Upgrade of the NMRFAM 750 MHz NMR Spectrometer

描述（由申请人提供）：本提案针对恢复法案有限竞争，高端仪器资助计划（S10）计划公告（PA）编号：PAR-09-118。申请资金用于升级位于威斯康星大学麦迪逊分校麦迪逊国家磁共振设施（NMRFAM）的布鲁克750 MHz核磁共振光谱仪。对于原始系统成本的一小部分，这款老化的光谱仪可以恢复到当前的规格，并使其与用户要求的当前脉冲程序和自动化兼容。该请求将支持低温恒温器的重建，该低温恒温器装有超导螺线管（更新o形环和密封），用于泵送系统的新控制器，使系统保持在现场（以取代失效且不再受供应商支持的单元），一个新的控制台，将提供更高的灵敏度，更灵活的脉冲编程，双接收器，改进的可变温度操作。以及为支撑低温探头的低温平台改造压缩机。这种核磁共振光谱仪被美国国立卫生研究院资助的威斯康星大学麦迪逊分校和其他机构的研究小组大量使用。在NMRFAM的布鲁克光谱仪中，750 MHz具有最高的场，是使用最多的核磁共振光谱仪。它受到用户的青睐，用户对这个品牌比较放心。用户群有NIH资助的各种生物医学领域的研究项目。

DESCRIPTION (provided by applicant): This proposal is directed to the Recovery Act Limited Competition, High-End Instrumentation Grant Program (S10) Program Announcement (PA) Number: PAR-09-118. Funds are requested to upgrade the Bruker 750 MHz NMR spectrometer located in the National Magnetic Resonance Facility at Madison (NMRFAM), University of Wisconsin-Madison. For a fraction of the cost of the original system, this aging spectrometer can be brought back to current specifications and made to be compatible with the current pulse programs and automation demanded by users. This request will support the rebuilding of the cryostat that houses the superconducting solenoid (renewed O-rings and seals), a new controller for the pumping system that keeps the system at field (to replace a unit that is failing and is no longer supported by the vendor), a new console that will provide improved sensitivity, more flexible pulse programming, dual receivers, improved variable temperature operation, and rebuilding of the compressor for the cryoplatform that supports the cryogenic probe. This NMR spectrometer is heavily used by NIH-funded research groups at the University of Wisconsin-Madison and other institutions. Of the Bruker spectrometers at NMRFAM, the 750 MHz has the highest field and is the most heavily used NMR spectrometer. It is favored by users who are more comfortable with this brand. The user base has NIH funded research projects a variety of areas of biomedical interest. PUBLIC HEALTHE RELEVANCE: Funds are requested to upgrade a key NMR spectrometer (Bruker 750 MHz) in the National Magnetic Resonance Facility at Madison to correct serious problems with its reliable operation and to bring it up to current standards of sensitivity, pulse programming flexibility, and automation. Modernization of the instrument will fulfill the demands from users on and off campus for the NMR data collection capability needed to carry out their NIH-funded biomedical research projects.