Pharmacological Sciences Training Program (PSTP)

项目摘要 乔治敦大学医学中心的药理学培训计划(PSTP)是新的， 跨学科和综合课程，将汇聚一个包容和多样化的博士社区 致力于药理学论文研究的博士研究生。教员 PSTP中的导师在识别细胞信号通路中的药物靶点方面分享了主要的研究优势 用来治疗人类疾病。该项目中的28名导师和11名导师都有很强的 在疾病治疗药物开发方面的指导和研究计划，每年3000万美元 研究经费。参加该项目的学员来自药理学和生理学博士项目， 生物化学、肿瘤生物学和神经科学。学员将为未来在学术界、制药行业的职业生涯做准备 或生物技术行业，或药品监管机构。这项申请要求每年资助六名博士后。 学生，提供催化剂，将四个支线计划结合在一起，并将成为唯一的NIGMS T32，位于 顾先生。学员将在他们研究生院的第二年进入该项目，第二年将得到支持 和第三年，并将在其剩余的学位期间持续参与。实习生参加 药理学、生理/生化原理的综合核心课程 药理学，以及与其研究相关的药理学专业选修课。认识到 药理学的跨学科性质，学生将有更多的机会接触生物信息学， 分子和细胞生物学，以及整合了药理学的生物统计学。我们的课程视野开阔。 从细胞网络到器官功能再到行为和系统医学。培训将提高他们的 了解特定于其学习和研究领域的药物机制，并使他们能够 疾病中新的药物靶点和信号通路。学员和导师都将参加结构化课程 导师培训。在支持期间，所有学员将有两个专门的实习区块：一个部分- 时间上，乔治敦大学将进行为期一学期的实习(例如，法规事务、技术商业化)； 第二块将是暑期在当地一家合作机构(生物技术、政府、基金会)实习。 因此，我们的实习生将在发展自己的职业生涯的同时，获得广泛的职业技能。 研究能力。我们已经制定了计划目标，包括(1)在5.5年内获得95%的学位 (2)在我们的实习生人才库中达到代表不足群体的30%，(3)实现 100%让导师和受训人员参加正式的导师培训，(4)出版了四本影响很大的出版物 每名学员，(5)在获得学位后两年内实现75%的药理学相关职业就业，(6) 继续扩大我们的实习机会，以及(7)更多地采用毕业生的最佳实践 招生。我们致力于培养下一代药理学科学家，在此基础上 乔治敦大学在药理学方面的长期成功记录的优势。

Project Summary The Pharmacological Sciences Training Program (PSTP) at Georgetown University Medical Center is new, interdisciplinary and integrated program that will bring together an inclusive and diverse community of doctoral candidates across Ph.D. disciplines who are dedicated to thesis research in pharmacological science. Faculty mentors in the PSTP share major research strengths in identifying drug targets within cellular signaling pathways to treat human disease. The 28 mentor and 11 preceptor faculty in the program all have a strong history of mentorship and research programs in drug development for disease treatment with >$30 million in annual research funding. Trainees in the program are drawn from Ph.D. programs in Pharmacology & Physiology, Biochemistry, Tumor Biology, and Neuroscience. Trainees will prepare for future careers in academia, pharma or biotechnology industry, or drug regulatory agencies. This application seeks annual funding for six predoctoral students, providing a catalyst to bring together the four feeder programs, and would be the only NIGMS T32 at GU. Trainees will enter the program in their second year of graduate school, will be supported for their second and third years, and will have ongoing participation throughout the remainder of their degree. Trainees take a comprehensive set of core courses in pharmacological sciences, physiological/biochemical principles integral to pharmacology, and specialized electives in pharmacology relevant to their research. Recognizing the interdisciplinary nature of pharmacological sciences, students will have additional exposure to bioinformatics, molecular and cellular biology, and biostatistics that integrate pharmacology. Our courses take a wide view ranging from cellular networks to organ function to behavior and systems medicine. Training will enhance their understanding of drug mechanisms specific to their field of study and research, and enable them to characterize novel drug targets and signaling pathways in disease. Both trainees and mentors will participate in structured mentor training. During the period of support, all trainees will have two dedicated blocks for internships: one part- time, semester-long placement will occur at Georgetown (e.g., regulatory affairs, technology commercialization); the second block will be summer internship at a local partnering institution (biotech, government, foundations). Thus, our trainees will gain broad exposure to transferable skills across career paths while developing their research abilities. We have set program goals to include (1) achieving a 95% degree attainment within 5.5 years of matriculation, (2) achieving 30% representation of underrepresented groups in our trainee pool, (3) achieving 100% participation of mentors and trainees in formal mentor training, (4) achieving four high-impact publications per trainee, (5) achieve 75% job placement in pharmacology-related careers within two years of degree, (6) continuing to expand our internship opportunities, and (7) increasing the adoption of best practices in graduate admissions. We are committed to training the next generation of pharmacological scientists, building on the strengths of Georgetown’s long track record of success in pharmacology.