权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Visual cortical mechanisms for the perception of self-generated vs. external motion

感知自生运动与外部运动的视觉皮层机制

基本信息

批准号：
10703373
负责人：
Stephen Louis Macknik
金额：
$ 49.93万
依托单位：
SUNY DOWNSTATE MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10703373
关键词：
Address Affect Amblyopia Attention Automobile Driving Behavior Behavioral Brain Computer Models Data Detection Discrimination Disease Dissociation Drops Electrodes Equilibrium Eye Eye Movements Feedback Future Human Image Judgment Knowledge Lead Link Measurement Measures Methods Modeling Monkeys Motion Motion Perception National Eye Institute Neurons Ocular Fixation Ocular Physiology Outcome Pathway interactions Perception Performance Persons Phase Physiological Population Primates Process Production Proprioception Psychometrics Psychophysics Publishing Research Research Priority Retina Role Saccades Self Perception Signal Transduction Source Space Perception Stimulus Strabismus System Techniques Texture Therapeutic Time V1 neuron Variant Vertigo Vision Visual Visual Cortex Visual Perception Work area striata awake biophysical model detection sensitivity equilibration disorder experimental study extrastriate information processing loss of function nervous system disorder neural neuroadaptation neuromechanism neurophysiology neurotransmission nonhuman primate novel novel strategies object motion oculomotor programs response retinal imaging statistics visual processing

项目摘要

How do we distinguish motion in the world from similar retinal image displacements due to eye movements? This problem has special importance in diseases such as vertigo and a variety of spatial orientation disorders, where deficits in motion perception—including the suppression of self-motion—lead to devastating conse- quences. Impaired balance and motion perception substantially impact people’s daily lives, hindering spatial judgments and impeding performance during bodily motion tasks, such as ambulating or driving a vehicle. Until we know how the brain differentiates self-motion from external motion, we will be unable to develop therapeutic advances to address such disorders. Pioneering research in the 1960's - 90's—indeed the first published awake non-human primate (NHP) vision study—asked whether early cortical neurons discerned ocular from external motion, with the majority concluding that primary visual cortex (V1) neurons responded similarly to either type of motion. These studies used different tasks for self-generated vs external motion conditions, however, meaning that the respective neural responses evoked by either motion were not directly comparable. Thus, no research to date has developed a model for how neurons in V1 respond to external vs. self-generated motion. Recent work from the MPIs' labs, and others, has begun to use novel methods to directly compare self- vs real-motion responses in V1. We propose a transformative study to leverage these new techniques to evaluate the responses of V1 neurons to saccadic eye movements of all sizes under equivalent stimuli motions, with directly comparable viewing tasks in all conditions, in all layers of V1 simultaneously, and to develop a model that links the specific contributions of V1 circuits to perception. Our preliminary data suggests that V1 neurons can differentiate be- tween self-generated and external motion, driving our hypotheses: 1) V1 neurons distinguish between self- generated ocular motion vs. external retinal image motion, 2) an inhibitory feedback signal occurs during re- sponses to self-generated motion to drive the discrimination process, and 3) V1 responses to eye movements interact with responses driven by external motion in a nonlinear—though predictable—fashion, leading to both physiological and perceptual effects on the detection of retinal motion. By comparing neurophysiological re- sponses directly to perception in behaving NHPs, we will determine the contribution of V1 neurons to discerning external vs self-generated motion, as well as the provenance of any feedback (and/or perhaps feedforward) signals, using laminar analysis. These studies will establish the contributions of signals arriving to (or arising within) different V1 layers, so as to dissociate external vs self- motion. We will create quantitative models (based on our previously established models) using the new ground truth measurements from the proposed research, to determine the precise neural and perceptual consequences of each V1 circuit involved. The studies will elu- cidate loss of function in various oculomotor and neurological disorders and as such is directly relevant to the research priorities of the Strabismus, Amblyopia, and Visual Processing program at the National Eye Institute.

我们如何区分世界上的运动和由眼球运动引起的视网膜图像位移？

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Gaze mechanisms enabling the detection of faint stars in the night sky.

DOI：
10.1111/ejn.15335
发表时间：
2021-08
期刊：
The European journal of neuroscience
影响因子：
0
作者：
Alexander RG;Mintz RJ;Custodio PJ;Macknik SL;Vaziri A;Venkatakrishnan A;Gindina S;Martinez-Conde S
通讯作者：
Martinez-Conde S

Visual Illusions in Radiology: Untrue Perceptions in Medical Images and Their Implications for Diagnostic Accuracy.

DOI：
10.3389/fnins.2021.629469
发表时间：
2021
期刊：
Frontiers in neuroscience
影响因子：
4.3
作者：
Alexander RG;Yazdanie F;Waite S;Chaudhry ZA;Kolla S;Macknik SL;Martinez-Conde S
通讯作者：
Martinez-Conde S

Perceptual hue, lightness, and chroma are represented in a multidimensional functional anatomical map in macaque V1.

猕猴 V1 的感知色调、亮度和色度以多维功能解剖图表示

DOI：
10.1016/j.pneurobio.2022.102251
发表时间：
2022-05
期刊：
PROGRESS IN NEUROBIOLOGY
影响因子：
6.7
作者：
Li, Ming;Ju, Niansheng;Jiang, Rundong;Liu, Fang;Jiang, Hongfei;Macknik, Stephen;Martinez-Conde, Susana;Tang, Shiming
通讯作者：
Tang, Shiming

Microsaccades mediate perceptual alternations in Monet's "Impression, sunrise".