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High-throughput screening to identify inhibitors of breast-to-brain metastasis

High-throughput screening to identify inhibitors of breast-to-brain metastasis
高通量筛选以确定乳腺至脑转移的抑制剂
批准号：
10916047
负责人：
Mark Henderson
金额：
$24.08万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10916047
关键词：
Automobile DrivingBasic ScienceBiological AssayBrainBreastBreast Epithelial CellsCellsDrug KineticsHealthHumanHuman GenomeMetastatic malignant neoplasm to brainNational Center for Advancing Translational SciencesRare DiseasesResearchRouteToxic effectTranslationsbrain celldrug candidateefficacy studyhigh throughput screeningimprovedin vivoinhibitorinterestnovelpharmacologicprogramssmall moleculetool

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英文摘要
During this period, the collaborative team performed high-throughput screening to identify small molecules that selectively kill breast-to-brain metastatic cells relative to normal breast epithelial cells. Several compounds of interest emerged, which were advanced to pharmacokinetic studies to characterize brain exposure and select route of administration. In vivo efficacy studies are currently underway. Additionally, the team developed a matrix assay to identify small molecule combinations which display synergistic toxicity against brain-metastatic cells. Several combination screens have been performed and the team is assessing options for advancing to efficacy studies.
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