SYNAPTIC PLASTICITY AND EXTINCTION OF FEAR

突触可塑性和恐惧的消除

• 批准号: 7562667
• 负责人: Kerry J Ressler
• 金额: $ 2.37万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562667
• 关键词: Amygdaloid structure; Behavioral; Behavioral Genetics; Computer Retrieval of Information on Scientific Projects Database; Extinction (Psychology); Fright; Funding; Grant; Institution; Memory; Molecular; Mus; Recombinants; Research; Research Personnel; Resources; Role; Source; Synaptic plasticity; Technology; Training; United States National Institutes of Health; Work; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project allowed us to combine the work of mouse behavioral genetics, recombinant lentiviral technology and mouse behavioral studies for further work in the molecular mechanisms of amygdala functioning, synaptic plasticity, and the extinction of fear memories. We have completed the training aims of this project which were to optimize the molecular tools available to understand the role of the amygdala in the acquisition and extinction of fear.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目使我们能够将小鼠行为遗传学、重组慢病毒技术和小鼠行为研究结合起来，进一步研究杏仁核功能、突触可塑性和恐惧记忆消失的分子机制。 我们已经完成了这个项目的培训目标，即优化可用的分子工具，以了解杏仁核在获得和消除恐惧中的作用。