Development of Psychopathology: From Brain and Behavioral Science to Intervention

项目总结 本申请是关于精神病理学发展的T32培训计划的5年续期： 从大脑和行为到干预。因为精神和药物滥用障碍更有可能 在生命的早期阶段，早期识别风险过程和早期干预至关重要(Insel，2014)。作为田野 已经从行为的重点转向神经发展的重点，这个培训计划也演变成 反映了人脑发育的重要进展。这一跨学科计划的主要目的是 培养出将(1)对神经生物学和心理社会学知识状况做出贡献的科学家 精神病理学发展和维持的潜在机制，以及(2)从 建立预防和改善艾滋病经验型干预措施的基础研究 精神病理学和促进心理健康。该培训计划在以下方面提供个人指导 多学科科学辅以教学活动。为每个人制定了个性化的培训计划 每学期都要重新评估一次。在过去的五年里，我们继续加强对 神经生物学、心理生理学、遗传学和心理社会机制的多学科研究 潜在的精神疾病。为此，我们对我们的核心培训人员进行了一些修改。全部24个 教职员工目前得到资助，其中75%的人至少在一次拨款中担任个人投资机构，其他人担任联合个人投资机构或 调查人员。我们目前三分之二的培训教师积极参与神经科学研究。另一个 我们54%的教职员工进行旨在减少或预防精神问题的干预研究，包括 抑郁、焦虑和药物使用。在过去的十年里，我们所有26名博士后和10名博士后实习生 继续通过学术研究、教学和管理为该领域做出贡献。三个预科博士 继续接受此T32的培训；2名前实习生正在撰写论文；4名正在完成要求的论文 临床实习。剩下的17名前博士前实习生都完成了博士学位；4人从事研究 心理学或医学系的密集教员职位；3正在进行密集的研究 博士后奖学金。剩下的10名前博士后实习生正在做一些与研究相关的工作 包括教学、监督或管理。在10名博士后研究员中，有2名仍在接受培训；8名博士后研究员中有6名 (75%)前博士后积极参与研究密集型教职，所有人都获得了一些 外部资金的种类(例如，K‘s；R01，基金会)。在过去10年中，22%的受训人员来自以下年龄段- 代表少数民族或经济弱势群体；83%是女性。此续期申请 提议每年再次支持4名博士后和2名博士后实习生。未来5年的目标是 继续培训能够发现和转化临床基础知识的独立研究科学家 将神经科学转化为干预措施，以减少精神病理学。

PROJECT SUMMARY This application is for a 5-year renewal of the T32 Training Program in the Development of Psychopathology: From Brain and Behavior to Intervention. Because mental and substance abuse disorders are more likely to arise early in life, early identification of risk processes and early intervention are crucial (Insel, 2014). As the field has been shifting from a behavioral to a neurodevelopmental focus, this training program also has evolved to reflect important advances in human brain development. The major thrust of this interdisciplinary program is to produce scientists who will (1) contribute to the state of knowledge about neurobiological and psychosocial mechanisms underlying the development and maintenance of psychopathology, and (2) translate findings from basic research to the construction of empirically-based interventions for the prevention and amelioration of psychopathology and for the promotion of mental health. This training program provides individual mentoring in multidisciplinary science complemented by didactic activities. A personalized training plan is developed for each fellow and re-evaluated each semester. In the last five years, we have continued to increase training on multidisciplinary research on neurobiological, psychophysiological, genetic, and psychosocial mechanisms underlying psychiatric illness. To this end, we have made some changes to our core, training faculty. All 24 faculty are currently funded, with 75% as PIs on at least one grant, and the others serving as co-PIs or investigators. Two-thirds of our current training faculty are actively involved in neuroscience research. Another 54% of our faculty conduct intervention studies aimed at reducing or preventing psychiatric problems including depression, anxiety, and substance use. In the last decade, all of our 26 pre- and 10 post-doctoral trainees have continued to contribute to the field through scholarly research, teaching, and administration. Three predocs remain in training on this T32; 2 former trainees are working on their dissertations; 4 are doing their required clinical internship. All 17 remaining former predoc trainees have completed their PhDs; 4 are engaged in research intensive faculty positions in academic departments of psychology or medicine; 3 are doing research intensive postdoctoral fellowships. The remaining 10 former predoc trainees are doing some research related work including teaching, supervision, or administration. Of the 10 postdoctoral fellows, 2 are still in training; 6 of the 8 (75%) former postdocs are actively involved in research intensive faculty positions and all have received some kind of external funding (e.g., K’s; R01, Foundations). In the past 10 years, 22% of all trainees were from under- represented ethnic minority or economically disadvantaged groups; 83% are female. This renewal application proposes to again support 4 predoctoral and 2 postdoctoral trainees annually. Goals for the next 5 years are to continue to train independent research scientists who can discover and translate basic knowledge from clinical neuroscience into interventions for reducing psychopathology.