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High-throughput screening to identify inhibitors of breast-to-brain metastasis

High-throughput screening to identify inhibitors of breast-to-brain metastasis
高通量筛选以确定乳腺至脑转移的抑制剂
批准号：
10688955
负责人：
Mark Henderson
金额：
$25.96万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10688955
关键词：
Biological AssayBiologyBrainBreastCellsCollaborationsDiseaseExtramural ActivitiesGoalsInformaticsLife ExpectancyMetastatic malignant neoplasm to brainModelingPharmaceutical ChemistryPhenotypeProcessQuality of lifeResearchResearch PersonnelSynthesis ChemistryTranslationsUnited States National Institutes of HealthValidationWomanWorkassay developmentbasebrain celldesigndrug developmentdrug discoveryhigh throughput screeningin vitro Modelinhibitorinterestlead optimizationmalignant breast neoplasmnew technologynovelscreeningsmall moleculesmall molecule therapeuticstherapeutic candidatetherapeutic developmenttool

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中文摘要
翻译
该项目旨在识别和开发针对乳腺到脑转移的小分子。15-30%的IV期乳腺癌女性发生脑转移，对预期寿命和生活质量产生负面影响。靶向这些转移性细胞的小分子化学治疗剂是令人感兴趣的，然而，存在有限数量的可用于鉴定和开发此类治疗候选物的体外模型。 在此期间，该团队专注于设计，优化和实施使用乳腺至脑转移细胞的高通量筛选检测。 此外，该团队开发了一种最大化试验，以鉴定能够协同杀死脑转移细胞的小分子组合。
英文摘要
This project seeks to identify and develop small molecules that target breast-to-brain metastasis. 15-30% of women with stage IV breast cancer develop brain metastases, which negatively impacts life expectancy and quality of life. Small molecule chemotherapeutics that target these metastatic cells are of interest, however, there are a limited number of in vitro models available to identify and develop such therapeutic candidates. During this period, the team focused on design, optimization, and implementation of a high-throughput screening amenable assay using breast-to-brain metastatic cells. Additionally, the team developed a maxtrix assay to identify small molecule combinations that would synergistically kill the brain-metastatic cells.
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国内基金
海外基金
Journal of Integrative Plant Biology
  • 批准号：
    31024801
  • 项目类别：
    专项基金项目
  • 资助金额：
    24.0万元
  • 批准年份：
    2010
  • 负责人：
    贺萍
  • 依托单位：
    中国科学院植物研究所