Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children

CHARGE 研究儿童的青春期前和青春期后期随访

• 批准号: 10240314
• 负责人: Deborah Hall Bennett
• 金额: $ 392.21万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10240314
• 关键词: Adolescence; Adolescent; Adrenal Glands; Adrenal hormone preparation; Age; Air Pollutants; Air Pollution; Anxiety; Area; Attention deficit hyperactivity disorder; Attentional deficit; Behavior Disorders; Behavioral Symptoms; Blood; Buffers; Characteristics; Chemicals; Child; Child Health; Childhood; Childhood Autism Risks from Genetics and the Environment; Cognitive; Collaborations; Collection; Crime; DNA; DNA Methylation; Data; Development; Developmental Delay Disorders; Diagnosis; Diagnostic; Elements; Enrollment; Environment; Epigenetic Process; Family; General Population; Genetic Predisposition to Disease; Goals; Green space; Heterogeneity; Hyperactivity; Immune; Infrastructure; Institutional Review Boards; Intervention; Investigation; Leadership; Life; Life Cycle Stages; Light; Manuals; Measures; Mediation; Mediator of activation protein; Mental Depression; Mental Health; Metals; Methods; Modeling; Monitor; Mood Disorders; Neighborhoods; Newborn Infant; Nutrient; Nutritional; Outcome; Parents; Participant; Pesticides; Pharmaceutical Preparations; Phase; Poverty; Predisposition; Preparation; Procedures; Prospective Studies; Protocols documentation; Psychopathology; Recontacts; Resources; Risk; Saliva; Sampling; Severities; Sex Differences; Site; Specimen; Spottings; Steroids; Symptoms; System; Testing; United States National Institutes of Health; Work; age group; aged; anxiety symptoms; autism spectrum disorder; autistic children; cognitive performance; cohesion; cohort; comorbidity; course development; depressive symptoms; disability; environmental chemical; follow-up; grandparent; improved; instrument; interest; intergenerational; method development; mother nutrition; neurodevelopment; novel; nutrition; phthalates; preadolescence; prenatal exposure; programs; prospective; protocol development; public health priorities; public health relevance; recruit; repository; resilience; risk variant; sex; skills; social; social factors; sociodemographics; stressor; treatment services

The proposed UC Davis ECHO ReCHARGE Study will follow a cohort of children last seen at ages 2-5 years (‘baseline’) to determine environmental chemical and non-chemical stressors and resiliency factors that are associated with neurodevelopmental outcomes at ages 8-12 years (pre-adolescent) and 15-19 years (mid- to late adolescence). This project leverages the resources of the CHARGE (Childhood Autism Risks from Genes and Environment) Study, which, since 2003, has been enrolling three groups aged 2-5 years: children with autism spectrum disorder (ASD), children with other developmental delays (DD) and children from the general population with typical development (TD). These three groups, the ReCHARGE cohort, will be examined for the following outcomes of interest: attention deficit or hyperactivity symptoms; changes in cognitive or adaptive function; changes in severity or diagnosis; and symptoms of anxiety or depression. Pilot testing will take place in the UG3 phase, and in the UH3 phase, all will be examined either in pre-adolescence or mid- to late adolescence. The primary exposures of interest are pesticides, metals, air pollution, phthalates, nutrients, neighborhood characteristics, and family factors. Additionally, three mechanistic studies are proposed: an investigation of intergenerational epigenetic profiles; method development for metals analysis in dried blood spots; and sex specific associations of adrenal hormones with depressive symptoms. Approximately 1400 families are eligible for ReCHARGE, providing a robust sample for examination of main effects, interaction and mediation analyses. As part of the ECHO consortium, the ReCHARGE team will participate in the synthetic cohort combining children from multiple sites, and the cluster of studies focused on neurodevelopment in harmonizing protocols for the prospective UH3 phase and in seeking to analyze retrospective samples and data collaboratively, where feasible. During the UG3 phase, the ReCHARGE team will develop protocols, pilot test methods for recontacting and recruiting, for epigenetics in saliva vs. blood, and for implementation of the adrenal hormone study, including ways to increase compliance. Unique features of ReCHARGE include the contribution to understanding life course development in children with two different types of disabilities, and a novel model of adrenal hormone relationships with sex-specific affective disorders.

拟议的加州大学戴维斯分校 ECHO ReCHARGE 研究将跟踪一组最后一次见到的儿童年龄为 2-5 岁 年（“基线”）来确定环境化学和非化学压力源和弹性 与 8-12 岁（青春期前）神经发育结果相关的因素 15-19岁（青春期中后期）。该项目利用了 CHARGE 的资源 （基因和环境造成的儿童自闭症风险）研究，自 2003 年以来一直在招募 2-5岁的三组：患有自闭症谱系障碍（ASD）的儿童，患有其他疾病的儿童 发育迟缓 (DD) 和一般人群中具有典型发育 (TD) 的儿童。 ReCHARGE 队列这三个组将接受以下感兴趣的结果检查： 注意力缺陷或多动症状；认知或适应功能的变化；的变化 严重程度或诊断；以及焦虑或抑郁的症状。试点测试将在 UG3期、UH3期，都在青春期前或中后期进行检查 青春期。主要关注的暴露是农药、金属、空气污染、邻苯二甲酸盐、 营养素、邻里特征和家庭因素。 此外，还提出了三项机制研究：代际调查 表观遗传特征；干血斑中金属分析的方法开发；和特定性别 肾上腺激素与抑郁症状的关联。大约1400个家庭有资格 为 ReCHARGE 提供可靠的样本来检查主效应、相互作用和中介作用 分析。作为 ECHO 联盟的一部分，ReCHARGE 团队将参与合成 队列结合了来自多个地点的儿童，并且该组研究集中于 协调预期 UH3 阶段的协议并寻求分析的神经发育 在可行的情况下，协作回顾性样本和数据。在 UG3 阶段，ReCHARGE 团队将开发协议，用于重新接触和招募的试点测试方法，用于表观遗传学 唾液与血液，以及实施肾上腺激素研究，包括增加的方法 遵守。 ReCHARGE 的独特之处包括有助于理解生命历程 患有两种不同类型残疾的儿童的发育，以及一种新颖的肾上腺模型 激素与性别特异性情感障碍的关系。