Molecular and functional charcterization of a novel population of Foxp3+ regulatory T cells

新型 Foxp3 调节性 T 细胞群的分子和功能表征

• 批准号: nhmrc : 1032861
• 负责人: Prof Axel Kallies
• 金额: $ 26.29万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-functional-charcterization-t-cells/110871
• 关键词: Molecular; functional; charcterization; novel; population

Regulatory T cells (Tregs) are essential for the prevention of autoimmunity and death. We have identified a new population of effector or ïactiveÍ Tregs, and identified some of the proteins that are required for these cells to function. We now aim to examine the development of these cells in detail, illuminate their precise function, their distribution and mode of action. This has potentially huge implications in treatment and diagnosis of autoimmunity, cancer or transplantation.

调节性T细胞（Tcells）对于预防自身免疫和死亡至关重要。我们已经确定了一个新的效应细胞或激活细胞群，并确定了这些细胞发挥功能所需的一些蛋白质。我们现在的目标是详细研究这些细胞的发育，阐明它们的确切功能，分布和作用方式。这对自身免疫、癌症或移植的治疗和诊断具有潜在的巨大影响。