The Clinical Translational Research Certificate of Added Qualification Program

附加资格项目临床转化研究证书

• 批准号: 10654873
• 负责人: CAROLYN Louise SMITH
• 金额: $ 42.44万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10654873
• 关键词: Qualifying; Translational Research; clinical translation; programs

Project Summary/Abstract. We are requesting support for a new interdisciplinary “Clinical Translational Research Certificate of Added Qualification” (CTR-CAQ) training program for graduate students enrolled in any of the PhD-awarding graduate programs at Baylor College of Medicine (BCM). This program has strong support from BCM leadership, graduate faculty and students. The mission of the rigorous two-year program is to provide students who seek a career focused on the translation of biomedical discoveries into molecular medicine advances, with integrated education in the foundational knowledge and professional skills required to lead effective translational research teams. The rationale for this program builds upon our 14-year experience of successfully integrating translational research training in a single graduate program in Translational Biology and Molecular Medicine (TBMM). A diverse group of TBMM graduates are currently engaged in multiple diverse translational research careers. This success provided the premise that translational research training accessible to all graduate students at BCM is vital to develop a diverse research workforce in all subdisciplines of biomedical science. This need cannot be reliant on physician-scientists alone and must include a diverse cadre of PhD scientists. Internal evaluation of TBMM outcomes and review of national priorities for education and skills development to enhance career preparedness of an increasingly important translational research workforce, form the basis of measurable objectives of the new program. We will combine the best components of the legacy TBMM program with several new innovative strategies for: (a) Recruitment and retention of a diverse cadre of students in the translational workforce; (b) Mentor training, mentor collaboration, and mentorship oversight; (c) Practical skill development and career preparedness for translational research, including training in regulatory knowledge and its practical application in meaningful team-based science, and in leadership; (d) Formal evaluation of overall programmatic effectiveness, individual perceived benefits during the trainee trajectory through the program, and of short- and long-term outcomes upon completion of the program. Thus, the primary objectives of the program are: (1) to prepare students for careers in translational research by combining formative didactic teaching, skill development workshops and experiential learning in clinical research settings with a mentored translational research project deliverable in the form of a capstone project with team-work components; (2) to effectively integrate this program with the training in the primary PhD- training programs; (3) to develop and monitor best mentorship practices; (4) to formally evaluate programmatic and individual outcomes during and after students participate in the CTR-CAQ program. We anticipate that this program will develop a cadre of leaders in translational molecular medicine and team-based research who will remain engaged in a diverse array of academic and non-academic biomedical science careers.

项目摘要/摘要。 我们请求支持新的跨学科“临床转化研究证书” 资格”（CTR-CAQ）培训计划，针对就读于任何博士学位授予研究生的研究生 贝勒医学院 (BCM) 的课程。该计划得到了BCM领导层的大力支持， 研究生教师和学生。这个严格的两年制课程的使命是为那些寻求 职业生涯专注于将生物医学发现转化为分子医学进步，并整合 开展有效转化研究所需的基础知识和专业技能教育 团队。该计划的基本原理建立在我们 14 年成功整合经验的基础上 转化生物学和分子医学单一研究生课程的转化研究培训 （TBMM）。一群多元化的 TBMM 毕业生目前正在从事多种不同的转化研究 职业生涯。这一成功为所有毕业生提供了转化研究培训的前提 BCM 的学生对于在生物医学科学的所有分支领域培养多元化的研究队伍至关重要。 这种需求不能仅仅依赖于医师科学家，而必须包括多元化的博士科学家骨干队伍。 对 TBMM 成果进行内部评估并审查国家教育和技能发展优先事项，以 加强日益重要的转化研究队伍的职业准备，形成基础 新计划的可衡量目标。我们将结合传统 TBMM 的最佳组件 计划，其中包括若干新的创新战略：(a) 招聘和留住多元化的骨干人员 翻译工作者中的学生； (b) 导师培训、导师合作和导师监督； (三) 转化研究的实用技能发展和职业准备，包括监管培训 知识及其在有意义的团队科学和领导力中的实际应用； (d) 正式 评估整体计划有效性、受训者轨迹中的个人感知收益 通过该计划，以及该计划完成后的短期和长期成果。 因此，该计划的主要目标是：（1）通过以下方式为学生从事转化研究职业做好准备： 将形成性教学、技能发展研讨会和临床体验式学习相结合 研究环境，并以顶点项目的形式提供指导性转化研究项目 具有团队合作的成分； （2）将本项目与初级博士生培养有效结合 培训计划； (3) 制定和监督最佳指导实践； (4) 正式评估程序化 以及学生参加 CTR-CAQ 计划期间和之后的个人成果。我们预计这 该计划将培养一批转化分子医学和团队研究领域的领导者，他们将 继续从事各种学术和非学术生物医学科学职业。

项目成果

ClinicalOmicsDB: exploring molecular associations of oncology drug responses in clinical trials.

• DOI: 10.1093/nar/gkad871
• 发表时间: 2024-01-05
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Moon CI;Elizarraras JM;Lei JT;Jia B;Zhang B
• 通讯作者: Zhang B

Engineered Adoptive T-Cell Therapies for Breast Cancer: Current Progress, Challenges, and Potential.

乳腺癌的工程过继 T 细胞疗法：当前进展、挑战和潜力。

• DOI: 10.3390/cancers16010124
• 发表时间: 2023-12-26
• 期刊: CANCERS
• 影响因子: 5.2
• 作者: Chamorro, Diego F.;Somes, Lauren K.;Hoyos, Valentina
• 通讯作者: Hoyos, Valentina

Group B Streptococcus CAMP Factor Does Not Contribute to Interactions with the Vaginal Epithelium and Is Dispensable for Vaginal Colonization in Mice.

• DOI: 10.1128/spectrum.01058-21
• 发表时间: 2021-12-22
• 期刊: Microbiology spectrum
• 影响因子: 3.7
• 作者: Ballard MB;Mercado-Evans V;Marunde MG;Nwanosike H;Zulk J;Patras KA
• 通讯作者: Patras KA

Human Milk Oligosaccharides Reduce Murine Group B Streptococcus Vaginal Colonization with Minimal Impact on the Vaginal Microbiota.

• DOI: 10.1128/msphere.00885-21
• 发表时间: 2022-02-23
• 期刊: mSphere
• 影响因子: 4.8
• 作者: Mejia ME;Ottinger S;Vrbanac A;Babu P;Zulk JJ;Moorshead D;Bode L;Nizet V;Patras KA
• 通讯作者: Patras KA