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Redox homeostasis in cancer and cardiovascular diseases

Redox homeostasis in cancer and cardiovascular diseases
癌症和心血管疾病中的氧化还原稳态
批准号：
10253837
负责人：
PAUL M. HWANG
金额：
$96.65万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10253837
关键词：
AffectBiologyCardiomyopathiesCardiovascular DiseasesCardiovascular PhysiologyCell SurvivalCellsCellular StressDiagnosisDiseaseDoxorubicinEnergy MetabolismGenerationsGeneticHomeostasisMalignant NeoplasmsMethodsMitochondriaMitochondrial DNAOxidation-ReductionOxidative StressOxygenPathogenesisPreventionReactive Oxygen Specieschemotherapymitochondrial dysfunctionoxidative DNA damagepreventtumorigenesis

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中文摘要
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英文摘要
Our previous studies have suggested that mitochondrial dysfunction causes oxidative DNA damage and contributes to tumorigenesis. A major contributing factor to oxidative stress is ambient oxygen which is the essential substrate for reactive oxygen species generation. Environmental and genetic methods will be used to modulate redox homeostasis and to determine their effect on energy metabolism, tumorigenesis, and cardiovascular function. We are also examining the adaptive mechanisms by which cells can survive under oxidative or other cellular stress conditions. We have recently demonstrated the importance of maintaining mtDNA to prevent doxorubicin-induced cardiomyopathy and are investigating new strategies for diagnosis and prevention.
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会议论文
Genetic insights into mitochondrial function, cancer and cardiovascular diseases
Effects of redox homeostasis on cancer and cardiovascular diseases
Redox homeostasis in cancer and cardiovascular diseases
Genetic insights into cardiovascular function and disease
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海外基金
Journal of Integrative Plant Biology
  • 批准号：
    31024801
  • 项目类别：
    专项基金项目
  • 资助金额：
    24.0万元
  • 批准年份：
    2010
  • 负责人：
    贺萍
  • 依托单位：
    中国科学院植物研究所