Organ Design and Engineering Training Program (ODET Program)

器官设计与工程培训项目（ODET项目）

• 批准号: 10246782
• 负责人: JOSEPH VINCENT BONVENTRE
• 金额: $ 43.81万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10246782
• 关键词: Engineering; Organ; Training Programs; design

The number of available organs for transplantation is severely limited by a shortage of donors. Regenerative medicine has emerged as a field that brings the potential of designing and creating artificial organs, or parts of organs, closer to reality. To develop functional tissue requires applying concepts in tissue engineering and molecular/developmental biology in innovative ways. This requires a new type of scientist who has been well-trained in the concepts and methods at the interfaces of engineering and the molecular/developmental biology disciplines. Successfully integrating these approaches could dramatically catalyze the formation of a new interdisciplinary approach to organ building. This would have a profound impact on the treatment of many diseases. The ODET (Organ Design and Engineering postdoctoral Training) Program continues to provide scientifically rigorous, multidisciplinary research training for postdoctoral fellows. Individuals accepted into the Program have experience focused in an engineering or biological discipline and are cross-trained in an area of expertise complementary to their primary research background. Working at the intersection of engineering and molecular/developmental/regenerative biology, trainees learn a new language and ultimately develop a common dialect that effectively bridges disciplines. This new generation of scholars is prepared to address the complexity of organ design and engineering from an interdisciplinary approach. The program is enriched with outstanding dual-mentor interactions, regularly scheduled program meetings, where fellows and faculty cross-fertilize, and required coursework focused on biological science if fellows are engineers and engineering if their prior focus was in biology. Since its inception in 2007, the program has formalized the evaluation of trainees' development as well as provided increased opportunities for research presentations and feedback. We successfully changed the standard postdoctoral mode of training from the "one postdoctoral fellow - one mentor - one laboratory" approach to a true “dual-mentor” model where fellows spend time in the laboratories of two mentors and benefit from active communication across laboratories, institutions and geographic boundaries. This program continues to provide trainees with tools necessary to become independent investigators facile with an interdisciplinary approach to science. Trainees who have received support from this grant over the past 10 years have high quality publications, have moved to academic faculty, international research labs and industry leadership positions. We look forward to continuing to train leaders in multidisciplinary research with exposure to clinical challenges facilitated by close interactions with clinicians, while critically assessing and improving the fellowship experience by optimizing research and mentoring opportunities for the next generation of engineer-investigators in regenerative medicine.

由于供体短缺，可供移植的器官数量受到严重限制。 再生医学已经成为一个带来设计和创造人工潜力的领域 器官或器官的一部分，更接近现实。开发功能性组织需要应用以下概念 以创新方式进行组织工程和分子/发育生物学。这需要一种新型的 受过良好训练的科学家，其概念和方法涉及工程学和自然科学的交叉点 分子/发育生物学学科。成功整合这些方法可以 极大地促进了器官构建新的跨学科方法的形成。这会 对许多疾病的治疗产生深远的影响。 ODET（器官设计与工程博士后培训）计划继续提供 为博士后研究员提供科学严谨的多学科研究培训。接受个人 加入该计划的人具有工程或生物学科的经验，并接受过交叉培训 在与其主要研究背景互补的专业领域。在十字路口工作 工程和分子/发育/再生生物学的学员学习一门新的语言 最终开发出一种有效连接学科的共同方言。这新一代的 学者们准备从跨学科的角度解决器官设计和工程的复杂性 方法。该计划通过定期安排的出色的双导师互动而丰富 项目会议，研究员和教师相互交流，所需的课程作业重点关注 如果研究员是工程师，则为生物科学；如果他们之前的关注点是生物学，则为工程学。 自2007年启动以来，该计划已将学员的发展评估正式化为 并提供了更多的研究展示和反馈的机会。我们成功地 改变了博士后标准培养模式，由“一名博士后-一名导师-一名” 实验室”方法，以实现真正的“双导师”模型，其中研究员在两个实验室中度过时间 导师并从跨实验室、机构和地理区域的积极沟通中受益 边界。该计划继续为学员提供独立所需的工具 研究人员易于采用跨学科的科学方法。获得支持的学员 从这一补助金来看，过去10年有高质量的出版物，已转向学术教师， 国际研究实验室和行业领导地位。我们期待继续训练 多学科研究的领导者，通过密切的互动接触临床挑战 与临床医生一起，同时通过优化研究批判性地评估和改善研究体验 并为下一代再生医学工程师研究人员提供指导机会。