The role of the transcription factor IRF4 in peripheral Cd8 T cell differentiation
The role of the transcription factor IRF4 in peripheral Cd8 T cell differentiation
批准号:
nhmrc : 1032850
负责人:
Prof Axel Kallies
金额:
$26.62万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31
中文摘要
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英文摘要
T cells protect against viral infections and fight cancer cells. In order to fulfill these roles T cells have to undergo significant phenotypic and functional changes. Our preliminary data indicate a central role for the regulator protein IRF4 in this process, as T cells that lack this protein are unable to grow and acquire the cellular tools necessary to provide protection. We wish to characterize the role of IRF4 in T cells in detail and aim to identify the processes regulated by IRF4.
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