Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children

CHARGE 研究儿童的青春期前和青春期后期随访

• 批准号: 10675376
• 负责人: Deborah Hall Bennett
• 金额: $ 6.65万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10675376
• 关键词: Adolescence; Adolescent; Adrenal Glands; Adrenal hormone preparation; Age; Air Pollutants; Air Pollution; Anxiety; Area; Attention deficit hyperactivity disorder; Attentional deficit; Behavior Disorders; Behavioral Symptoms; Blood; Buffers; Characteristics; Chemicals; Child; Child Health; Childhood; Childhood Autism Risks from Genetics and the Environment; Cognitive; Collaborations; Collection; Crime; DNA; DNA Methylation; Data; Development; Developmental Delay Disorders; Diagnosis; Diagnostic; Elements; Enrollment; Environment; Epigenetic Process; Family; General Population; Genetic Predisposition to Disease; Goals; Green space; Heterogeneity; Hyperactivity; Immune; Infrastructure; Institutional Review Boards; Intervention; Investigation; Leadership; Life; Life Cycle Stages; Light; Manuals; Measures; Mediation; Mediator of activation protein; Mental Depression; Mental Health; Metals; Methods; Modeling; Monitor; Mood Disorders; Neighborhoods; Newborn Infant; Nutrient; Nutritional; Outcome; Parents; Participant; Pesticides; Pharmaceutical Preparations; Phase; Poverty; Predisposition; Preparation; Procedures; Prospective Studies; Protocols documentation; Psychopathology; Recontacts; Resources; Risk; Saliva; Sampling; Severities; Sex Differences; Site; Specimen; Spottings; Steroids; Symptoms; System; Testing; United States National Institutes of Health; Work; age group; aged; anxiety symptoms; autism spectrum disorder; autistic children; cognitive performance; cohesion; cohort; comorbidity; course development; depressive symptoms; disability; environmental chemical; follow-up; grandparent; improved; instrument; interest; intergenerational; method development; mother nutrition; neurodevelopment; novel; nutrition; phthalates; pilot test; preadolescence; prenatal exposure; programs; prospective; protocol development; public health priorities; public health relevance; recruit; repository; resilience; risk variant; sex; skills; social; social factors; sociodemographics; stressor; treatment services

The proposed UC Davis ECHO ReCHARGE Study will follow a cohort of children last seen at ages 2-5 years (‘baseline’) to determine environmental chemical and non-chemical stressors and resiliency factors that are associated with neurodevelopmental outcomes at ages 8-12 years (pre-adolescent) and 15-19 years (mid- to late adolescence). This project leverages the resources of the CHARGE (Childhood Autism Risks from Genes and Environment) Study, which, since 2003, has been enrolling three groups aged 2-5 years: children with autism spectrum disorder (ASD), children with other developmental delays (DD) and children from the general population with typical development (TD). These three groups, the ReCHARGE cohort, will be examined for the following outcomes of interest: attention deficit or hyperactivity symptoms; changes in cognitive or adaptive function; changes in severity or diagnosis; and symptoms of anxiety or depression. Pilot testing will take place in the UG3 phase, and in the UH3 phase, all will be examined either in pre-adolescence or mid- to late adolescence. The primary exposures of interest are pesticides, metals, air pollution, phthalates, nutrients, neighborhood characteristics, and family factors. Additionally, three mechanistic studies are proposed: an investigation of intergenerational epigenetic profiles; method development for metals analysis in dried blood spots; and sex specific associations of adrenal hormones with depressive symptoms. Approximately 1400 families are eligible for ReCHARGE, providing a robust sample for examination of main effects, interaction and mediation analyses. As part of the ECHO consortium, the ReCHARGE team will participate in the synthetic cohort combining children from multiple sites, and the cluster of studies focused on neurodevelopment in harmonizing protocols for the prospective UH3 phase and in seeking to analyze retrospective samples and data collaboratively, where feasible. During the UG3 phase, the ReCHARGE team will develop protocols, pilot test methods for recontacting and recruiting, for epigenetics in saliva vs. blood, and for implementation of the adrenal hormone study, including ways to increase compliance. Unique features of ReCHARGE include the contribution to understanding life course development in children with two different types of disabilities, and a novel model of adrenal hormone relationships with sex-specific affective disorders.

拟议的UC Davis Echo补给研究将跟随一群2-5岁的儿童队列 确定环境化学和非化学应力和弹性的年（“基线”） 与8-12岁的神经发育结局相关的因素（前青春期前） 和15 - 19年（青春期晚到晚期）。该项目利用收费的资源 （基因和环境的儿童自闭症风险）研究，自2003年以来一直在注册 三组2-5岁：自闭症谱系障碍儿童（ASD），其他患有其他儿童 发育延迟（DD）和典型发展（TD）的一般人群的儿童。 这三个小组将检查以下感兴趣的结果： 注意缺陷或多动症症状；认知或自适应功能的变化；变更 严重性或诊断；和动画或抑郁的症状。试点测试将在 UG3相，在UH3阶段，将在青春期或后期进行检查 青少年。感兴趣的主要暴露是农药，金属，空气污染，邻苯二甲酸盐， 营养，邻里特征和家庭因素。 此外，提出了三项机械研究：代际的投资 表观遗传谱；干燥血液斑的金属分析的方法开发；和特定于性别 肾上腺激素与抑郁症状的关联。大约有1400个家庭有资格 用于补给，提供可靠的样本以检查主要影响，相互作用和调解 分析。作为回声财团的一部分，充值团队将参加合成 队列将来自多个地点的儿童结合在一起，研究集中的集中 为前瞻性UH3阶段协调协议的神经发育，并试图分析 可行的回顾样本和数据协作。在UG3阶段，充电 团队将开发协议，进行重新连接和招聘的试验测试方法，用于表观遗传学 唾液与血液，以及实施肾上腺犬研究，包括增加的方法 遵守。充电的独特功能包括对了解生活课程的贡献 患有两种不同类型疾病的儿童的发展和一种新型肾上腺模型 与性别特异性情感障碍的关系。