Organ Design and Engineering Training Program (ODET Program)

器官设计与工程培训项目（ODET项目）

• 批准号: 10681212
• 负责人: JOSEPH VINCENT BONVENTRE
• 金额: $ 41.08万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10681212
• 关键词: Engineering; Organ; Training Programs; design

The number of available organs for transplantation is severely limited by a shortage of donors. Regenerative medicine has emerged as a field that brings the potential of designing and creating artificial organs, or parts of organs, closer to reality. To develop functional tissue requires applying concepts in tissue engineering and molecular/developmental biology in innovative ways. This requires a new type of scientist who has been well-trained in the concepts and methods at the interfaces of engineering and the molecular/developmental biology disciplines. Successfully integrating these approaches could dramatically catalyze the formation of a new interdisciplinary approach to organ building. This would have a profound impact on the treatment of many diseases. The ODET (Organ Design and Engineering postdoctoral Training) Program continues to provide scientifically rigorous, multidisciplinary research training for postdoctoral fellows. Individuals accepted into the Program have experience focused in an engineering or biological discipline and are cross-trained in an area of expertise complementary to their primary research background. Working at the intersection of engineering and molecular/developmental/regenerative biology, trainees learn a new language and ultimately develop a common dialect that effectively bridges disciplines. This new generation of scholars is prepared to address the complexity of organ design and engineering from an interdisciplinary approach. The program is enriched with outstanding dual-mentor interactions, regularly scheduled program meetings, where fellows and faculty cross-fertilize, and required coursework focused on biological science if fellows are engineers and engineering if their prior focus was in biology. Since its inception in 2007, the program has formalized the evaluation of trainees' development as well as provided increased opportunities for research presentations and feedback. We successfully changed the standard postdoctoral mode of training from the "one postdoctoral fellow - one mentor - one laboratory" approach to a true “dual-mentor” model where fellows spend time in the laboratories of two mentors and benefit from active communication across laboratories, institutions and geographic boundaries. This program continues to provide trainees with tools necessary to become independent investigators facile with an interdisciplinary approach to science. Trainees who have received support from this grant over the past 10 years have high quality publications, have moved to academic faculty, international research labs and industry leadership positions. We look forward to continuing to train leaders in multidisciplinary research with exposure to clinical challenges facilitated by close interactions with clinicians, while critically assessing and improving the fellowship experience by optimizing research and mentoring opportunities for the next generation of engineer-investigators in regenerative medicine.

可供移植的器官数量因供体短缺而受到严重限制。 再生医学已经成为一个领域，它带来了设计和创造人工智能的潜力。 器官或器官的一部分更接近现实。为了发展功能组织，需要将概念应用于 组织工程和分子/发育生物学的创新方式。这就需要一种新型的 科学家谁已经在工程和工程的接口的概念和方法训练有素， 分子/发育生物学学科。成功地整合这些方法可以 极大地促进了一种新的跨学科方法的形成，以器官建设。这将 对许多疾病的治疗有着深远的影响。 该ODET（器官设计和工程博士后培训）计划继续提供 为博士后研究员提供科学严谨的多学科研究培训。接受的个人 进入该计划有经验的工程或生物学科的重点，并交叉培训 在一个专业领域的补充，他们的主要研究背景。在十字路口工作 工程和分子/发育/再生生物学，学员学习一种新的语言， 最终发展出一种通用的语言，有效地连接了不同的学科。这种新一代 学者们准备从跨学科的角度来解决器官设计和工程的复杂性。 approach.该计划是丰富的优秀双导师互动，定期安排 计划会议，研究员和教师交叉施肥，并要求课程集中在 生物科学，如果研究员是工程师和工程师，如果他们以前的重点是生物学。 自2007年成立以来，该计划已正式评估学员的发展， 并为研究报告和反馈提供了更多的机会。我们成功 改变了标准的博士后培养模式，从“一个博士后-一个导师-一个 一个真正的“双导师”模式，研究员花时间在两个实验室的“实验室”的方法， 导师，并受益于跨实验室、机构和地理区域的积极沟通 边界该计划继续为学员提供必要的工具，使他们能够独立 对跨学科的科学方法很熟悉的研究者。获得支助的受训人员 在过去的10年里，从这笔赠款中获得了高质量的出版物，已经转移到学术机构， 国际研究实验室和行业领导地位。我们期待着继续训练 多学科研究的领导者，通过密切的互动促进临床挑战 与临床医生，同时通过优化研究来批判性地评估和改善奖学金经验 为再生医学的下一代工程师研究者提供指导机会。

项目成果

Designing Hydrogels for On-Demand Therapy.

• DOI: 10.1021/acs.accounts.6b00536
• 发表时间: 2017-04-18
• 期刊: Accounts of chemical research
• 影响因子: 18.3
• 作者: Oliva N;Conde J;Wang K;Artzi N
• 通讯作者: Artzi N

ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways.

ATF-3 表达通过下调 ERK 和 AKT 途径抑制黑色素瘤生长。

• DOI: 10.1038/s41374-020-00516-y
• 发表时间: 2021-05
• 期刊: Laboratory investigation; a journal of technical methods and pathology
• 作者: Zu T;Wang D;Xu S;Lee CAA;Zhen E;Yoon CH;Abarzua P;Wang S;Frank NY;Wu X;Lian CG;Murphy GF
• 通讯作者: Murphy GF

Sex dependent impact of gestational stress on predisposition to eating disorders and metabolic disease.

• DOI: 10.1016/j.molmet.2018.08.005
• 发表时间: 2018-11
• 期刊: Molecular metabolism
• 影响因子: 8.1
• 作者: Schroeder M;Jakovcevski M;Polacheck T;Drori Y;Ben-Dor S;Röh S;Chen A
• 通讯作者: Chen A

We need to shift the focus of aging research to aging itself.

• DOI: 10.1073/pnas.2307449120
• 发表时间: 2023-09-12
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Poganik, Jesse R.;Gladyshev, Vadim N.
• 通讯作者: Gladyshev, Vadim N.

Murine macrophages or their secretome delivered in alginate dressings enhance impaired wound healing in diabetic mice.

• DOI: 10.1016/j.biomaterials.2022.121692
• 发表时间: 2022-09
• 期刊: Biomaterials
• 影响因子: 14