The Stanford-SLAC CryoEM Center
斯坦福大学-SLAC 冷冻电镜中心
基本信息
- 批准号:10615525
- 负责人:
- 金额:$ 37.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-05-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AdministratorAdoptedAdvisory CommitteesArchivesCollaborationsComputer softwareComputersCryo-electron tomographyCryoelectron MicroscopyDataData CollectionDepartment of EnergyDepositionDevelopmentEducational CurriculumEducational workshopElectron MicroscopeElectron MicroscopyElectronsEnvironmentEvaluationFeedbackGenerationsGeographic LocationsGeographyHealthHomeHumanImageInfrastructureInstitutionInternationalLaboratoriesLearningLightMapsMetadataMethodsModelingOnline SystemsPersonsPhysicsPreparationProcessProfessional OrganizationsProtocols documentationReadinessRequest for ApplicationsResearchResearch PersonnelResearch Project GrantsResearch TrainingResolutionResourcesRoentgen RaysRunningSamplingScientistShipsSourceSpecialistSpecimenStructural BiologistStructureSynchrotronsSystemTechniquesTechnologyThree-Dimensional ImageTimeTrainingTraining ProgramsUniversitiesValidationatomic databasecomputer clustercomputer infrastructurecomputing resourcescontrast imagingcryogenicsdata acquisitiondata exchangedata qualitydata repositorydata streamsdetectorelectron diffractionexperiencefollow-upfree-electron laserimage archival systemimage processinginnovationinstrumentmeetingsnext generationoperationpeerpreservationprogramsprospectiveprotein data bankrecruitresidenceresponsestructural biologytheoriestool
项目摘要
Project Summary
Stanford University and the SLAC National Accelerator Laboratory (SLAC) propose to host a
National Center for Cryogenic electron Microscopy – The Stanford-SLAC CryoEM Center (S2C2)
– to meet the emerging national need for cryoEM as a tool for atomic-resolution structural
biology. The proposed S2C2 will (1) establish and keep at the forefront, state-of-the-art cryo-
electron microscopes to satisfy users’ needs for atomic-resolution image data, (2) archive image
data with appropriate metadata, (3) provide computing resources to assess data quality in real
time, (4) inform and recruit potential users across the U.S. about the public accessibility of the
Center, (5) establish an open, fair, transparent and efficient process to select user proposals
based on scientific impact and specimen readiness, regardless of users’ geographic locations or
affiliations, (6) help users to overcome technical hurdles and enable them to obtain high-
resolution cryoEM structures quickly with a rigorous validation protocol, (7) form and facilitate a
user network to exchange information seamlessly, (8) train users to become independent
cryoEM investigators, (9) integrate user and trainee feedback into a continuous loop of facility
enhancement, and (10) optimize operations to achieve the above tasks effectively and
efficiently. Dr. Wah Chiu, the Contact PI, has decades of experience developing high-resolution
cryoEM technologies and directing research and training enterprises across multiple institutions.
Drs. Michael Schmid and Britt Hedman, also PIs of the Center, bring complementary expertise
in cryoEM, structural biology, and management and operation of large-scale national user
facilities. A Center Director of Operations, three skilled cryoEM specialists, a technical assistant,
and a user facility administrator will carry out the S2C2’s day-to-day operations, including data
collection, quality assessment, and cross-training. This S2C2 will reside in a new building at
SLAC. It will leverage SLAC’s expertise in serving thousands of users each year at its renowned
X-ray synchrotron and free electron laser user facilities. An Advisory Committee composed of
external expert scientists as well as user representatives will provide advice regarding S2C2
operations and development. Our Center will build on the unique strengths and support from
Stanford and SLAC, and will create a unique environment that combines high throughput
cryoEM data generation with training the next generation of cryoEM scientists.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Wah Chiu其他文献
Wah Chiu的其他文献
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{{ truncateString('Wah Chiu', 18)}}的其他基金
Cryo-ET Structural Biology of Herpesvirus Infection and Morphogenesis In Situ.
疱疹病毒感染和原位形态发生的 Cryo-ET 结构生物学。
- 批准号:
10192472 - 财政年份:2021
- 资助金额:
$ 37.84万 - 项目类别:
Cryo-ET Structural Biology of Herpesvirus Infection and Morphogenesis In Situ.
疱疹病毒感染和原位形态发生的 Cryo-ET 结构生物学。
- 批准号:
10352451 - 财政年份:2021
- 资助金额:
$ 37.84万 - 项目类别:
Stanford-SLAC CryoET Specimen Preparation Service Center (SCSC)
斯坦福-SLAC CryoET 标本制备服务中心 (SCSC)
- 批准号:
10818212 - 财政年份:2020
- 资助金额:
$ 37.84万 - 项目类别:
Stanford-SLAC CryoET Specimen Preparation Service Center (SCSC)
斯坦福-SLAC CryoET 标本制备服务中心 (SCSC)
- 批准号:
10588756 - 财政年份:2020
- 资助金额:
$ 37.84万 - 项目类别:
Stanford-SLAC CryoET Specimen Preparation Service Center (SCSC) Supplement
斯坦福-SLAC CryoET 标本制备服务中心 (SCSC) 补充资料
- 批准号:
10265915 - 财政年份:2020
- 资助金额:
$ 37.84万 - 项目类别:
Stanford-SLAC CryoET Specimen Preparation Service Center (SCSC)
斯坦福-SLAC CryoET 标本制备服务中心 (SCSC)
- 批准号:
10264893 - 财政年份:2020
- 资助金额:
$ 37.84万 - 项目类别:
Stanford-SLAC CryoET Specimen Preparation Service Center (SCSC)
斯坦福-SLAC CryoET 标本制备服务中心 (SCSC)
- 批准号:
10473758 - 财政年份:2020
- 资助金额:
$ 37.84万 - 项目类别:
Stanford-SLAC CryoET Specimen Preparation Service Center (SCSC)
斯坦福-SLAC CryoET 标本制备服务中心 (SCSC)
- 批准号:
10054621 - 财政年份:2020
- 资助金额:
$ 37.84万 - 项目类别:
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