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AMPK synthetic activators

AMPK synthetic activators
AMPK 合成激活剂
批准号：
10916050
负责人：
Mark Henderson
金额：
$24.08万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10916050
关键词：
5&apos-AMP-activated protein kinaseAdenosine MonophosphateAutophagocytosisBiological AssayCellsCholesterolDataDiseaseHomeostasisLysosomal Storage DiseasesMass Spectrum AnalysisMeasuresMetabolismModelingNational Center for Advancing Translational SciencesPathway interactionsPharmaceutical ChemistryProtein KinaseScientistStressTestingWorkefficacy studyimprovedin vivomethyl-beta-cyclodextrinnovelresponsesmall molecule

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英文摘要
During this period the collaborative team has worked to characterize a number of small molecule hits previously found to activate 5' adenosine monophosphate-activated protein kinase (AMPK). The team has optimized select chemotypes via medicinal chemistry efforts and implemented a novel high-throughput mass spectrometry assay to measure cholesterol to test activity of the compounds. Top actives were tested in the context of Niemann Pick C, a lysosomal storage disease characterized by cholesterol accumulation. The team is utilizing mass spectrometry data to nominate a small number of compounds for additional cell based characterization, followed by in vivo efficacy studies.
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