FEAR LEARNING IN MICE AND DISORDERS OF FEAR IN HUMANS
小鼠的恐惧学习和人类的恐惧障碍
基本信息
- 批准号:7562647
- 负责人:
- 金额:$ 3.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-05-01 至 2008-04-30
- 项目状态:已结题
- 来源:
- 关键词:BehaviorClinical TreatmentClinical TrialsComputer Retrieval of Information on Scientific Projects DatabaseCycloserineDiseaseFrightFundingGeneticGoalsGrantHumanInstitutionLearningMolecularMusN-Methyl-D-Aspartate ReceptorsN-MethylaspartatePost-Traumatic Stress DisordersReceptor GeneReportingResearchResearch PersonnelResourcesSourceUnited States National Institutes of HealthWomanbaselearning extinctionmouse model
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The goal of this project is to examine the molecular mechanisms of fear learning and extinction in genetic mouse models, to examine the genetics of PTSD, particularly focusing on the NMDA receptor genes in humans, and to perform a clinical trial for treatment of PTSD in traumatized women using D-cycloserine to enhance the NMDA-dependent learning underlying behavior-based exposure therapy.
During the reporting period, we've begun to further examine NMDA function in mouse through the use of a 'floxed' inducible deletion NMDA receptor subunit 1 mouse line.
这个子项目是许多研究子项目中利用
资源由NIH/NCRR资助的中心拨款提供。子项目和
调查员(PI)可能从NIH的另一个来源获得了主要资金,
并因此可以在其他清晰的条目中表示。列出的机构是
该中心不一定是调查人员的机构。
该项目的目标是研究小鼠遗传模型中恐惧学习和消退的分子机制,研究创伤后应激障碍的遗传学,特别是人类的NMDA受体基因,并进行一项临床试验,使用D-环丝氨酸治疗创伤后妇女的创伤后应激障碍,以加强基于行为的暴露疗法背后的NMDA依赖学习。
在报告期间,我们已经开始通过使用一种可诱导的NMDA受体亚单位1小鼠株系来进一步研究NMDA在小鼠中的功能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kerry J Ressler其他文献
The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic Stress Disorder Enters the Age of Large-Scale Genomic Collaboration
精神病基因组学联盟创伤后应激障碍工作组:创伤后应激障碍进入大规模基因组协作时代
- DOI:
10.1038/npp.2015.118 - 发表时间:
2015-04-23 - 期刊:
- 影响因子:7.100
- 作者:
Mark W Logue;Ananda B Amstadter;Dewleen G Baker;Laramie Duncan;Karestan C Koenen;Israel Liberzon;Mark W Miller;Rajendra A Morey;Caroline M Nievergelt;Kerry J Ressler;Alicia K Smith;Jordan W Smoller;Murray B Stein;Jennifer A Sumner;Monica Uddin - 通讯作者:
Monica Uddin
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic
针对情绪和焦虑障碍中的异常神经回路:从实验室到临床
- DOI:
10.1038/nn1944 - 发表时间:
2007-08-28 - 期刊:
- 影响因子:20.000
- 作者:
Kerry J Ressler;Helen S Mayberg - 通讯作者:
Helen S Mayberg
Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
基于恐惧和焦虑的障碍中的炎症:创伤后应激障碍、广泛性焦虑障碍及其他
- DOI:
10.1038/npp.2016.146 - 发表时间:
2016-08-11 - 期刊:
- 影响因子:7.100
- 作者:
Vasiliki Michopoulos;Abigail Powers;Charles F Gillespie;Kerry J Ressler;Tanja Jovanovic - 通讯作者:
Tanja Jovanovic
Models of Intergenerational and Transgenerational Transmission of Risk for Psychopathology in Mice
小鼠心理病理学风险的代际和跨代传递模型
- DOI:
10.1038/npp.2015.249 - 发表时间:
2015-08-18 - 期刊:
- 影响因子:7.100
- 作者:
Torsten Klengel;Brian G Dias;Kerry J Ressler - 通讯作者:
Kerry J Ressler
PACAP and the PAC1 Receptor in Post-Traumatic Stress Disorder
创伤后应激障碍中的促肾上腺皮质激素释放肽(PACAP)及其 PAC1 受体
- DOI:
10.1038/npp.2012.147 - 发表时间:
2012-11-13 - 期刊:
- 影响因子:7.100
- 作者:
Brian G Dias;Kerry J Ressler - 通讯作者:
Kerry J Ressler
Kerry J Ressler的其他文献
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{{ truncateString('Kerry J Ressler', 18)}}的其他基金
THE ROLE OF NEUREGULIN AND ITS RECEPTOR, ERBB4, IN CONDITIONED FEAR LEARNING
神经调节蛋白及其受体 ERBB4 在条件恐惧学习中的作用
- 批准号:
7562620 - 财政年份:2007
- 资助金额:
$ 3.16万 - 项目类别:
AMYGDALA VS HIPPOCAMPAL BDNF FUNCTION WITH MOLECULAR GENETIC TECHNIQUES
杏仁核与海马 BDNF 功能与分子遗传技术
- 批准号:
7562621 - 财政年份:2007
- 资助金额:
$ 3.16万 - 项目类别:
GENETIC AND TRAUMA-RELATED RISK FACTORS FOR PTSD
创伤后应激障碍的遗传和创伤相关风险因素
- 批准号:
7562648 - 财政年份:2007
- 资助金额:
$ 3.16万 - 项目类别:
MOLECULAR REGULATION OF GABAA RECEPTORS IN THE AMYGDALA
杏仁核中 GABAA 受体的分子调控
- 批准号:
7562649 - 财政年份:2007
- 资助金额:
$ 3.16万 - 项目类别:
EXAMINATION OF ALLOSTERIC SITE OF SEROTONIN TRANSPORTER USING TRANSGENIC MICE
使用转基因小鼠检查血清素转运蛋白的变构位点
- 批准号:
7562646 - 财政年份:2007
- 资助金额:
$ 3.16万 - 项目类别:
ROLE OF BDNF AND TRKB IN CONDITIONED DEFEAT
BDNF 和 TRKB 在条件性失败中的作用
- 批准号:
7349232 - 财政年份:2006
- 资助金额:
$ 3.16万 - 项目类别:
Molecular Regulation of GABAalpha Function in Amygdala
杏仁核 GABAα 功能的分子调控
- 批准号:
7276612 - 财政年份:2006
- 资助金额:
$ 3.16万 - 项目类别:
Molecular Regulation of GABA(A) Receptor Function in Amygdala
杏仁核 GABA(A) 受体功能的分子调控
- 批准号:
7141576 - 财政年份:2006
- 资助金额:
$ 3.16万 - 项目类别:
GENETICS AND TRAUMA RELATED RISK FACTORS FOR PTSD
创伤后应激障碍 (PTSD) 的遗传和创伤相关风险因素
- 批准号:
7603625 - 财政年份:2006
- 资助金额:
$ 3.16万 - 项目类别:
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