Transcriptional and epigenetic regulation of terminal lymphocyte differentiation and alterations of the same that lead to leukemia.

在发达国家，传染病是仅次于心脏病和癌症的第三大杀手，在治疗和预防方面投入了巨大的财政努力。尽管如此，结果往往令人失望。这些不良结果的一个原因是缺乏关于如何产生有效免疫反应的知识。该项目旨在更好地了解控制保护性淋巴细胞产生的过程。它将提供可能使疫苗开发和感染治疗更有针对性的方法的信息。由于分化缺陷也可能是白血病的一个原因，它也可能导致癌症治疗的靶点。

In the developed world infection diseases are the number three killer behind heart disease and cancer, and huge financial effort is put into treatment and prevention. Despite this, results have often been disappointing. One cause of these poor outcomes is the lack of knowledge of how effective immune responses are generated. This project aims to better understand the processes that control the generation of protective lymphocytes. It will deliver information that may enable a more targeted approach to vaccine-development and treatments of infections. As defective differentiation can also be a cause of leukemia it may also lead to targets of cancer treatment.