Transcriptional Regulation of Terminal T cell Differentiation by Blimp-1
Transcriptional Regulation of Terminal T cell Differentiation by Blimp-1
批准号:
nhmrc : 516755
负责人:
Prof Axel Kallies
金额:
$27.43万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
记忆细胞处于免疫反应的末端,决定着疫苗接种的成败。T细胞在肿瘤监测、清除感染和提供抗体分泌方面被认为是必不可少的。Blimp-1是控制效应T细胞分化的主要因子。我们的目标是研究它在记忆T细胞产生中的作用,这将有助于制定更好的免疫策略以及免疫缺陷和自身免疫的治疗。
英文摘要
Memory cells stand at the end of immune reactions and determine the success or failure of vaccination. T cells in are considered essential in tumour surveillance, clearance of infections and in providing help for antibody decretion. Blimp-1 is a major factor controling the differentiation of effector T cells. We aim to study its role in the generation of memory T cells which will help to develop better stratagies for immunization and for the treatment of immunodedeficiency and autoimmunity.
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Differentiation of effector and tissue regulatory T cells
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批准号:DP210102705
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项目类别:Discovery Projects
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资助金额:$36.58万
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财政年份:2021
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation
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批准号:nhmrc : 1139607
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项目类别:Research Fellowships
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资助金额:$47.83万
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财政年份:2018
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负责人:Prof Axel Kallies
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依托单位:
Protective mechanisms of MAP kinase phosphatase 5 in adipose tissue fibrosis, hepatic steatosis and atherosclerosis
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批准号:nhmrc : 1149062
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项目类别:Targeted Calls
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资助金额:$23.52万
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财政年份:2018
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负责人:Prof Axel Kallies
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依托单位:
Molecular pathways that control differentiation and function of tissue-resident memory T cells
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批准号:nhmrc : 1147409
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项目类别:Project Grants
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资助金额:$59.39万
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财政年份:2018
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional and metabolic regulation of effector and memory lymphocyte differentiation
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批准号:nhmrc : GNT1139607
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项目类别:Research Fellowships
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资助金额:$70.74万
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财政年份:2018
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负责人:Prof Axel Kallies
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依托单位:
Maintenance of regulatory T cells during inflammation and tumor development by IL-33
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批准号:nhmrc : 1106378
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项目类别:Project Grants
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资助金额:$46.41万
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财政年份:2016
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负责人:Prof Axel Kallies
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依托单位:
Maintenance of regulatory T cells during inflammation and tumor development by IL-33
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批准号:nhmrc : GNT1106378
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项目类别:Project Grants
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资助金额:$67.7万
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财政年份:2016
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负责人:Prof Axel Kallies
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依托单位:
Regulation of metabolic dysfunction and exhaustion of virus-specific T cells during chronic infection
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批准号:nhmrc : GNT1085151
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项目类别:Project Grants
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资助金额:$72.1万
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财政年份:2015
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负责人:Prof Axel Kallies
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依托单位:
Regulation of metabolic dysfunction and exhaustion of virus-specific T cells during chronic infection
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批准号:nhmrc : 1085151
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项目类别:Project Grants
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资助金额:$49.95万
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财政年份:2015
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负责人:Prof Axel Kallies
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依托单位:
The role of the transcription factor IRF4 in peripheral Cd8 T cell differentiation
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批准号:nhmrc : 1032850
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项目类别:Project Grants
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资助金额:$26.62万
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财政年份:2012
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负责人:Prof Axel Kallies
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依托单位:
Molecular and functional charcterization of a novel population of Foxp3+ regulatory T cells
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批准号:nhmrc : 1032861
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项目类别:Project Grants
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资助金额:$26.29万
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财政年份:2012
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional and epigenetic regulation of terminal lymphocyte differentiation and alterations of the same that lead to leukemia.
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批准号:FT0992164
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项目类别:ARC Future Fellowships
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资助金额:$42.43万
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财政年份:2010
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional Regulation of T cell Memory Programming
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批准号:nhmrc : 637345
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项目类别:NHMRC Project Grants
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资助金额:$36.61万
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财政年份:2010
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负责人:Prof Axel Kallies
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依托单位:
Transcriptional regulation of T lymphocyte and dendritic cell development
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批准号:nhmrc : 637344
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项目类别:NHMRC Project Grants
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资助金额:$40.35万
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财政年份:2010
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负责人:Prof Axel Kallies
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依托单位:
海外基金