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New approaches for facilitating transcytosis of biologically active molecules

New approaches for facilitating transcytosis of biologically active molecules
促进生物活性分子转胞吞作用的新方法
批准号：
10916060
负责人：
Mark Henderson
金额：
$12.58万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10916060
关键词：
AntibodiesAutomobile DrivingBasic ScienceBlood - brain barrier anatomyBrainChemistryEncapsulatedEndotheliumFc domainHealthHumanHuman GenomeLigandsMethodsNational Center for Advancing Translational SciencesPhospholipidsPolysaccharidesRare DiseasesResearchSystemTranslationsVesicledrug candidateexosomeimprovednovel strategiespharmacologicprogramstooltranscytosis

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During this period, the collaborative team developed methods to produce lipidic vesicles mimicking the composition of exosomes. These vesicles were used to encapsulate small fluorescent molecules, and incorporation of functionalized phospholipids within these vesicles enabled the use of click chemistry. This approach will allow the attachment of ligands able to promote transcytosis across the blood-brain barrier. The team is currently validating methods to trim and modify the glycan of the Fc domain of antibodies to facilitate click chemistry, with the aim of clicking these antibodies to lipidic vesicles.
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