GENETIC AND TRAUMA-RELATED RISK FACTORS FOR PTSD

创伤后应激障碍的遗传和创伤相关风险因素

• 批准号: 7562648
• 负责人: Kerry J Ressler
• 金额: $ 2.37万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562648
• 关键词: Adult; Affective; Alleles; Brain-Derived Neurotrophic Factor; Child Abuse; Computer Retrieval of Information on Scientific Projects Database; Environment; Frequencies; Funding; Genes; Genetic; Goals; Grant; Haplotypes; Hospitals; Institution; Mediating; Mediator of activation protein; Mental Depression; Phenotype; Population; Post-Traumatic Stress Disorders; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; Salivary; Sampling; Source; Symptoms; Trauma; United States National Institutes of Health; early childhood; inner city; psychologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this project are to first develop an infrastructure for doing large scale genetic and psychological studies of trauma-related and affective psychiatric illness in the general non-psychiatric population at Grady Hospital, serving the inner-city in Atlanta. The primary aims are to examine the 5HTTLPR and BDNF (Val66Met) alleles as mediators of trauma in the risk for PTSD as well as to examine the frequencies of other psychiatrically related haplotypes in this population. During the reporting period we have obtained samples from over 600 subjects including salivary dna and detailed phenotype information related to abuse, trauma, depression, and ptsd symptoms. The principal findings detail gene x environment interactions mediating the effects of early childhood abuse on adult depression and of early childhood abuse on PTSD in traumatized adults.

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目的目标是首先开发一个基础设施，用于在亚特兰大市中心的格雷迪医院对一般非精神病人群进行大规模的创伤相关和情感性精神疾病的遗传和心理研究。 主要目的是检查5 HTTLPR和BDNF（Val 66 Met）等位基因作为创伤介质的PTSD风险，以及检查该人群中其他精神病学相关单倍型的频率。 在报告期内，我们从600多名受试者那里获得了样本，包括唾液dna以及与虐待、创伤、抑郁和创伤后应激障碍症状相关的详细表型信息。 主要研究结果详细介绍了基因x环境的相互作用介导的影响，早期儿童虐待成人抑郁症和早期儿童虐待创伤后应激障碍的成年人。