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1/1 NADIA U24 Administrative Core

1/1 NADIA U24 行政核心

基本信息

批准号：
10683279
负责人：
FULTON T CREWS
金额：
$ 48.69万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10683279
关键词：
Address Adolescence Adolescent Adult Affect Alcohol consumption Alcohols Animal Model Astrocytes Behavior Behavioral Brain Brain Pathology Chemistry Choline O-Acetyltransferase Clinical Research Clustered Regularly Interspaced Short Palindromic Repeats Cognition Cognitive Collaborations Communication Communities Complement Complex Data Decision Making Development Ensure Epigenetic Process Ethanol Evaluation Experimental Designs Extinction Faculty Funding Gene Expression Regulation General Population Genes Goals Health Policy Heavy Drinking Human Impulsivity Individual Joints Leadership Link Measures Microglia Molecular Motivation National Institute on Alcohol Abuse and Alcoholism Neurobiology Neuroimmune Neurons Neurotransmitters Organization administrative structures Pathology Pathway interactions Physiological Physiology Prevention Procedures Productivity Progress Reports Psychopathology Public Health Publications Recommendation Regulator Genes Research Research Design Research Personnel Research Support Review Literature Risk Behaviors Role Sleep disturbances Structure Therapeutic Intervention Translations United States National Institutes of Health Writing adolescent alcohol exposure adolescent binge drinking adolescent health alcohol consequences alcohol effect alcohol exposure alcohol research alcohol sensitivity anxiety-like behavior behavioral outcome data integration drinking epigenetic regulation flexibility indexing meetings neural neurochemistry neurodevelopment neuroinflammation neurotransmission new technology novel pharmacologic prevent psychologic repository sex symposium synergism therapeutic development tool translational goal translational potential translational study underage drinking

项目摘要

ABSTRACT 1/1 U24 NADIA ADMINISTRATIVE CORE - SUMMARY This is the second renewal of the Neurobiology of Adolescent Drinking in Adulthood (NADIA) Administrative Core (NADIA Administrative Core-U24, RFA-AA-20-004). The Administrative Core provides organizational and scientific leadership to achieve the goal of our Consortium: to elucidate persistent changes in complex brain function-behavior relationships following adolescent alcohol exposure. Adolescent binge and extreme drinking are common, and while many factors contribute to human brain development and alcohol use during adoles- cence, animal models are critical for understanding the specific consequences of alcohol exposure on the brain and behavior during this crucial developmental period. In the previous funding periods, the NADIA discovered that adolescent intermittent ethanol (AIE) led to multiple behavioral, neurochemical and physiological patholo-gies in adulthood. Mechanistic studies revealed that these AIE-induced changes could be prevented or re-versed by targeting specific neurotransmission, neuroinflammation, or epigenetic regulation of genes. The Consortium has been very productive, as evidenced by our recent literature reviews and over 200 publications. To promote and facilitate continued progress, the NADIA Administrative Core is the main organizational unit of the Consortium and serves as the liaison between the Scientific Core, the eight Research Components, the NADIA Steering Committee, the External Advisory Board, and the NIAAA. The Administrative Core organizes all Consortium activities including retreats, progress reports and External Advisory Board evaluations of cores and components. The Administrative Core ensures consistent and forward progress by facilitating communica-tion and promoting integration of data among the components and cores. The Core develops scientific and conceptual themes as well as recommended operating procedures that cross components. The Core provides a repository for all publications generated by the Consortium. Finally, the Core facilitates dissemination and translation of NADIA-generated data, in part by targeted interactions with the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) and other alcohol research groups. This NADIA renewal exactly fulfills the molecular mechanism and translation goals of this RFA leading to development of therapeu-tic interventions of adult psychopathologies of adolescent alcohol consumption. Understanding the impact of underage drinking on adult neurobiology is important to guide public health initiatives, and the NADIA Adminis-trative Core creates synergies for such discoveries across the Consortium.

抽象的 1/1 U24 NADIA 行政核心 - 摘要这是成年期青少年饮酒神经生物学 (NADIA) 管理的第二次更新核心（NADIA 管理核心-U24、RFA-AA-20-004）。行政核心提供组织和科学领导力以实现我们联盟的目标：阐明复杂大脑的持续变化青少年酒精暴露后的功能-行为关系。青少年酗酒和酗酒很常见，虽然许多因素会影响人类大脑的发育和青少年时期的饮酒—— 因此，动物模型对于了解酒精暴露对人体的具体影响至关重要。在此关键发育时期的大脑和行为。在之前的资助期间，NADIA 发现青少年间歇性乙醇（AIE）会导致多种行为、神经化学和成年期的生理病理学。机制研究表明，这些 AIE 引起的变化可能通过针对特定的神经传递、神经炎症或表观遗传调节来预防或逆转基因。正如我们最近的文献综述和其他方面所证明的那样，该联盟非常富有成效 200 种出版物。为了促进和促进持续进步，NADIA 行政核心是主要的该联盟的组织单位，作为科学核心、八个研究中心之间的联络人组成部分：NADIA 指导委员会、外部顾问委员会和 NIAAA。行政部门核心组织所有联盟活动，包括务虚会、进度报告和外部顾问委员会核心和组件的评估。行政核心通过以下方式确保持续和向前的进展促进组件和核心之间的通信并促进数据集成。核心制定科学和概念主题以及跨领域的推荐操作程序成分。核心为联盟生成的所有出版物提供了一个存储库。最后，核心促进 NADIA 生成的数据的传播和翻译，部分是通过与国家酒精与青春期神经发育联盟 (NCANDA) 和其他酒精研究组。此次 NADIA 更新完全实现了 RFA 领先的分子机制和翻译目标开发针对青少年饮酒的成人精神病理学的治疗干预措施。了解未成年人饮酒对成人神经生物学的影响对于指导公共卫生非常重要 NADIA 管理核心为整个联盟的此类发现创造了协同效应。