Molecular pathways that control differentiation and function of tissue-resident memory T cells

控制组织驻留记忆 T 细胞分化和功能的分子途径

• 批准号: nhmrc : 1147409
• 负责人: Prof Axel Kallies
• 金额: $ 59.39万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-pathways-control-t-cells/1320844
• 关键词: Molecular; pathways; control; differentiation; function

T cells residing in organs such as gut, liver or skin guard against infection and are critical for preventing tumour development. We found that the combined activities of two factors, Blimp1 and Hobit, are critical for the development of these so-called tissue-resident T cells. Using a series of new tools, we will identify how the molecular network required for the development of tissue-resident T cell is established. This may allow us to harness their critical functions in therapy.

T细胞存在于内脏、肝脏或皮肤等器官中，防止感染，对防止肿瘤发展至关重要。我们发现，Blimp1和Hobit这两个因子的联合活动对这些所谓的组织常驻T细胞的发育至关重要。使用一系列新工具，我们将确定组织驻留T细胞发育所需的分子网络是如何建立的。这可能会让我们在治疗中利用它们的关键功能。