Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation

效应细胞和记忆淋巴细胞分化的转录和代谢调节

• 批准号: nhmrc : GNT1139607
• 负责人: Prof Axel Kallies
• 金额: $ 70.74万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-metabolic-regulation-lymphocyte-differentiation/1348238
• 关键词: Transcriptional; metabolic; regulation; effector; memory

I am an internationally recognized expert in the field of lymphocyte biology. My work has shed light on antibody production, T cell responses and immune pathology. Specifically, I have identified molecular regulators that link antigen recognition, lymphocyte population expansion, cellular metabolism and effector function. My ongoing work focusses on the development and function of several critically important cell types, including tissue resident lymphocytes and regulatory T cells.

我是国际公认的淋巴细胞生物学专家。我的工作揭示了抗体产生，T细胞反应和免疫病理学。具体来说，我已经确定了分子调节剂，链接抗原识别，淋巴细胞群体扩增，细胞代谢和效应器功能。我正在进行的工作重点是几种至关重要的细胞类型的发育和功能，包括组织驻留淋巴细胞和调节性T细胞。