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Transcriptional Regulation of Terminal T cell Differentiation by Blimp-1

Transcriptional Regulation of Terminal T cell Differentiation by Blimp-1
Blimp-1 对 T 细胞终末分化的转录调控
批准号:
nhmrc : 516755
负责人:
Prof Axel Kallies
金额:
$27.43万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

项目摘要

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中文摘要
翻译
记忆细胞处于免疫反应的末端,决定着疫苗接种的成败。T细胞在肿瘤监测、清除感染和提供抗体分泌方面被认为是必不可少的。Blimp-1是控制效应T细胞分化的主要因子。我们的目标是研究它在记忆T细胞产生中的作用,这将有助于制定更好的免疫策略以及免疫缺陷和自身免疫的治疗。
英文摘要
Memory cells stand at the end of immune reactions and determine the success or failure of vaccination. T cells in are considered essential in tumour surveillance, clearance of infections and in providing help for antibody decretion. Blimp-1 is a major factor controling the differentiation of effector T cells. We aim to study its role in the generation of memory T cells which will help to develop better stratagies for immunization and for the treatment of immunodedeficiency and autoimmunity.
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Differentiation of effector and tissue regulatory T cells
  • 批准号:
    DP210102705
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $36.58万
  • 财政年份:
    2021
  • 负责人:
    Prof Axel Kallies
  • 依托单位:
Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation
  • 批准号:
    nhmrc : 1139607
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $47.83万
  • 财政年份:
    2018
  • 负责人:
    Prof Axel Kallies
  • 依托单位:
Protective mechanisms of MAP kinase phosphatase 5 in adipose tissue fibrosis, hepatic steatosis and atherosclerosis
Molecular pathways that control differentiation and function of tissue-resident memory T cells
海外基金