Organ Design and Engineering Training Program (ODET Program)

可供移植的器官数量受到捐赠者短缺的严重限制。 再生医学已经成为一个带来设计和创造人工智能的潜力的领域 器官，或器官的一部分，更接近现实。开发功能组织需要将概念应用于 以创新的方式开展组织工程和分子/发育生物学研究。这就需要一种新型的 在工程学和科学的交汇点上受过良好的概念和方法训练的科学家 分子/发育生物学学科。成功集成这些方法可以 极大地促进了器官建设一种新的跨学科方法的形成。这将会 对许多疾病的治疗都有深远的影响。 ODET(器官设计和工程学博士后培训)计划继续提供 为博士后研究员提供科学严谨的多学科研究培训。接受的个人 有工程或生物学科经验，并接受过交叉培训 在与其主要研究背景相辅相成的专业领域。在十字路口工作 工程学和分子/发育/再生生物学，学员学习一门新的语言和 最终开发一种共同的方言，有效地架起学科之间的桥梁。这一新一代 学者们准备从跨学科的角度解决器官设计和工程的复杂性 接近。该计划通过定期安排的出色的双导师互动来丰富 项目会议，研究员和教员在会上交叉授精，所需的课程重点是 生物科学，如果研究员是工程师，如果他们之前的重点是生物学，则是工程学。 自2007年启动以来，该计划已将对学员发展的评估正式确定为 并为研究、陈述和反馈提供了更多的机会。我们成功地 改变了标准的博士后培养模式，从一个博士后研究员-一个导师-一个 实验室“接近真正的”双导师“模式，研究员花时间在两个人的实验室里 从跨实验室、机构和地理位置的积极沟通中获得导师和收益 边界。该计划继续为受训人员提供独立所需的工具 研究人员善于用跨学科的方法研究科学。获得支持的受训人员 在过去的10年里，从这笔拨款中有了高质量的出版物，已经转移到了学术教职员工， 国际研究实验室和行业领先地位。我们期待着继续训练 在多学科研究中处于领先地位，通过密切互动促进临床挑战 与临床医生合作，同时通过优化研究来严格评估和改善团契体验 并为再生医学的下一代工程师和研究人员提供指导机会。

The number of available organs for transplantation is severely limited by a shortage of donors. Regenerative medicine has emerged as a field that brings the potential of designing and creating artificial organs, or parts of organs, closer to reality. To develop functional tissue requires applying concepts in tissue engineering and molecular/developmental biology in innovative ways. This requires a new type of scientist who has been well-trained in the concepts and methods at the interfaces of engineering and the molecular/developmental biology disciplines. Successfully integrating these approaches could dramatically catalyze the formation of a new interdisciplinary approach to organ building. This would have a profound impact on the treatment of many diseases. The ODET (Organ Design and Engineering postdoctoral Training) Program continues to provide scientifically rigorous, multidisciplinary research training for postdoctoral fellows. Individuals accepted into the Program have experience focused in an engineering or biological discipline and are cross-trained in an area of expertise complementary to their primary research background. Working at the intersection of engineering and molecular/developmental/regenerative biology, trainees learn a new language and ultimately develop a common dialect that effectively bridges disciplines. This new generation of scholars is prepared to address the complexity of organ design and engineering from an interdisciplinary approach. The program is enriched with outstanding dual-mentor interactions, regularly scheduled program meetings, where fellows and faculty cross-fertilize, and required coursework focused on biological science if fellows are engineers and engineering if their prior focus was in biology. Since its inception in 2007, the program has formalized the evaluation of trainees' development as well as provided increased opportunities for research presentations and feedback. We successfully changed the standard postdoctoral mode of training from the "one postdoctoral fellow - one mentor - one laboratory" approach to a true “dual-mentor” model where fellows spend time in the laboratories of two mentors and benefit from active communication across laboratories, institutions and geographic boundaries. This program continues to provide trainees with tools necessary to become independent investigators facile with an interdisciplinary approach to science. Trainees who have received support from this grant over the past 10 years have high quality publications, have moved to academic faculty, international research labs and industry leadership positions. We look forward to continuing to train leaders in multidisciplinary research with exposure to clinical challenges facilitated by close interactions with clinicians, while critically assessing and improving the fellowship experience by optimizing research and mentoring opportunities for the next generation of engineer-investigators in regenerative medicine.