Viper Resource Grant at Texas A&M University-Kingsville

德克萨斯州 A 的 Viper 资源补助金

• 批准号: 10368961
• 负责人: Elda E. Sanchez
• 金额: $ 52.93万
• 依托单位: TEXAS A&M UNIVERSITY-KINGSVILLE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10368961
• 关键词: Address; American; Animals; Antibodies; Antivenins; Applied Research; Basic Science; Biocompatible Materials; Biological Assay; Biomedical Research; Cell Surface Receptors; Cells; Clinical Research; Collection; Complex; Crotalid; Development; Discipline; Evolution; Faculty; Funding; Genomics; Goals; Grant; Growth; Health; Human; IACUC; In Vitro; Individual; International; Methods; Military Personnel; Molecular Probes; Nociception; Pharmaceutical Preparations; Physiological; Play; Process; Production; Proteins; Proteomics; Provider; Recombinants; Reproducibility; Research; Research Personnel; Resources; Role; Scientist; Services; Snake Venoms; Snakes; Source; Specificity; Testing; Texas; Therapeutic; Therapeutic Human Experimentation; Toxin; Toxinology; Training; Translational Research; Underrepresented Students; United States National Institutes of Health; Universities; Venoms; base; biological research; experience; interest; novel; novel drug class; novel therapeutics; outreach program; programs; service programs

The National Natural Toxins Research Center (NNTRC), a component of Texas A&M University–Kingsville (TAMUK), is a unique animal and biological material resource center organized to support basic and translational research on venomous snakes and their venoms. Since the initiation of this P40 grant in 2003, the NNTRC has served as the only federally-funded viper resource center in the U.S., playing a critical role as a provider of high quality single-source venoms and snake-related research materials to national and international biomedical and biological research programs. The goal of the NNTRC is to provide native venom and purified venom components, recombinant venom proteins and specialized venom research services of the highest quality to support snake venom – related research in the US and abroad To achieve its goal the NNTRC will address the following three Specific Aims: Aim #1 To operate the National Natural Toxins Research Center as a resource center that provides high quality venom and products that support biological and biomedical research for national and International research programs. Aim #2 To develop and expand the collection of snakes, specialized services and outreach programs to support growth of venom related research in the U.S. Aim #3 To conduct a state-of-the-art applied research program to support the development of new venom-related research services To address these aims the NNTRC has assembled a team of skilled and experienced scientists and research staff with specialized expertise in the management of venomous snakes and the collection and characterization of snake venoms and anti-venoms. It has also assembled a comprehensive collection of North American venomous snakes, more than 450 animals representing 21 different species consisting of 36 subspecies, maintained under IACUC-approved conditions in a state-of-the-art research vivarium. The NNTRC is recognized as a reputable and reliable source for both venom-related products and specialized services that are used by academic and commercial research programs to support the development of new drugs and anti-venom therapeutics. The resources of the NNTRC have been applied to research in a wide range of disciplines ranging from genomic and proteomic studies on venom evolution to translational research on nociception and anti-venom therapeutics, research that has been supported by multiple NIH I/C's, the NSF, Dept of Defense and national and international research agencies. In addition to its role as a national resource for venom research and as a center of toxinology research, the NNTRC has also played an important role in providing opportunities for underrepresented students and faculty to gain training in the field of biomedical research.

国家天然毒素研究中心 (NNTRC)，德克萨斯 A&M 大学金斯维尔分校的组成部分 （TAMUK），是一个独特的动物和生物材料资源中心，旨在支持基础和 毒蛇及其毒液的转化研究。自 2003 年启动这项 P40 赠款以来， NNTRC 是美国唯一一家由联邦政府资助的毒蛇资源中心，在 向国家和地区提供高质量的单一来源毒液和蛇相关研究材料 国际生物医学和生物学研究计划。 NNTRC 的目标是提供本地 毒液和纯化的毒液成分、重组毒液蛋白和专门的毒液研究 支持美国和国外蛇毒相关研究的最高质量服务 为了实现其目标，NNTRC 将实现以下三个具体目标： 目标#1 将国家天然毒素研究中心作为一个资源中心来运营，提供高 支持国内和国际生物和生物医学研究的优质毒液和产品 研究计划。 目标#2 开发和扩大蛇的收藏、专业服务和外展计划 支持美国毒液相关研究的发展 目标#3 开展最先进的应用研究计划，以支持新产品的开发 毒液相关研究服务 为了实现这些目标，NNTRC 组建了一支由技术精湛、经验丰富的科学家和研究人员组成的团队 具有毒蛇管理以及毒蛇收集和特性鉴定方面专业知识的工作人员 蛇毒和抗蛇毒血清。它还收集了北美有毒的全面集合 蛇，超过 450 种动物，代表 21 个不同物种，包括 36 个亚种，在 IACUC 批准的最先进的研究动物园条件。 NNTRC 被公认为信誉良好的 学术界和学术界使用的毒液相关产品和专业服务的可靠来源 支持新药和抗蛇毒疗法开发的商业研究计划。 NNTRC 的资源已应用于广泛学科的研究，包括： 毒液进化的基因组和蛋白质组学研究到伤害感受和抗毒液的转化研究 治疗学、研究得到了多个 NIH I/C、NSF、国防部和国家 和国际研究机构。除了作为毒液研究的国家资源和作为 作为毒理学研究中心，NNTRC 在为毒理学研究提供机会方面也发挥了重要作用。 代表性不足的学生和教师获得生物医学研究领域的培训。