Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children - Diversity Supplement

CHARGE 研究儿童的青春期前和青春期后期随访 - 多样性补充

• 批准号: 10412853
• 负责人: Deborah Hall Bennett
• 金额: $ 6.65万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10412853
• 关键词: Adolescence; Adolescent; Adrenal hormone preparation; Age; Air Pollution; Attention deficit hyperactivity disorder; Attentional deficit; Blood; Characteristics; Chemicals; Child; Child Health; Childhood; Cognitive; Data; Development; Developmental Delay Disorders; Diagnosis; Diagnostic; Enrollment; Environment; Epigenetic Process; Family; General Population; Hyperactivity; Intervention; Investigation; Life Cycle Stages; Light; Mediation; Mental Depression; Metals; Methods; Modeling; Mood Disorders; Neighborhoods; Nutrient; Outcome; Pesticides; Phase; Protocols documentation; Recontacts; Resources; Saliva; Sampling; Severities; Site; Spottings; Symptoms; Testing; age group; anxiety symptoms; autism spectrum disorder; autistic children; cognitive performance; cohort; course development; depressive symptoms; disability; environmental chemical; follow-up; improved; interest; intergenerational; method development; neurodevelopment; novel; parent grant; phthalates; preadolescence; prospective; public health priorities; recruit; resilience; risk variant; sex; stressor

Abstract – Parent Grant The proposed UC Davis ECHO ReCHARGE Study will follow a cohort of children last seen at ages 2-5 years (`baseline') to determine environmental chemical and non-chemical stressors and resiliency factors that are associated with neurodevelopmental outcomes at ages 8-12 years (pre-adolescent) and 15-19 years (mid- to late adolescence). This project leverages the resources of the CHARGE (Childhood Autism Risks from Genes and Environment) Study, which, since 2003, has been enrolling three groups aged 2-5 years: children with autism spectrum disorder (ASD), children with other developmental delays (DD) and children from the general population with typical development (TD). These three groups, the ReCHARGE cohort, will be examined for the following outcomes of interest: attention deficit or hyperactivity symptoms; changes in cognitive or adaptive function; changes in severity or diagnosis; and symptoms of anxiety or depression. Pilot testing will take place in the UG3 phase, and in the UH3 phase, all will be examined either in pre-adolescence or mid- to late adolescence. The primary exposures of interest are pesticides, metals, air pollution, phthalates, nutrients, neighborhood characteristics, and family factors. Additionally, three mechanistic studies are proposed: an investigation of intergenerational epigenetic profiles; method development for metals analysis in dried blood spots; and sex specific associations of adrenal hormones with depressive symptoms. Approximately 1400 families are eligible for ReCHARGE, providing a robust sample for examination of main effects, interaction and mediation analyses. As part of the ECHO consortium, the ReCHARGE team will participate in the synthetic cohort combining children from multiple sites, and the cluster of studies focused on neurodevelopment in harmonizing protocols for the prospective UH3 phase and in seeking to analyze retrospective samples and data collaboratively, where feasible. During the UG3 phase, the ReCHARGE team will develop protocols, pilot test methods for recontacting and recruiting, for epigenetics in saliva vs. blood, and for implementation of the adrenal hormone study, including ways to increase compliance. Unique features of ReCHARGE include the contribution to understanding life course development in children with two different types of disabilities, and a novel model of adrenal hormone relationships with sex-specific affective disorders.

抽象父级授予 加州大学戴维斯分校拟议的回声充电研究将跟踪2-5岁最后一次出现的儿童 (“基线”)确定符合以下条件的环境化学和非化学应激源和复原力因素 与8-12岁(青春期前)和15-19岁(中期至19岁)的神经发育结果有关 青春期后期)。这个项目利用了指控的资源(儿童自闭症风险来自基因 和环境)研究，自2003年以来，已经招募了三组2-5岁的儿童：患有 自闭症谱系障碍(ASD)、其他发育迟缓儿童(DD)和一般儿童 典型发展人口(TD)。这三组人，即充电队列，将接受检查 感兴趣的以下结果：注意力缺陷或多动症状；认知或适应能力的变化 功能；严重程度或诊断的变化；焦虑或抑郁症状。将进行试运行测试 在UG3阶段和UH3阶段，所有人都将在青春期前或中晚期接受检查 青春期。关注的主要接触是杀虫剂、金属、空气污染、邻苯二甲酸盐、营养素、 社区特点、家庭因素等。此外，还提出了三个机理研究：一个 代际表观遗传图谱的研究.干血中金属分析方法的发展 斑点；肾上腺激素与抑郁症状的性别相关。大约1400人 家庭有资格获得充值，为检验主要影响、相互作用和 调解分析。作为ECHO财团的一部分，充电团队将参与合成 队列结合了来自多个地点的儿童，这组研究集中在 协调未来UH3阶段的方案，并寻求分析回溯样品和 在可行的情况下，以协作方式提供数据。在UG3阶段，充值团队将制定协议、试点 重新接触和招募唾液与血液中的表观遗传学以及实施的试验方法 肾上腺激素研究，包括提高依从性的方法。充值的独特功能包括 有助于了解两种不同类型残疾儿童的生命过程发展，以及 肾上腺激素与性别性情感障碍关系的新模型。