Regulation of metabolic dysfunction and exhaustion of virus-specific T cells during chronic infection
Regulation of metabolic dysfunction and exhaustion of virus-specific T cells during chronic infection
批准号:
nhmrc : GNT1085151
负责人:
Prof Axel Kallies
金额:
$72.1万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 --
中文摘要
点击翻译按钮获取中文摘要
英文摘要
T cells control infections and cancer cells. During chronic infection or tumor development, however, loss of function of T cells prevents efficient clearing of pathogens or cancer cells, a phenomenon termed T cell ‘exhaustion’. We have found that the regulator protein IRF4 controls cellular nutrient usage, growth and function of T cells and that very amounts of IRF4 occur in T cells during chronic infection. We propose to examine the precise role of IRF4 in chronically stimulated T cells.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Differentiation of effector and tissue regulatory T cells
-
批准号:DP210102705
-
项目类别:Discovery Projects
-
资助金额:$36.58万
-
财政年份:2021
-
负责人:Prof Axel Kallies
-
依托单位:
Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation
-
批准号:nhmrc : 1139607
-
项目类别:Research Fellowships
-
资助金额:$47.83万
-
财政年份:2018
-
负责人:Prof Axel Kallies
-
依托单位:
Protective mechanisms of MAP kinase phosphatase 5 in adipose tissue fibrosis, hepatic steatosis and atherosclerosis
-
批准号:nhmrc : 1149062
-
项目类别:Targeted Calls
-
资助金额:$23.52万
-
财政年份:2018
-
负责人:Prof Axel Kallies
-
依托单位:
Molecular pathways that control differentiation and function of tissue-resident memory T cells
-
批准号:nhmrc : 1147409
-
项目类别:Project Grants
-
资助金额:$59.39万
-
财政年份:2018
-
负责人:Prof Axel Kallies
-
依托单位:
Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation
-
批准号:nhmrc : GNT1139607
-
项目类别:Research Fellowships
-
资助金额:$70.74万
-
财政年份:2018
-
负责人:Prof Axel Kallies
-
依托单位:
Maintenance of regulatory T cells during inflammation and tumor development by IL-33
-
批准号:nhmrc : 1106378
-
项目类别:Project Grants
-
资助金额:$46.41万
-
财政年份:2016
-
负责人:Prof Axel Kallies
-
依托单位:
Maintenance of regulatory T cells during inflammation and tumor development by IL-33
-
批准号:nhmrc : GNT1106378
-
项目类别:Project Grants
-
资助金额:$67.7万
-
财政年份:2016
-
负责人:Prof Axel Kallies
-
依托单位:
Regulation of metabolic dysfunction and exhaustion of virus-specific T cells during chronic infection
-
批准号:nhmrc : 1085151
-
项目类别:Project Grants
-
资助金额:$49.95万
-
财政年份:2015
-
负责人:Prof Axel Kallies
-
依托单位:
The role of the transcription factor IRF4 in peripheral Cd8 T cell differentiation
-
批准号:nhmrc : 1032850
-
项目类别:Project Grants
-
资助金额:$26.62万
-
财政年份:2012
-
负责人:Prof Axel Kallies
-
依托单位:
Molecular and functional charcterization of a novel population of Foxp3+ regulatory T cells
-
批准号:nhmrc : 1032861
-
项目类别:Project Grants
-
资助金额:$26.29万
-
财政年份:2012
-
负责人:Prof Axel Kallies
-
依托单位:
Transcriptional and epigenetic regulation of terminal lymphocyte differentiation and alterations of the same that lead to leukemia.
-
批准号:FT0992164
-
项目类别:ARC Future Fellowships
-
资助金额:$42.43万
-
财政年份:2010
-
负责人:Prof Axel Kallies
-
依托单位:
Transcriptional Regulation of T cell Memory Programming
-
批准号:nhmrc : 637345
-
项目类别:NHMRC Project Grants
-
资助金额:$36.61万
-
财政年份:2010
-
负责人:Prof Axel Kallies
-
依托单位:
Transcriptional regulation of T lymphocyte and dendritic cell development
-
批准号:nhmrc : 637344
-
项目类别:NHMRC Project Grants
-
资助金额:$40.35万
-
财政年份:2010
-
负责人:Prof Axel Kallies
-
依托单位:
Transcriptional Regulation of Terminal T cell Differentiation by Blimp-1
-
批准号:nhmrc : 516755
-
项目类别:NHMRC Project Grants
-
资助金额:$27.43万
-
财政年份:2008
-
负责人:Prof Axel Kallies
-
依托单位:
国内基金
海外基金
登录
查看更多内容
α-酮戊二酸调控ACMSD介导犬尿氨酸通路代谢重编程在年龄相关性听力损失中的作用及机制研究
-
批准号:82371150
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:侯书乐
-
依托单位:
多囊卵巢综合征中甲酰肽受体2调控小胶质细胞代谢重编程导致GnRH神经元过度激活及HPO轴异常的病理机制研究
-
批准号:82370797
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:陶弢
-
依托单位:
NPC1调控肾上腺皮质激素分泌影响代谢稳态的机制研究
-
批准号:82370796
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:蒋怡然
-
依托单位:
衰老上皮细胞FABP4调控HSDL2致脂肪酸代谢失衡在BPH发病中的机制研究
-
批准号:82370774
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:阮渊
-
依托单位:
基于AMPK/PGC-1α信号轴的工程化外泌体靶向调控BMSCs能量代谢重编程在老年机体骨修复中的作用及其机制研究
-
批准号:82370920
-
项目类别:面上项目
-
资助金额:48.00万元
-
批准年份:2023
-
负责人:周名亮
-
依托单位:
基于影像代谢重塑可视化的延胡索酸水合酶缺陷型肾癌危险性分层模型的研究
-
批准号:82371912
-
项目类别:面上项目
-
资助金额:48.00万元
-
批准年份:2023
-
负责人:吴广宇
-
依托单位:
GPSM1介导Ca2+循环-II型肌球蛋白网络调控脂肪产热及代谢稳态的机制研究
-
批准号:82370879
-
项目类别:面上项目
-
资助金额:49.00万元
-
批准年份:2023
-
负责人:严婧
-
依托单位:
PRRC2在eIF3调控的翻译过程中的分子机制及其对肌肉健康的影响
-
批准号:32100620
-
项目类别:青年科学基金项目(C类)
-
资助金额:30.0万元
-
批准年份:2021
-
负责人:林英英
-
依托单位:
SLC38A6通过调控天冬氨酸介导的嘧啶合成促进肝癌生长的机制研究
-
批准号:32100626
-
项目类别:青年科学基金项目(C类)
-
资助金额:30.0万元
-
批准年份:2021
-
负责人:秦望舒
-
依托单位:
溶酶体贮积症细胞内胆固醇累积导致患者神经元死亡的细胞与分子机制
-
批准号:32100621
-
项目类别:青年科学基金项目(C类)
-
资助金额:30.0万元
-
批准年份:2021
-
负责人:李平
-
依托单位: