Novel Approaches Against Emerging Antimicrobial Resistance

摘要 要求为题为“新的办法对付新兴的 抗生素耐药性，由Man-Wah Tan和Deborah T.洪。举行这次会议 2022年2月13日至16日在加拿大阿尔伯塔班夫举行。 很明显，传染病是对人类健康和全球环境的最大威胁之一。 稳定这些威胁中最主要的是抗生素耐药性的上升，这危及我们治疗疾病的能力。 其他可治愈的感染发现和开发新制剂以填补现有管道的能力 抗生素失去增加的耐药性迄今为止是有限的。本次Keystone研讨会的目标是 会议将介绍抗生素发现的尖端方法，包括扩大抗生素的应用。 化学空间，系统化学生物学，人工智能和治疗耐药的新策略 感染，包括CRISPR，疫苗，抗体，抗体和缀合物。承诺、挑战和 将结合经验教训讨论这些新方法和战略的发展路径 从以前的抗生素开发计划，以及临床和监管途径的新创新。 此外，本次会议将与“人类微生物组：生态学与进化”联合举行。这 配对将有助于探索抗生素对微生物组的影响以及微生物组对 抗生素耐药性

ABSTRACT Support is requested for a Keystone Symposia conference entitled Novel Approaches Against Emerging Antimicrobial Resistance, organized by Drs. Man-Wah Tan and Deborah T. Hung. The conference will be held in Banff, Alberta, Canada from February 13-16, 2022. It has become clear that infectious diseases are among the greatest threats to human health and global stability. Chief among these threats is the rise in antibiotic resistance, which endangers our ability to treat otherwise curable infections. The capacity to discover and develop novel agents to fill the pipeline as existing antibiotics are lost to increasing resistance has to date been limited. The goal of this Keystone Symposia conference is to present cutting-edge approaches to antibiotic discovery, including application of expanded chemical space, systems chemical biology, and artificial intelligence and novel strategies for treating resistant infection, including CRISPR, vaccines, antibodies, phages and conjugates. The promise, challenges, and development paths of these new approaches and strategies will be discussed in the context of lessons learned from prior antibiotic development programs, and new innovations in clinical and regulatory pathways. Additionally, this conference will be held jointly with “The Human Microbiome: Ecology and Evolution.” This pairing will help to facilitate exploration of the impact of antibiotics on the microbiome and the microbiome on antibiotic resistance.