GENETIC AND TRAUMA-RELATED RISK FACTORS FOR PTSD

创伤后应激障碍的遗传和创伤相关风险因素

• 批准号: 7562648
• 负责人: Kerry J Ressler
• 金额: $ 2.37万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562648
• 关键词: Adult; Affective; Alleles; Brain-Derived Neurotrophic Factor; Child Abuse; Computer Retrieval of Information on Scientific Projects Database; Environment; Frequencies; Funding; Genes; Genetic; Goals; Grant; Haplotypes; Hospitals; Institution; Mediating; Mediator of activation protein; Mental Depression; Phenotype; Population; Post-Traumatic Stress Disorders; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Salivary; Sampling; Source; Symptoms; Trauma; United States National Institutes of Health; early childhood; inner city; psychologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are to first develop an infrastructure for doing large scale genetic and psychological studies of trauma-related and affective psychiatric illness in the general non-psychiatric population at Grady Hospital, serving the inner-city in Atlanta. The primary aims are to examine the 5HTTLPR and BDNF (Val66Met) alleles as mediators of trauma in the risk for PTSD as well as to examine the frequencies of other psychiatrically related haplotypes in this population. During the reporting period we have obtained samples from over 600 subjects including salivary dna and detailed phenotype information related to abuse, trauma, depression, and ptsd symptoms. The principal findings detail gene x environment interactions mediating the effects of early childhood abuse on adult depression and of early childhood abuse on PTSD in traumatized adults.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的目标是首先开发一种基础设施，用于在Grady医院的一般非精神病学人群中对创伤相关和情感精神病进行大规模遗传和心理学研究，为亚特兰大市中心服务。 主要目的是检查5HTTLPR和BDNF（Val66met）等位基因作为创伤的介体，以患有PTSD的风险，并检查该人群中其他精神科相关的单倍型的频率。 在报告期内，我们从600多名受试者中获得了与滥用，创伤，抑郁症和PTSD症状有关的详细表型信息的样本。 主要发现详细信息基因x环境相互作用，介导了儿童早期虐待对成年人抑郁症和幼儿虐待对创伤成年人的PTSD的影响。