Novel Approaches Against Emerging Antimicrobial Resistance

对抗新出现的抗菌素耐药性的新方法

• 批准号: 10391767
• 负责人: Thale Cross Jarvis
• 金额: $ 1.1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10391767
• 关键词: Academia; Address; Alberta province; Antibiotic Resistance; Antibiotics; Antibodies; Antimicrobial Resistance; Artificial Intelligence; Bacteriophages; Biology; COVID-19 therapeutics; COVID-19 vaccine; Canada; Career Choice; Chemicals; Clinical Pathways; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communicable Diseases; Development; Diagnostic; Ecology; Educational workshop; Environment; Evolution; Funding Agency; Goals; Government; Health; Human; Human Microbiome; Industry; Infection; Knowledge; Learning; Mentors; Methodology; Modality; Outcome; Policy Maker; Program Development; Rapid diagnostics; Regulatory Pathway; Research; Research Personnel; Resistance; Source; System; Therapeutic; Thinking; Vaccines; Work; World Health Organization; antimicrobial; authority; clinical development; clinical practice; diagnostic tool; drug resistant microorganism; effective therapy; emerging antimicrobial resistance; food security; global health; innovation; man; microbiome; new technology; next generation; novel; novel strategies; novel therapeutics; posters; public-private partnership; stem; success; symposium; therapeutic development

ABSTRACT Support is requested for a Keystone Symposia conference entitled Novel Approaches Against Emerging Antimicrobial Resistance, organized by Drs. Man-Wah Tan and Deborah T. Hung. The conference will be held in Banff, Alberta, Canada from February 13-16, 2022. It has become clear that infectious diseases are among the greatest threats to human health and global stability. Chief among these threats is the rise in antibiotic resistance, which endangers our ability to treat otherwise curable infections. The capacity to discover and develop novel agents to fill the pipeline as existing antibiotics are lost to increasing resistance has to date been limited. The goal of this Keystone Symposia conference is to present cutting-edge approaches to antibiotic discovery, including application of expanded chemical space, systems chemical biology, and artificial intelligence and novel strategies for treating resistant infection, including CRISPR, vaccines, antibodies, phages and conjugates. The promise, challenges, and development paths of these new approaches and strategies will be discussed in the context of lessons learned from prior antibiotic development programs, and new innovations in clinical and regulatory pathways. Additionally, this conference will be held jointly with “The Human Microbiome: Ecology and Evolution.” This pairing will help to facilitate exploration of the impact of antibiotics on the microbiome and the microbiome on antibiotic resistance.

抽象的 请求支持题为“针对新兴市场的新方法”的 Keystone 研讨会 抗菌素耐药性，由 Drs 组织。陈曼华和黛博拉·洪。会议将举行 2022 年 2 月 13 日至 16 日在加拿大艾伯塔省班夫举行。 显而易见，传染病是对人类健康和全球的最大威胁之一。 稳定。这些威胁中最主要的是抗生素耐药性的上升，这危及我们的治疗能力 其他可治愈的感染。发现和开发新药物以填补现有管道的能力 迄今为止，抗生素因耐药性增加而丧失的情况仍然有限。本次 Keystone 研讨会的目标 会议将介绍抗生素发现的前沿方法，包括扩展的应用 化学空间、系统化学生物学、人工智能和治疗耐药性的新策略 感染，包括 CRISPR、疫苗、抗体、噬菌体和结合物。承诺、挑战和 将结合经验教训讨论这些新方法和战略的发展路径 来自先前的抗生素开发计划以及临床和监管途径的新创新。 此外，本次会议还将与“人类微生物组：生态与进化”联合举办。这 配对将有助于促进探索抗生素对微生物组的影响以及微生物组对 抗生素耐药性。