Organ Design and Engineering Training Program (ODET Program)

描述（由申请人提供）：由于供体短缺，可用器官的数量受到严重限制。一个新的科学领域——再生医学——已经出现，它使设计和制造人造器官或器官部分的潜力更接近现实。开发功能性组织需要以一种新颖的方式应用发育生物学、定量科学和组织工程方法中的概念。这需要一种新型的科学家，他们在工程学和其他学科的概念和方法方面受过良好的训练。成功地整合这些方法可以极大地催化形成一种新的跨学科方法来构建器官。这将对许多疾病的治疗产生深远的影响。ODET（器官设计与工程博士后培训）计划继续为哈佛大学和麻省理工学院的博士后提供科学严谨的多学科研究培训。接受该计划的个人在其主要研究领域之外的专业领域进行交叉培训。这是arra资助的培训项目的延续，规模有所缩小。在工程和发展/再生生物学的交叉点工作，学员学习一种新的语言，并最终发展一种共同的方言，有效地连接学科。这新一代的学者准备从跨学科的方法来解决器官设计和工程的复杂性。该项目丰富了优秀的双导师互动，定期安排的项目指导和必修课程。自2007年启动以来，该项目对学员的发展进行了正式评估，并提供了更多的研究报告和反馈机会。我们成功地改变了标准的博士后培养模式，从“一个博士后-一个导师-一个实验室”的方式转变为真正的“双导师”模式，即研究员在两位导师的实验室中度过时间，并能够促进跨实验室、机构和地理边界的积极沟通。这个项目继续为受训者提供必要的工具，使他们成为独立的研究者，并能方便地使用跨学科的科学方法。在过去的5年里，获得资助的学员都发表了高质量的论文，并在学术院系、国际研究实验室和行业领导岗位上工作。我们期待着继续培养具有临床挑战的多学科研究的领导者，同时通过优化研究和指导下一代再生医学工程师-研究人员的机会，批判性地评估和改善奖学金经验。

DESCRIPTION (provided by applicant): The number of available organs is severely limited by a shortage of donors. A new field of science, regenerative medicine, has emerged that brings the potential of designing and creating artificial organs, or parts of organs, closer to reality. T develop functional tissue requires applying concepts in developmental biology, quantitative science and tissue engineering approaches in a novel way. This requires a new type of scientist who has been well-trained in the concepts and methods at the interfaces of engineering and other disciplines. Successfully integrating these approaches could dramatically catalyze the formation of a new interdisciplinary approach to organ building. This would have a profound impact on the treatment of many diseases. The ODET (Organ Design and Engineering postdoctoral Training) Program continues to provide scientifically rigorous, multidisciplinary research training to postdoctoral fellows at Harvard and MIT. Individuals accepted into the Program are cross-trained in an area of expertise outside of their primary research field. This is a continuation of an ARRA-funded training program, reduced in size. Working at the intersection of engineering and developmental/regenerative biology, trainees learn a new language and ultimately develop a common dialect that effectively bridges disciplines. This new generation of scholars is prepared to address the complexity of organ design and engineering from an interdisciplinary approach. The program is enriched with outstanding dual-mentor interactions, regularly scheduled program mentoring and a required course. Since its inception in 2007, the program has formalized the evaluation of trainees' development as well as provided increased opportunities for research presentations and feedback. We successfully changed the standard postdoctoral mode of training from the "one postdoctoral fellow - one mentor - one laboratory" approach to a true ["dual-mentor" model where fellows spend time in the laboratories of two mentors and are able to facilitate active communication across laboratories, institutions and geographic boundaries.] This program continues to provide trainees with tools necessary to become independent investigators facile with an interdisciplinary approach to science. Trainees who have received support from this grant over the past 5 years have high quality publications, have moved to academic faculty, international research lab and industry leadership positions. We look forward to continuing to train leaders in multidisciplinary research with exposure to clinical challenges, while critically assessing and improving the fellowship experience by optimizing research and mentoring opportunities for the next generation of engineer-investigators in regenerative medicine.