Instrumentation to Support the Research and Resources of the Viper Resource Center at Texas A&M University-Kingsville

支持德克萨斯州 Viper 资源中心研究和资源的仪器

• 批准号: 10601327
• 负责人: Elda E. Sanchez
• 金额: $ 17.21万
• 依托单位: TEXAS A&M UNIVERSITY-KINGSVILLE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10601327
• 关键词: Animals; Antivenins; Applied Research; Area; Biomedical Research; Collection; Complex; Development; Discipline; Drug Design; Equipment; Evolution; Faculty; Foundations; Freeze Drying; Functional disorder; Genomics; Growth; International; Molecular Probes; Natural Products; Nociception; Pharmaceutical Preparations; Physiological; Play; Process; Proteomics; Reproducibility; Research; Research Personnel; Research Support; Resources; Role; Services; Snake Venoms; Snakes; Texas; Therapeutic; Therapeutic Human Experimentation; Toxin; Translational Research; United States National Institutes of Health; Universities; Venoms; biological research; design; drug development; extracellular vesicles; instrument; instrumentation; nanoparticle; novel therapeutics; outreach program; parent grant; programs; service programs; synergism; therapeutic development; undergraduate student

Title: Instrumentation to Support the Research and Resources of the Viper Resource Center at Texas A&M University-Kingsville PROJECT SUMMARY: Natural products have been a main foundation of drug design and snakes as well as other animal venoms have a vast unexploited potential. The fields of venom and anti-venom research are absolutely dependent on access to the reliable and reproducible venom-related resources developed by the National Natural Toxin Research Center (NNTRC). Snake venoms have provided molecular probes that have been used to decipher numerous complex physiological and pathophysiological processes and have served as the starting point for the development of several important classes of drugs. The NNTRC is in need of equipment crucial for advancing the level of research as well as continuing to provide high-quality research resources to its customers. The equipment and instrumentation being requested, Optima MAX-XP Tabletop Ultracentrifuge, a NANOSIGHT NS300 Nanoparticle Tracking Analysis (NTA), and one LabConco® lyophilizers, in the proposal are ideally suited to support and take research at the NNTRC to the next level. The specific aims for the parent grant are to: 1) operate the National Natural Toxins Research Center as a resource center that provides high quality venom and products that support biological and biomedical research to national and international programs; 2) develop and expand the collection of snakes, specialized services and outreach programs to support growth of venom related research in the U.S.; and 3) conduct a state-of-the-art applied research program to support the development of new venom-related research services. Access to these equipment and instruments will enable the NNTRC to fulfill its specific aims and allow researchers to make important advances in the search for venom-derived therapeutics. RELEVANCE: The resources of the NNTRC have been applied to research in a wide range of disciplines ranging from genomic and proteomic studies on venom evolution to translational research on nociception and anti-venom therapeutics, research that has been supported by multiple NIH I/C’s, the NSF, Dept of Defense, and national and international research agencies. In addition to its roles as a national viper and venom resource, the instruments will provide undergraduate, graduate and faculty from underrepresented areas with the opportunity to participate in state-of- the-art research and further understand the mechanisms of toxins and their roles in the pathophysiology of snake envenoming in order to design next generation therapeutics.

标题：用于支持研究的仪器和毒蛇资源中心的资源 德克萨斯农工大学金斯维尔分校 项目概要： 天然产物已成为药物设计和蛇类等的主要基础 动物毒液具有巨大的未开发潜力。毒液和抗蛇毒血清研究领域 绝对依赖于获得可靠和可再生的毒液相关资源， 国家天然毒素研究中心（NNTRC）蛇毒具有 提供了分子探针，这些探针已被用于破译许多复杂的生理学， 和病理生理过程，并已作为发展的起点， 几种重要的毒品。NNTRC需要关键的设备来推进 研究水平，并继续提供高质量的研究资源， 客户所要求的设备和仪器，Optima MAX-XP桌面 Ultracentrance，NANOSIGHT NS 300纳米颗粒跟踪分析（NTA），和一个 LabConco®冻干机，在提案中是理想的适合支持和采取研究在 NNTRC到下一个级别。父母补助金的具体目标是：（1）管理国家 天然毒素研究中心作为一个资源中心，提供高品质的毒液， 支持生物和生物医学研究的产品，以国家和国际计划; 2)开发和扩大蛇的收藏、专业服务和外展计划， 支持美国毒液相关研究的发展;和3）进行最先进的应用 研究计划，以支持开发新的毒液相关研究服务。接入 这些设备和仪器将使NNTRC能够实现其特定目标， 研究人员在寻找毒液衍生疗法方面取得了重要进展。 相关性： NNTRC的资源已应用于广泛学科的研究 从毒液进化的基因组和蛋白质组学研究到 伤害感受和抗蛇毒治疗，研究已得到多个国家卫生研究院支持 I/C、NSF、国防部以及国家和国际研究机构。除了 它作为国家毒蛇和毒液资源的角色，这些仪器将为本科生， 来自代表性不足地区的毕业生和教师有机会参加国家 最先进的研究，并进一步了解毒素的机制及其在 蛇毒液中毒的病理生理学，以设计下一代治疗方法。