Viper Resource Grant at Texas A&M University-Kingsville

德克萨斯州 A 的 Viper 资源补助金

• 批准号: 10569528
• 负责人: Elda E. Sanchez
• 金额: $ 52.93万
• 依托单位: TEXAS A&M UNIVERSITY-KINGSVILLE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10569528
• 关键词: Address; American; Animals; Antibodies; Antivenins; Applied Research; Basic Science; Biocompatible Materials; Biological Assay; Biomedical Research; Cell Surface Receptors; Cells; Clinical Research; Collection; Complex; Crotalid; Development; Discipline; Evolution; Faculty; Funding; Genomics; Goals; Grant; Growth; Health; Human; IACUC; In Vitro; Individual; International; Methods; Military Personnel; Molecular Probes; Nociception; Pharmaceutical Preparations; Physiological; Play; Process; Production; Proteins; Proteomics; Provider; Recombinants; Reproducibility; Research; Research Personnel; Resources; Role; Scientist; Services; Snake Venoms; Snakes; Source; Specificity; Testing; Texas; Therapeutic; Toxin; Toxinology; Training; Translational Research; Underrepresented Students; United States National Institutes of Health; Universities; Venoms; biological research; experience; improved; interest; novel; novel drug class; novel therapeutics; outreach program; programs; service programs; skills

The National Natural Toxins Research Center (NNTRC), a component of Texas A&M University–Kingsville (TAMUK), is a unique animal and biological material resource center organized to support basic and translational research on venomous snakes and their venoms. Since the initiation of this P40 grant in 2003, the NNTRC has served as the only federally-funded viper resource center in the U.S., playing a critical role as a provider of high quality single-source venoms and snake-related research materials to national and international biomedical and biological research programs. The goal of the NNTRC is to provide native venom and purified venom components, recombinant venom proteins and specialized venom research services of the highest quality to support snake venom – related research in the US and abroad To achieve its goal the NNTRC will address the following three Specific Aims: Aim #1 To operate the National Natural Toxins Research Center as a resource center that provides high quality venom and products that support biological and biomedical research for national and International research programs. Aim #2 To develop and expand the collection of snakes, specialized services and outreach programs to support growth of venom related research in the U.S. Aim #3 To conduct a state-of-the-art applied research program to support the development of new venom-related research services To address these aims the NNTRC has assembled a team of skilled and experienced scientists and research staff with specialized expertise in the management of venomous snakes and the collection and characterization of snake venoms and anti-venoms. It has also assembled a comprehensive collection of North American venomous snakes, more than 450 animals representing 21 different species consisting of 36 subspecies, maintained under IACUC-approved conditions in a state-of-the-art research vivarium. The NNTRC is recognized as a reputable and reliable source for both venom-related products and specialized services that are used by academic and commercial research programs to support the development of new drugs and anti-venom therapeutics. The resources of the NNTRC have been applied to research in a wide range of disciplines ranging from genomic and proteomic studies on venom evolution to translational research on nociception and anti-venom therapeutics, research that has been supported by multiple NIH I/C's, the NSF, Dept of Defense and national and international research agencies. In addition to its role as a national resource for venom research and as a center of toxinology research, the NNTRC has also played an important role in providing opportunities for underrepresented students and faculty to gain training in the field of biomedical research.

国家天然毒素研究中心（NNTRC），德克萨斯A&M大学金斯维尔分校的一个组成部分 （TAMUK），是一个独特的动物和生物材料资源中心，组织起来，以支持基本和 对毒蛇及其毒液的转化研究。自2003年启动P40赠款以来， NNTRC是美国唯一一个由联邦政府资助的毒蛇资源中心，作为一个 提供高品质的单一来源毒液和蛇相关的研究材料，以国家和 国际生物医学和生物学研究计划。NNTRC的目标是提供本地 毒液和纯化毒液成分、重组毒液蛋白和专门的毒液研究 提供最高质量的服务，以支持美国和国外的蛇毒相关研究 为了实现其目标，NNTRC将致力于以下三个具体目标： 目标#1将国家天然毒素研究中心作为一个资源中心， 优质毒液和产品，支持国家和国际生物和生物医学研究 研究项目。 目标#2发展和扩大蛇的收集，专业服务和外展计划 以支持美国毒液相关研究的发展。 目标#3进行最先进的应用研究计划，以支持开发新的 与毒液有关的研究服务 为了实现这些目标，NNTRC组建了一个由熟练和经验丰富的科学家和研究人员组成的团队。 在毒蛇管理以及毒蛇的收集和定性方面具有专门知识的工作人员 蛇毒和抗蛇毒血清它还收集了北美有毒的 蛇，超过450种动物，代表21个不同的物种，包括36个亚种， IACUC批准的条件下在最先进的研究动物园。NNTRC被公认为是一个信誉良好的 和可靠的来源，为毒液相关的产品和专业服务，所使用的学术和 商业研究计划，以支持新药物和抗蛇毒疗法的开发。 NNTRC的资源已应用于广泛学科的研究， 从毒液进化的基因组学和蛋白质组学研究到伤害感受和抗蛇毒血清的转化研究 治疗学，研究已经得到了多个NIH I/C，NSF，国防部和国家卫生部的支持。 国际研究机构。除了作为毒液研究的国家资源和 作为毒理学研究中心，NNTRC在提供机会方面也发挥了重要作用， 在生物医学研究领域，教科文组织鼓励代表性不足的学生和教师接受培训。