The role of the transcription factor IRF4 in peripheral Cd8 T cell differentiation

转录因子IRF4在外周Cd8 T细胞分化中的作用

• 批准号: nhmrc : 1032850
• 负责人: Prof Axel Kallies
• 金额: $ 26.62万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-transcription-factor-cell-differentiation/110869
• 关键词: role; transcription; factor; IRF4; peripheral

T cells protect against viral infections and fight cancer cells. In order to fulfill these roles T cells have to undergo significant phenotypic and functional changes. Our preliminary data indicate a central role for the regulator protein IRF4 in this process, as T cells that lack this protein are unable to grow and acquire the cellular tools necessary to provide protection. We wish to characterize the role of IRF4 in T cells in detail and aim to identify the processes regulated by IRF4.

T细胞可以预防病毒感染和对抗癌细胞。为了发挥这些作用，T细胞必须经历显着的表型和功能变化。我们的初步数据表明，调节蛋白IRF4在这一过程中发挥了核心作用，因为缺乏这种蛋白的T细胞无法生长并获得提供保护所需的细胞工具。我们希望详细描述IRF4在T细胞中的作用，并旨在确定IRF4调控的过程。