COMMUNITY DEVELOPMENT OF THE CELL-CENTERED DATABASE

描述(由申请人提供)：本提案概述了继续开发和维护OpenCCDB软件套件的计划，该软件套件是一套基于网络的管理、可视化和注释大型多维光学和电子显微镜成像数据集的工具。现代分析和基于分子的生物医学研究越来越多地利用以细胞为中心的多尺度和多模式成像来洞察细胞和组织的分子结构的空间受限相互作用。OpenCCDB是在细胞中心数据库(CCDB0项目)的支持下开发的，CCDB0项目是一个共享细胞和组织显微成像数据的在线存储库和平台。CCDB项目基于开发联合访问超大型3D成像数据集的解决方案，这些数据集由不同的仪器产生，并跨不同的技术平台进行维护。CCDB模型建立在灵活且可扩展的数据存储之上，这些数据存储可以在全球范围内部署，但可以通过CCDB的中央元数据系统进行访问，并通过神经科学信息框架(http://neuinfo.org).)等数据联邦进行链接在上一次资助期间，美国细胞生物学学会在ARRA基金的支持下推出了自己的数据库。细胞：图像库目前包含37,000个来自光学和电子显微镜的示例性成像数据集，所有这些数据集都可以通过一个优雅的以细胞为中心的用户界面获得。为了为研究和教育提供更统一和可持续的资源，ASCB理事会和执行委员会于2011年投票决定与UCSD的团队合作，将他们的策展和界面设计专业知识和成就与UCSD的数据库和软件开发专业知识和成就结合起来。在这样做的过程中，ASCB将其用户门户环境“细胞：图像库”的开发和未来可持续性的控制权移交给了加州大学圣迭戈分校的CCDB团队。这个新的联盟立即应用了CCDB的开源软件框架OpenCCDB来扩展Cell的功能：一个图像库系统，增加了上传和探索海量数据集的新功能，促进了数据共享，并将其底层数据库与CCDB完全联合。由此产生的集成环境为科学界提供了比以前更全面的解决方案，以推动以细胞为中心的生物医学研究和教育。在这项提案中，我们概述了在“细胞：图像库”的背景下开发和部署更多个性化数据管理和注释工具的目标，将社交网站的能力和工具与基于网络的管理、共享、注释和联合超大型显微成像数据集的专门工具结合起来。 公共卫生相关性：这份续订申请概述了加强和进一步开发Open CCDB软件平台代码库的计划，以支持通过合并细胞图像库和细胞中心数据库建立的新的以细胞为中心的联合显微镜资源。

DESCRIPTION (provided by applicant): This proposal outlines plans for continued development and maintenance of the OpenCCDB software suite, a set of tools for web-based management, visualization and annotation of large multidimensional light and electron microscopic imaging data sets. Modern analytical and molecularly-based biomedical investigations increasingly draw upon multiscale and multimodal cell-centered imaging to gain insight into spatially constrained interactions of molecular machinery of cells and tissues. The OpenCCDB was developed under the auspices of the Cell Centered Database (CCDB0 project, an on-line repository and platform for sharing microscopic imaging data of cells and tissues. The CCDB project was predicated on developing solutions for federating access to very large 3D imaging data sets, produced by diverse instrumentations and maintained across diverse technological platforms. The CCDB model is built on flexible and expandable data stores that can be fielded globally but accessed through CCDB's central metadata system and linked through data federations like the Neuroscience Information Framework (http://neuinfo.org). During the last funding period, the American Society for Cell Biology launched its own data repository, with support from ARRA funding. The Cell: An Image Library currently contains > 37,000 exemplary imaging data sets from light and electron microscopy, all available through an elegant cell-centered user interface. To provide a more unified and sustainable resource for research and education, the ASCB Council and Executive Committee voted in 2011 to partner their effort with the group at UCSD, combining their curatorial and interface design expertise and accomplishments with UCSD's database and software development expertise and accomplishments. In so doing, ASCB transitioned control of the development and future sustainability of their user portal environment, "The Cell:An Image Library" to the CCDB team at UCSD. Immediately, this new alliance applied CCDB's open source software framework, OpenCCDB, to the task of extending the functionality of The Cell: An Image Library system, adding new capability to upload and explore massive datasets, facilitate data sharing, and completely federate its underlying database with the CCDB. The resultant integrated environment offers the scientific community a more comprehensive solution to propel cell-centric biomedical research and education than that offered previously. In this proposal, we outline aims to develop and deploy additional personalized data management and annotation tools within the context of The Cell: An Image Library, by combining the power and tools of a social networking site with specialized tools for web-based management, sharing, annotation and federation of very large microscopic imaging data sets. PUBLIC HEALTH RELEVANCE: This renewal application outlines plans to harden and further develop the code base of the Open CCDB software platform in support of the new joint cell-centered microscopy resource established through the merging of the Cell Image Library and the Cell Centered Database.