CSHL 2011 Cellular Biology of Addiction Course

描述(由申请者提供)：拟举办的研讨会的主要目的是对吸毒成瘾的细胞和分子生物学的基本原理、最新进展和主要空白进行深入讨论。研讨会面向新的和有经验的研究人员，将结合正式陈述和非正式讨论，传达细胞和分子方法在药物成瘾研究中的优点和兴奋之处。研讨会将强调这种方法的重要性，不仅是对于代价最高的神经精神障碍--成瘾，而且还包括它对学习、记忆、奖赏的神经化学关联、感知和其他神经科学学科的适用性。对药物反应所发生的分子和细胞变化的研究对于澄清适应过程是否对于成瘾的每个阶段和每种药物的滥用是不同的至关重要。随着基因组学和蛋白质组学的出现，现在有一个非同寻常的机会来开发成瘾、渴望和复发药物使用的基本神经适应过程的综合模型。研讨会将为与会者提供一系列学科，有助于开发吸毒成瘾每个阶段的综合模型。将介绍以下学科：1.成瘾概述。2.滥用药物的神经适应。3.药物神经适应与行为表现的关系4.药物成瘾或药物反应的基因/易感性。5.细胞水平的耐受性、敏感化和适应性。6.新的受体靶点。7.治疗药物滥用的药物发现和开发：细胞生物学如何起作用？该研讨会将对成瘾的神经适应性反应的当前研究和新研究提供综合观点，促进关于协作和整合的讨论，并提供构建成瘾作为一种疾病的模型和生物治疗的新分子靶点所需的关键信息。在科学努力的层面之外，这些信息对于制定公共政策和让公众了解吸毒和成瘾的神经生物学后果至关重要。拟议中的研讨会将引起人们的浓厚兴趣，为合作开辟渠道，并为研究成瘾的神经生物学提供新的途径。研讨会特别努力纳入不同的参与者群体，特别注意纳入妇女、美国少数群体以及国内和国际科学家的良好平衡。 与公共健康相关：吸毒成瘾和滥用的社会后果是巨大的。在过去的三十年里，行为研究在成瘾研究领域占据主导地位。随着分子神经科学在过去二十年中的快速发展和2003年人类基因组的完成，行为或生理反应与分子遗传和细胞反应之间的整合越来越可能和相关。这些学科的融合需要对每种方法的优缺点有深刻的认识。研讨会的主题是在成瘾药物的行为影响的框架内，向与会者提供有关组织、细胞和基因如何对滥用药物作出反应的最新信息。这个为期一周的住宅研讨会面向新的和有经验的调查人员，并结合正式演讲和非正式讨论，传达细胞和分子方法在药物成瘾研究中的优点和兴奋之处。研讨会将强调这种方法的重要性，不仅是对代价最高的神经精神障碍--成瘾，而且是对学习、记忆和神经科学的其他学科的适用性。对药物反应所发生的分子和细胞变化的研究对于澄清适应过程是否对于成瘾的每个阶段和每种药物的滥用是不同的至关重要。最终，对这些疾病的新治疗方法可能会出现在对药物滥用和成瘾过程中出现问题的潜在过程的更好理解上。

DESCRIPTION (provided by applicant): The primary objective of the proposed workshop is to provide an intense discussion of the fundamentals, state-of-the-art advances and major gaps in the cell and molecular biology of drug addiction. Targeted to both new and experienced investigators, the workshop will combine formal presentations and informal discussions to convey the merits and excitement of cellular and molecular approaches to drug addiction research. The workshop will stress the significance of this approach not only to the most costly neuropsychiatric disorder, addiction, but its applicability to learning, memory, neurochemical correlates of reward, perception and other disciplines of neuroscience. Research on the molecular and cellular changes that occur in response to drugs is critical for clarifying whether adaptive processes are diverse for each stage of addiction and for each drug of abuse. With the advent of genomics and proteomics, an extraordinary opportunity now exists to develop comprehensive models of neuroadaptative processes fundamental to addiction, craving, and relapse to drug use. The workshop will provide attendees with a spectrum of disciplines that can contribute to developing comprehensive models of each stage of drug addiction. The following disciplines will be presented: 1.Overview of addiction. 2. Neuroadaptation to drugs of abuse. 3. Association between drug-induced neuroadaptation and behavioral manifestations 4. Genotype/susceptibility to drug addiction or drug response. 5. Tolerance, sensitization and adaptation at the cellular level. 6. New receptor targets. 7. Drug discovery and development to treat drug abuse: how can cell biology contribute? This workshop will provide an integrated view of current and novel research on neuroadaptive responses to addiction, foster discussion on collaboration and integration and provide critical information needed to construct a model of addiction as a disease and novel molecular targets for biological treatments. Beyond the plane of scientific endeavor, such information is vital for formulating public policy and for enlightening the public on the neurobiological consequences of drug use and addiction. The proposed workshop will generate intense interest, open conduits for collaborations and novel routes to investigating the neurobiology of addiction. The workshop makes particular efforts to include a diverse group of participants, being particularly mindful of the inclusion of women, US minorities and a good balance of national and international scientists. PUBLIC HEALTH RELEVANCE: The societal consequences of drug addiction and abuse are enormous. Over the past thirty years, behavioral studies have tended to dominate the field of addiction research. With the rapid growth in molecular neuroscience in the last two decades and the completion of the human genome in 2003, integration between behavioral or physiological responses and molecular genetic and cellular responses is increasingly possible and relevant. Amalgamation of these disciplines requires a profound appreciation for the strengths and weaknesses of each approach. The theme of the workshop is to provide attendees with the most up-to-date information on how tissues, cells and genes respond to drugs of abuse, within the framework of the behavioral effects of addictive drugs. This week-long residential workshop is targeted to both new and experienced investigators, and combines formal presentations and informal discussions to convey the merits and excitement of cellular and molecular approaches to drug addiction research. The workshop will stress the significance of this approach not only to the most costly neuropsychiatric disorder, addiction, but its applicability to learning, memory, and other disciplines of neuroscience. Research on the molecular and cellular changes that occur in response to drugs is critical for clarifying whether adaptive processes are diverse for each stage of addiction and for each drug of abuse. Ultimately, new treatments for these disorders are likely to emerge from a better understanding of the underlying processes that go awry during substance abuse and addiction.