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Transcriptional Regulation of T cell Memory Programming

Transcriptional Regulation of T cell Memory Programming
T 细胞记忆编程的转录调控
批准号：
nhmrc : 637345
负责人：
Prof Axel Kallies
金额：
$36.61万
依托单位：
The Walter and Eliza Hall Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
NHMRC Project Grants
财政年份：
2010
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2010-01-01 至 2012-12-31
来源：
https://researchdata.edu.au/transcriptional-regulation-t-memory-programming/97333
关键词：
TranscriptionalRegulationcellMemoryProgramming

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中文摘要
翻译
T细胞的分化是预防疾病所必需的。一组称为转录因子的蛋白质严格调节这一基本过程，在此过程中T细胞成为效应细胞（可以杀死病原体感染的细胞）或记忆细胞（对于保护免受继发感染至关重要）。鉴定这些调节剂的功能和层次结构对于自身免疫性和感染性疾病的治疗性治疗是至关重要的，并且是本申请的目的。
英文摘要
Differentiation of T cells is required to protect against disease. A group of proteins, called transcription factors, critically regulate this fundamental process, during which T cells become effector cells (that can kill pathogen infected cells) or memory cells (that are essential for protection against secondary infections). To identify the functions and hierarchy of these regulators is critical to therapeutic treatment of autoimmune and infectious disease and is the aim of this application.
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Differentiation of effector and tissue regulatory T cells
  • 批准号：
    DP210102705
  • 项目类别：
    Discovery Projects
  • 资助金额：
    $36.58万
  • 财政年份：
    2021
  • 负责人：
    Prof Axel Kallies
  • 依托单位：
    The University of Melbourne
Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation
  • 批准号：
    nhmrc : 1139607
  • 项目类别：
    Research Fellowships
  • 资助金额：
    $47.83万
  • 财政年份：
    2018
  • 负责人：
    Prof Axel Kallies
  • 依托单位：
    The University of Melbourne
Protective mechanisms of MAP kinase phosphatase 5 in adipose tissue fibrosis, hepatic steatosis and atherosclerosis
Molecular pathways that control differentiation and function of tissue-resident memory T cells
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