ROLE OF BDNF AND TRKB IN CONDITIONED DEFEAT

BDNF 和 TRKB 在条件性失败中的作用

• 批准号: 7349232
• 负责人: Kerry J Ressler
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-09 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349232
• 关键词: amygdala; conditioning; genes; hamsters; literature survey; publications; receptor; role

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study used viral vector-mediated gene transfer to over-express a truncated form of the TrkB receptor, which served as a dominant negative receptor for BDNF, in the amygdala of hamsters to expose to social defeat. We hypothesized that a blockade of BDNF signaling will block the acquisition, but not the expression, of conditioned defeat, a behavioral change observed following social defeat in hamsters. Early results are promising, and this grant has also funded the publication of a review manuscript on the BDNF ? TrkB interaction in amygdala.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。这项研究使用病毒载体介导的基因转移来过表达TRKB受体的截断形式，该形式是仓鼠的杏仁核中BDNF的主要负面受体，以暴露于社交失败中。我们假设BDNF信号的封锁将阻止收购，但不能阻止有条件失败的收购，而不是表达，这是仓鼠社交失败后观察到的行为变化。早期结果是有希望的，这笔赠款还资助了关于BDNF的审查手稿的出版？杏仁核中的TRKB相互作用。