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MOLECULAR REGULATION OF GABAA RECEPTORS IN THE AMYGDALA

MOLECULAR REGULATION OF GABAA RECEPTORS IN THE AMYGDALA
杏仁核中 GABAA 受体的分子调控
批准号:
7562649
负责人:
Kerry J Ressler
金额:
$2.37万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-05-01 至 2008-04-30

项目摘要

项目成果

Kerry J Ressler的其他基金

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to examine the hypothesis that activity-dependent downregulation of the GABAA receptor complex is a common mechanism shared by fear conditioning and benzodiazepine use, and that this shared mechanism may mediate stress-dependent relapse of addiction. This proposal utilizes molecular genetic approaches to examining the pre- and post-synaptic regulation of amygdala GABAA receptors following fear conditioning and acute, chronic and withdrawal phases of benzodiazepine use. During the reporting period we have completed analyses of GABA-A mRNA expression at baseline, following conditioned fear learning and following extinction of conditioned fear. We have also found significant effects on behavior when the GABA-alpha1 subunit is deleted from hippocampus and amygdala.
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    7562620
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  • 财政年份:
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  • 财政年份:
    2007
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  • 项目类别:
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  • 财政年份:
    2007
  • 负责人:
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