Azheimer's Disease Risk and Ethnic Factors: the Case of Arab Americans- Administrative Supplement for Increased Costs

增加的费用补充-阿尔茨海默病的风险和种族因素：以阿拉伯人为例

Increased Costs Supplement- Alzheimer's Disease Risk and Ethnic Factors: The Case of Arab Americans This application for a NIA Administrative Supplement is requested to address the unprecedented cost increases arising from the two-year delay that followed the COVID-19 mandatory face-to-face data collection shutdown. We note that there has been no change in the original funded scope of the project Alzheimer's Disease Risk and Ethnic Factors: The Case of Arab Americans (R01AG057510). Despite the delay, no intervening research has reduced the importance or uniqueness of the proposed study, which will significantly advance our knowledge of racial/ethnic disparities in Alzheimer's disease (AD) and immigrant health through its focus on a severely underrepresented population. This project will also provide currently unavailable Arabic instruments and normative data that will assist both researchers and clinicians in the assessment of Mild Cognitive Impairment (MCI) and AD in Arab Americans. The specific aims are to: 1) Characterize cognition and AD risk among Arab Americans in metro-Detroit; 2) Determine the contribution of immigrant factors to cognition and AD risk among older Arab Americans; 3) Identify aspects of social networks that have greatest effects on cognition and AD risk. This supplement is submitted to preserve the integrity of the originally approved objectives, purpose and expected overall impact of the study. The two-year COVID delay hit this pioneering study especially hard and has been financially devastating. Making Arab Americans visible in AD research epitomizes NIA's strategic directions related to AD disparities, as it will provide the first data on MCI and AD prevalence in a regionally representative sample of Arab Americans. Arab Americans are disproportionately underrepresented in research yet valuable to advancing knowledge related to health disparities. Further, the planned sample identification and data collection of this project's original scope form the foundation of two separately funded R01 studies (see Fig.1); completion of which hinges on this additional funding request. Project deliverables will include critical assessment tools that do not currently exist, refined understanding of AD disparities and immigrant health, and key information to effectively manage this growing and high-cost disease in diverse older adults.