Protective mechanisms of MAP kinase phosphatase 5 in adipose tissue fibrosis, hepatic steatosis and atherosclerosis
Protective mechanisms of MAP kinase phosphatase 5 in adipose tissue fibrosis, hepatic steatosis and atherosclerosis
批准号:
nhmrc : 1149062
负责人:
Prof Axel Kallies
金额:
$23.52万
依托单位国家:
澳大利亚
项目类别:
Targeted Calls
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31
中文摘要
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英文摘要
Obesity and associated complications such as diabetes, non-alcoholic fatty liver disease and atherosclerosis are a serious health burden. Recently, we found that MKP5, a molecule that restricts intracellular signaling, plays a central role in preventing these diseases. This collaborative project will elucidate how precisely MKP5 acts and explore how this molecule can be targeted for the development of novel therapeutic strategies in prevention and treatment of human metabolic diseases.
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Differentiation of effector and tissue regulatory T cells
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批准号:DP210102705
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项目类别:Discovery Projects
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资助金额:$36.58万
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财政年份:2021
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation
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批准号:nhmrc : 1139607
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依托单位:
Molecular pathways that control differentiation and function of tissue-resident memory T cells
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批准号:nhmrc : 1147409
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项目类别:Project Grants
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资助金额:$59.39万
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财政年份:2018
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation
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批准号:nhmrc : GNT1139607
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项目类别:Research Fellowships
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资助金额:$70.74万
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财政年份:2018
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负责人:Prof Axel Kallies
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依托单位:
Maintenance of regulatory T cells during inflammation and tumor development by IL-33
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批准号:nhmrc : 1106378
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项目类别:Project Grants
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资助金额:$46.41万
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财政年份:2016
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负责人:Prof Axel Kallies
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依托单位:
Maintenance of regulatory T cells during inflammation and tumor development by IL-33
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批准号:nhmrc : GNT1106378
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项目类别:Project Grants
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资助金额:$67.7万
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财政年份:2016
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依托单位:
Regulation of metabolic dysfunction and exhaustion of virus-specific T cells during chronic infection
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批准号:nhmrc : GNT1085151
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项目类别:Project Grants
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资助金额:$72.1万
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财政年份:2015
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负责人:Prof Axel Kallies
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依托单位:
Regulation of metabolic dysfunction and exhaustion of virus-specific T cells during chronic infection
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批准号:nhmrc : 1085151
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项目类别:Project Grants
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资助金额:$49.95万
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财政年份:2015
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负责人:Prof Axel Kallies
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依托单位:
The role of the transcription factor IRF4 in peripheral Cd8 T cell differentiation
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批准号:nhmrc : 1032850
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项目类别:Project Grants
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资助金额:$26.62万
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财政年份:2012
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负责人:Prof Axel Kallies
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依托单位:
Molecular and functional charcterization of a novel population of Foxp3+ regulatory T cells
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批准号:nhmrc : 1032861
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项目类别:Project Grants
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资助金额:$26.29万
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财政年份:2012
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional and epigenetic regulation of terminal lymphocyte differentiation and alterations of the same that lead to leukemia.
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批准号:FT0992164
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项目类别:ARC Future Fellowships
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资助金额:$42.43万
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财政年份:2010
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional Regulation of T cell Memory Programming
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批准号:nhmrc : 637345
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资助金额:$36.61万
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财政年份:2010
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional regulation of T lymphocyte and dendritic cell development
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批准号:nhmrc : 637344
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项目类别:NHMRC Project Grants
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资助金额:$40.35万
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财政年份:2010
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional Regulation of Terminal T cell Differentiation by Blimp-1
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批准号:nhmrc : 516755
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项目类别:NHMRC Project Grants
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资助金额:$27.43万
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财政年份:2008
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负责人:Prof Axel Kallies
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依托单位:
国内基金
海外基金
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