A Supplement Proposal for an Air Conditioning Unit, Cage Washer, Incubator and HPLC Systems to Support Research and Education Programs at Texas A&M University-Kingsville

关于空调装置、笼式清洗机、培养箱和 HPLC 系统的补充提案，以支持德克萨斯大学的研究和教育项目

• 批准号: 10405841
• 负责人: Elda E. Sanchez
• 金额: $ 18.99万
• 依托单位: TEXAS A&M UNIVERSITY-KINGSVILLE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10405841
• 关键词: Air Conditioning; Animal Experimentation; Animal Husbandry; Animals; Antivenins; Applied Research; Area; Biochemistry; Biomedical Research; Collection; Complex; Development; Discipline; Drug Design; Education; Equipment; Evolution; Faculty; Foundations; Genomics; Growth; Health; High Pressure Liquid Chromatography; Inbred BALB C Mice; Incubators; International; Molecular Biology; Molecular Probes; Mus; Natural Products; New Brunswick; Nociception; Personal Satisfaction; Pharmaceutical Preparations; Physiological; Process; Proteomics; Recombinants; Reproducibility; Research; Research Personnel; Research Support; Resources; Role; Services; Snake Venoms; Snakes; System; Texas; Therapeutic; Therapeutic Human Experimentation; Toxin; Training; Translational Research; United States National Institutes of Health; Universities; Venoms; biological research; design; instrument; instrumentation; novel; outreach program; parent grant; programs; research study; service programs; undergraduate student

PROJECT SUMMARY: Natural products have been a main foundation of drug design and snakes as well as other animal venoms have a vast unexploited potential. The fields of venom and anti-venom research are absolutely dependent on access to the reliable and reproducible venom-related resources developed by the National Natural Toxin Research Center (NNTRC). Snake venoms have provided molecular probes that have been used to decipher numerous complex physiological and pathophysiological processes and have served as the starting point for the development of several important classes of drugs. The NNTRC is in need of equipment and instrumentation crucial for maintaining the health and well-being of over 450 venomous snakes and ~1000 BALB/c mice used for research resources. The instrumentation is needed for purifying venom toxins and expressing recombinant novel molecules. The equipment and instrumentation being requested, a Daikin 8 Ton VRC Air conditioning Unit, a Tecniplast Cage Washer, a New Brunswick Innova® Incubator, and two ThermoFisher Binary High Performance Liquid Chromatography Systems, in the proposal are ideally suited to support critical research by sustaining the NNTRC's research animals in top quality conditions, purifying venom molecules, and designing novel recombinant molecules that can be used in therapeutics. The specific aims for the parent grant are to: 1) operate the National Natural Toxins Research Center as a resource center that provides high quality venom and products that support biological and biomedical research to national and international programs; 2) develop and expand the collection of snakes, specialized services and outreach programs to support growth of venom related research in the U.S.; and 3) conduct a state-of-the-art applied research program to support the development of new venom-related research services. Access to these equipment and instruments will enable the NNTRC to fulfill its specific aims and allow researchers to make important advances in the search for venom-derived therapeutics. RELEVANCE: The resources of the NNTRC have been applied to research in a wide range of disciplines ranging from genomic and proteomic studies on venom evolution to translational research on nociception and anti-venom therapeutics, research that has been supported by multiple NIH I/C's, the NSF, Dept of Defense and national and international research agencies. In addition to its roles as a national resource and keeping the animals healthy, the instruments will provide undergraduate, graduate and faculty from underrepresented areas with the opportunity to understand, venom biochemistry and molecular biology, and for hands-on training with animal husbandry.

项目概要： 天然产物已成为药物设计的主要基础，蛇以及其他动物毒液 有巨大的未开发潜力。毒液和抗毒血清的研究领域完全依赖于 获得国家天然毒素中心开发的可靠和可再生的毒液相关资源 研究中心（NNTRC）。蛇毒提供了分子探针， 许多复杂的生理和病理生理过程，并已作为起点， 几类重要药物的开发。NNTRC需要设备， 这些仪器对维持450多条毒蛇和1000多条毒蛇的健康和福祉至关重要。 用于研究资源的BALB/c小鼠。净化毒液所需的仪器， 表达重组新分子。所要求的设备和仪器，一台大金8 Ton VRC空调机组、Tecniplast笼式清洗机、新不伦瑞克Innova®培养箱，以及 两个赛默飞世尔二元高效液相色谱系统，在该提案中是理想的 适合通过维持NNTRC的研究动物在最高质量的条件下支持关键研究， 纯化毒液分子和设计可用于治疗的新型重组分子。的 家长补助金的具体目标是：1）将国家天然毒素研究中心作为一种资源 该中心提供高质量的毒液和产品，支持生物和生物医学研究， 国家和国际方案; 2）发展和扩大蛇的收集，专业服务， 支持美国毒液相关研究发展的外展计划;以及3）进行最先进的 应用研究计划，以支持发展与毒液有关的新研究服务。获得 这些设备和仪器将使NNTRC能够实现其特定目标，并使研究人员能够 在寻找毒液衍生疗法方面取得了重要进展。 相关性： NNTRC的资源已应用于广泛学科的研究， 从毒液进化的基因组学和蛋白质组学研究到伤害感受和抗蛇毒血清的转化研究 治疗学，研究已经得到了多个NIH I/C，NSF，国防部和国家卫生部的支持。 国际研究机构。除了作为国家资源和饲养动物的作用外， 健康，这些工具将提供本科生，研究生和教师从代表性不足的地区， 有机会了解，毒液生物化学和分子生物学，并进行实践培训， 畜牧业