UNC Center for AIDS Research Core E Clinical Pharmacology/Analytical Chemistry

北卡罗来纳大学艾滋病研究中心核心 E 临床药理学/分析化学

• 批准号: 10840664
• 负责人: Angela D Kashuba
• 金额: $ 30.77万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10840664
• 关键词: UNC; Center; AIDS; Research; Core

PROJECT SUMMARY/ABSTRACT – CLINICAL PHARMACOLOGY AND ANALYTICAL CHEMISTRY (CPAC) CORE (CORE E) The overarching goal of the Clinical Pharmacology and Analytical Chemistry (CPAC) Core is to facilitate the development of safe, effective strategies for HIV prevention, treatment and cure. To achieve this goal, the CPAC Core provides pharmacology and bioanalytical expertise to advance research within and beyond the UNC CFAR through the following specific aims: (1) provide services to expedite translation of HIV research into therapeutic strategies, (2) introduce new services to respond to evolving HIV research needs, (3) interact within and beyond the UNC CFAR to enhance HIV research collaborations, (4) support scientific working groups, research interest groups, early stage investigators, and investigators new to HIV to develop the next generation of scientific leadership, (5) prioritize dissemination/outreach, strategic planning, and evaluation to maximize impact, and (6) follow standardized policies and procedures to promote harmonious intra-CFAR interaction. The CPAC Core executes these aims by proactively engaging investigators to identify and deliver services essential for HIV pharmacology research. The Core contributes to the design, management, analysis, and publication of HIV research by assisting with hypothesis framing, study design, and grant/proposal development, by facilitating multidisciplinary and translational approaches to clinical study design and conduct, and by selecting or generating optimal bioanalytical or pharmacometric methods, with subsequent provision of analyses, in both preclinical and clinical settings. New services are developed to respond to the evolving needs of the HIV research community working within priority research areas as well as tailored to individual investigator requests. Early stage investigators and investigators new to HIV research receive the highest priority for Core services. Strong institutional support from the UNC Eshelman School of Pharmacy allows the Core to take full advantage of existing infrastructure and resources, including contacts with faculty renowned for their expertise in specialized fields of pharmacology. The Core Co-Directors, Drs. Angela Kashuba and Mackenzie Cottrell, are responsible for Core management and strategic planning, in consultation with the Core’s Internal and External Advisory Boards, as well as through surveys of the CFAR membership and discussions at CFAR retreats.

项目总结/摘要-临床药理学和分析 化学品（CPAC）核心（核心E） 临床药理学和分析化学（CPAC）核心的总体目标是促进 制定安全、有效的艾滋病毒预防、治疗和治愈战略。为了实现这一目标，CPAC 核心提供药理学和生物分析专业知识，以推动研究内外的CSPCFAR 通过以下具体目标：（1）提供服务，加快艾滋病毒研究转化为治疗 战略，（2）引入新的服务，以应对不断变化的艾滋病毒研究需求，（3）内外互动 加强艾滋病毒研究合作，（4）支持科学工作组，研究兴趣 小组，早期研究人员和新的艾滋病毒研究人员开发下一代科学 领导，（5）优先考虑传播/外联、战略规划和评估，以最大限度地发挥影响，以及（6） 遵循标准化的政策和程序，促进CFAR内部和谐的互动。CPAC核心 通过积极主动地让调查人员参与确定和提供艾滋病毒所必需的服务来实现这些目标 药理学研究该核心有助于艾滋病毒的设计、管理、分析和出版。 研究通过协助假设框架，研究设计和赠款/提案开发，通过促进 临床研究设计和实施的多学科和转化方法，并通过选择或 产生最佳的生物分析或药物计量学方法，随后提供分析， 临床前和临床环境。开发新的服务以满足艾滋病毒研究不断变化的需求 在优先研究领域内工作的社区，以及针对个人研究者的要求。早期 阶段调查人员和艾滋病毒研究的新调查人员获得核心服务的最高优先权。强 从药学的Eshelman学校的机构支持允许核心充分利用 现有的基础设施和资源，包括与以其专业知识而闻名的教师的联系 药理学领域。核心联席董事Angela Kashuba博士和麦肯齐科特雷尔博士负责 为核心管理和战略规划，与核心的内部和外部咨询 委员会，以及通过对CFAR成员的调查和CFAR务虚会的讨论。