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Protective mechanisms of MAP kinase phosphatase 5 in adipose tissue fibrosis, hepatic steatosis and atherosclerosis

Protective mechanisms of MAP kinase phosphatase 5 in adipose tissue fibrosis, hepatic steatosis and atherosclerosis
MAP激酶磷酸酶5在脂肪组织纤维化、肝脂肪变性和动脉粥样硬化中的保护机制
批准号:
nhmrc : 1149062
负责人:
Prof Axel Kallies
金额:
$23.52万
依托单位国家:
澳大利亚
项目类别:
Targeted Calls
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31

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中文摘要
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英文摘要
Obesity and associated complications such as diabetes, non-alcoholic fatty liver disease and atherosclerosis are a serious health burden. Recently, we found that MKP5, a molecule that restricts intracellular signaling, plays a central role in preventing these diseases. This collaborative project will elucidate how precisely MKP5 acts and explore how this molecule can be targeted for the development of novel therapeutic strategies in prevention and treatment of human metabolic diseases.
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Differentiation of effector and tissue regulatory T cells
  • 批准号:
    DP210102705
  • 项目类别:
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  • 财政年份:
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  • 负责人:
    Prof Axel Kallies
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Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation
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  • 项目类别:
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    Prof Axel Kallies
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Molecular pathways that control differentiation and function of tissue-resident memory T cells
Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation
  • 批准号:
    nhmrc : GNT1139607
  • 项目类别:
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  • 财政年份:
    2018
  • 负责人:
    Prof Axel Kallies
  • 依托单位:
国内基金
海外基金
Exploring the Intrinsic Mechanisms of CEO Turnover and Market
  • 批准号:
    --
  • 项目类别:
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  • 批准年份:
    2024
  • 负责人:
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Exploring the Intrinsic Mechanisms of CEO Turnover and Market Reaction: An Explanation Based on Information Asymmetry
  • 批准号:
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  • 项目类别:
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  • 资助金额:
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Erk1/2/CREB/BDNF通路在CSF1R相关性白质脑病致病机制中的作用研究
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  • 项目类别:
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