FEAR LEARNING IN MICE AND DISORDERS OF FEAR IN HUMANS

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to examine the molecular mechanisms of fear learning and extinction in genetic mouse models, to examine the genetics of PTSD, particularly focusing on the NMDA receptor genes in humans, and to perform a clinical trial for treatment of PTSD in traumatized women using D-cycloserine to enhance the NMDA-dependent learning underlying behavior-based exposure therapy. During the reporting period, we've begun to further examine NMDA function in mouse through the use of a 'floxed' inducible deletion NMDA receptor subunit 1 mouse line.