Pharmacological Sciences Training Program (PSTP)

项目摘要 乔治敦大学医学中心的药理学科学培训计划（PSTP）是新的， 跨学科和综合计划，将汇集一个包容性和多样化的博士社区 博士候选人致力于药理学论文研究的学科。教师 PSTP的导师在确定细胞信号通路中的药物靶点方面具有主要的研究优势 来治疗人类疾病该计划的28名导师和11名教师都有很强的历史， 在疾病治疗药物开发方面的指导和研究计划，每年超过3000万美元 科研经费该计划的学员来自博士生。药理学和生理学课程， 生物化学、肿瘤生物学和神经科学。学员将为未来在学术界，制药业和制药业的职业生涯做准备。 或生物技术行业，或药品监管机构。这项申请旨在每年资助六个博士前 学生，提供了一个催化剂，使四个馈线计划，并将是唯一的NIGMS T32在 顾学员将在研究生院的第二年进入该计划， 和第三年，并将在整个学位的其余部分持续参与。学员参加 药理学科学的一套全面的核心课程，生理/生物化学原理， 药理学，以及与其研究相关的药理学专业选修课。认识到 药理学科学的跨学科性质，学生将有更多的接触生物信息学， 分子和细胞生物学，以及整合药理学的生物统计学。我们的课程视野开阔 从细胞网络到器官功能，再到行为和系统医学。培训将提高他们的 了解特定于其学习和研究领域的药物机制，并使他们能够表征 疾病中的新药物靶点和信号通路。学员和导师将参加结构化的 导师培训。在支持期间，所有学员将有两个专门的实习区：一部分- 时间，学期长的安置将发生在乔治敦（例如，法规事务、技术商业化）; 第二个阶段是在当地合作机构（生物技术、政府、基金会）进行暑期实习。 因此，我们的学员将在职业道路上获得广泛的可转移技能，同时发展他们的 研究能力。我们已经设定了计划目标，包括（1）在5.5年内实现95%的学位 （2）在我们的学员库中实现30%的代表性不足群体，（3）实现 指导人员和受训人员100%参加正式指导人员培训，（4）出版4份影响力大的出版物 每名学员，（5）在获得学位的两年内实现75%的药理学相关职业安置，（6） 继续扩大我们的实习机会，以及（7）增加研究生教育中最佳实践的采用 招生我们致力于培养下一代药理学科学家， 乔治城大学在药理学方面长期成功的记录。

Project Summary The Pharmacological Sciences Training Program (PSTP) at Georgetown University Medical Center is new, interdisciplinary and integrated program that will bring together an inclusive and diverse community of doctoral candidates across Ph.D. disciplines who are dedicated to thesis research in pharmacological science. Faculty mentors in the PSTP share major research strengths in identifying drug targets within cellular signaling pathways to treat human disease. The 28 mentor and 11 preceptor faculty in the program all have a strong history of mentorship and research programs in drug development for disease treatment with >$30 million in annual research funding. Trainees in the program are drawn from Ph.D. programs in Pharmacology & Physiology, Biochemistry, Tumor Biology, and Neuroscience. Trainees will prepare for future careers in academia, pharma or biotechnology industry, or drug regulatory agencies. This application seeks annual funding for six predoctoral students, providing a catalyst to bring together the four feeder programs, and would be the only NIGMS T32 at GU. Trainees will enter the program in their second year of graduate school, will be supported for their second and third years, and will have ongoing participation throughout the remainder of their degree. Trainees take a comprehensive set of core courses in pharmacological sciences, physiological/biochemical principles integral to pharmacology, and specialized electives in pharmacology relevant to their research. Recognizing the interdisciplinary nature of pharmacological sciences, students will have additional exposure to bioinformatics, molecular and cellular biology, and biostatistics that integrate pharmacology. Our courses take a wide view ranging from cellular networks to organ function to behavior and systems medicine. Training will enhance their understanding of drug mechanisms specific to their field of study and research, and enable them to characterize novel drug targets and signaling pathways in disease. Both trainees and mentors will participate in structured mentor training. During the period of support, all trainees will have two dedicated blocks for internships: one part- time, semester-long placement will occur at Georgetown (e.g., regulatory affairs, technology commercialization); the second block will be summer internship at a local partnering institution (biotech, government, foundations). Thus, our trainees will gain broad exposure to transferable skills across career paths while developing their research abilities. We have set program goals to include (1) achieving a 95% degree attainment within 5.5 years of matriculation, (2) achieving 30% representation of underrepresented groups in our trainee pool, (3) achieving 100% participation of mentors and trainees in formal mentor training, (4) achieving four high-impact publications per trainee, (5) achieve 75% job placement in pharmacology-related careers within two years of degree, (6) continuing to expand our internship opportunities, and (7) increasing the adoption of best practices in graduate admissions. We are committed to training the next generation of pharmacological scientists, building on the strengths of Georgetown’s long track record of success in pharmacology.