Protective mechanisms of MAP kinase phosphatase 5 in adipose tissue fibrosis, hepatic steatosis and atherosclerosis

MAP激酶磷酸酶5在脂肪组织纤维化、肝脂肪变性和动脉粥样硬化中的保护机制

• 批准号: nhmrc : 1149062
• 负责人: Prof Axel Kallies
• 金额: $ 23.52万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/protective-mechanisms-map-steatosis-atherosclerosis/1321060
• 关键词: Protective; mechanisms; MAP; kinase; phosphatase

Obesity and associated complications such as diabetes, non-alcoholic fatty liver disease and atherosclerosis are a serious health burden. Recently, we found that MKP5, a molecule that restricts intracellular signaling, plays a central role in preventing these diseases. This collaborative project will elucidate how precisely MKP5 acts and explore how this molecule can be targeted for the development of novel therapeutic strategies in prevention and treatment of human metabolic diseases.

肥胖及其相关并发症，如糖尿病、非酒精性脂肪性肝病和动脉粥样硬化，是严重的健康负担。最近，我们发现MKP5，一种限制细胞内信号转导的分子，在预防这些疾病中发挥着核心作用。这一合作项目将阐明MKP5的确切作用，并探索该分子如何针对人类代谢性疾病的预防和治疗开发新的治疗策略。