Rapid, Multiplexed, Idealized Antiepileptic Drug Monitoring

项目摘要 治疗药物监测（TDM）是临床药理学和临床化学的一个分支，其重点是 测量药物浓度，通常在血清或血浆中。量化体内药物浓度 使得临床医生能够基于建立和优化针对个体患者的处方药物剂量， 了解药物代谢的相关药代动力学和药效学关系， 在不同的病人之间会有很大的差异。因此，TDM对于个性化患者治疗计划至关重要， 使精准医疗能够改善患者护理和结果。然而，目前没有简单的， 快速（<15分钟），易于使用，价格低廉的设备，可以准确地测量药物水平，从给定的 sample.为了应对这一技术差距，在此计划期间，电子生物科学（EBS），在合作 拥有一个高度跨学科的现场专家团队，将开发一个真正独特的，使能的，最先进的TDM 技术，克服了已知的目标表征问题，困扰了 生物传感器/免疫分析领域多年来。在这个项目中，EBS将特别关注抗癫痫药物 监测是TDM的一个子集，沿着， 一旦被开发，所提出的技术具有巨大的商业潜力。然而应当 注意到在该计划期间开发的技术和相关方法将转移到 其他TDM应用，包括但不限于抗生素、免疫抑制剂、抗精神病药等。

Project Summary Therapeutic drug monitoring (TDM) is a branch of clinical pharmacology and clinical chemistry focused on the measurement of drug concentrations, typically in serum or plasma. Quantifying a drug concentration in the body enables a clinician to tailor/optimize prescribed drug dosages to the individual patient, based on establishing and understanding the associated pharmacokinetic and pharmacodynamic relationships of drug metabolism, which can vary drastically between patients. Thus, TDM is critical toward personalizing patient treatment plans and enabling precision medicine for improved patient care and outcomes. However, there is currently no simple, rapid (<15 min), easy-to-use, and inexpensive device that can accurately measure drug levels from a given sample. In response to this technology gap, during this program, Electronic BioSciences (EBS), in collaboration with a highly interdisciplinary team of field experts, will develop a truly unique, enabling, and state-of-the-art TDM technology that overcomes the known target characterization problems that have plagued the biosensor/immunoassay field for years. During this project, EBS will be focusing specifically on antiepileptic drug monitoring, a subset of TDM that has an urgent and pressing need for improved characterization methods, along with a significant commercial potential for the proposed technology once it is developed. However, it should be noted that the technology and associated methodology developed during this program will be transferable to other TDM applications, including but not limited to antibiotics, immunosuppressants, antipsychotics, etc.