High-throughput screening to identify inhibitors of breast-to-brain metastasis

该项目旨在识别和开发针对乳腺到脑转移的小分子。15-30%的四期乳腺癌女性会发生脑转移，这会对预期寿命和生活质量产生负面影响。靶向这些转移性细胞的小分子化疗药物引起了人们的兴趣，然而，用于鉴定和开发此类治疗候选药物的体外模型数量有限。

This project seeks to identify and develop small molecules that target breast-to-brain metastasis. 15-30% of women with stage IV breast cancer develop brain metastases, which negatively impacts life expectancy and quality of life. Small molecule chemotherapeutics that target these metastatic cells are of interest, however, there are a limited number of in vitro models available to identify and develop such therapeutic candidates. This collaborative project will pursue high-throughput screening, using novel in vitro models, to identify small molecules that target metastatic breast-to-brain cells. During this period, the team focused on design, optimization, and implementation of a high-throughput screening amenable assay using breast-to-brain metastatic cells.