Organ Design and Engineering Training Program (ODET Program)

描述（由申请人提供）：由于供体短缺，可用器官的数量受到严重限制。一个新的科学领域，再生医学，已经出现，使设计和创造人造器官，或器官的一部分，更接近现实的潜力。功能组织的开发需要以新的方式应用发育生物学、定量科学和组织工程方法中的概念。这需要一种新型的科学家，他们在工程和其他学科的界面上接受过良好的概念和方法训练。成功地整合这些方法可以极大地促进器官构建新的跨学科方法的形成。这将对许多疾病的治疗产生深远的影响。 在ODET（器官设计和工程博士后培训）计划继续提供科学严谨，多学科的研究培训博士后研究员在哈佛和麻省理工学院。被接受进入该计划的个人在其主要研究领域之外的专业领域进行交叉培训。这是ARRA资助的培训计划的延续，规模有所缩小。在工程和发育/再生生物学的交叉点工作，学员学习一种新的语言，并最终开发出一种通用的方言，有效地桥梁学科。新一代的学者准备从跨学科的方法来解决器官设计和工程的复杂性。该计划丰富了优秀的双导师互动，定期计划指导和必修课程。 自2007年成立以来，该计划已正式评估受训人员的发展，并提供更多的机会进行研究介绍和反馈。我们成功地改变了标准的博士后培训模式，从“一个博士后研究员-一个导师-一个实验室”的方法到真正的“双导师”模式，研究员在两个导师的实验室里度过时间，并能够促进跨实验室，机构和地理边界的积极沟通。该计划继续为学员提供必要的工具，使其成为独立的调查人员，易于采用跨学科的科学方法。在过去5年中获得该补助金支持的受训人员拥有高质量的出版物，已进入学术教师，国际研究实验室和行业领导职位。我们期待着继续培养多学科研究的领导者，同时通过优化再生医学下一代工程师研究人员的研究和指导机会，批判性地评估和改善奖学金经验。

DESCRIPTION (provided by applicant): The number of available organs is severely limited by a shortage of donors. A new field of science, regenerative medicine, has emerged that brings the potential of designing and creating artificial organs, or parts of organs, closer to reality. T develop functional tissue requires applying concepts in developmental biology, quantitative science and tissue engineering approaches in a novel way. This requires a new type of scientist who has been well-trained in the concepts and methods at the interfaces of engineering and other disciplines. Successfully integrating these approaches could dramatically catalyze the formation of a new interdisciplinary approach to organ building. This would have a profound impact on the treatment of many diseases. The ODET (Organ Design and Engineering postdoctoral Training) Program continues to provide scientifically rigorous, multidisciplinary research training to postdoctoral fellows at Harvard and MIT. Individuals accepted into the Program are cross-trained in an area of expertise outside of their primary research field. This is a continuation of an ARRA-funded training program, reduced in size. Working at the intersection of engineering and developmental/regenerative biology, trainees learn a new language and ultimately develop a common dialect that effectively bridges disciplines. This new generation of scholars is prepared to address the complexity of organ design and engineering from an interdisciplinary approach. The program is enriched with outstanding dual-mentor interactions, regularly scheduled program mentoring and a required course. Since its inception in 2007, the program has formalized the evaluation of trainees' development as well as provided increased opportunities for research presentations and feedback. We successfully changed the standard postdoctoral mode of training from the "one postdoctoral fellow - one mentor - one laboratory" approach to a true ["dual-mentor" model where fellows spend time in the laboratories of two mentors and are able to facilitate active communication across laboratories, institutions and geographic boundaries.] This program continues to provide trainees with tools necessary to become independent investigators facile with an interdisciplinary approach to science. Trainees who have received support from this grant over the past 5 years have high quality publications, have moved to academic faculty, international research lab and industry leadership positions. We look forward to continuing to train leaders in multidisciplinary research with exposure to clinical challenges, while critically assessing and improving the fellowship experience by optimizing research and mentoring opportunities for the next generation of engineer-investigators in regenerative medicine.