental clinical scientists and leaders poised to accelerate the pace of clinical translation.

项目总结

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neurodevelopmental vulnerability to psychosis: developmentally-based methods enable detection of early life inhibitory control deficits that predict psychotic-like experiences at the transition to adolescence.

神经发育对精神病的脆弱性：基于发育的方法能够检测早期生命的抑制控制缺陷，从而预测向青春期过渡时的类似精神病的经历。

DOI：
10.1017/s003329172300171x
发表时间：
2023
期刊：
Psychological medicine
影响因子：
6.9
作者：
Zarubin,VanessaC;Damme,KatherineSF;Vargas,Teresa;Osborne,KJuston;Norton,ElizabethS;Briggs-Gowan,Margaret;Allen,NorrinaB;Wakschlag,Laurie;Mittal,VijayA
通讯作者：
Mittal,VijayA

Low physical activity is associated with two hypokinetic motor abnormalities in psychosis.

DOI：
10.1016/j.jpsychires.2021.11.014
发表时间：
2022-03
期刊：
Journal of psychiatric research
影响因子：
4.8
作者：
Walther S;Vladimirova I;Alexaki D;Schäppi L;Damme KSF;Mittal VA;Shankman SA;Stegmayer K
通讯作者：
Stegmayer K

Physical and Mental Health in Adolescence: Novel Insights from a transdiagnostic examination of FitBit data in the ABCD Study.

青春期的身心健康：ABCD 研究中 FitBit 数据跨诊断检查的新见解。

DOI：
10.21203/rs.3.rs-3270112/v1
发表时间：
2023
期刊：
Research square
影响因子：
0
作者：
Damme,Katherine;Vargas,Teresa;Walther,Sebastian;Shankman,Stewart;Mittal,Vijay
通讯作者：
Mittal,Vijay

Perinatal depression in transgender and gender expansive individuals.

跨性别者和性别扩张个体的围产期抑郁症。