Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children - Diversity Supplement

摘要-家长补助金 拟议的加州大学戴维斯分校ECHO再充电研究将跟踪一组最后一次看到的2-5岁儿童 （“基线”），以确定环境化学和非化学压力源和复原力因素， 与8-12岁（青春期前）和15-19岁（青春期中期）的神经发育结果相关 青春期晚期）。该项目利用了CHARGE（来自基因的儿童自闭症风险）的资源， 自2003年以来，该研究一直在招募三个年龄在2-5岁之间的群体： 自闭症谱系障碍（ASD），其他发育迟缓（DD）的儿童和一般儿童 典型发展人口（TD）。这三组，即ReCHARGE队列，将接受检查， 关注以下结果：注意力缺陷或多动症状;认知或适应性变化 功能;严重程度或诊断的变化;以及焦虑或抑郁症状。将进行试点测试 在UG 3阶段和UH 3阶段，所有人都将在青春期前或中晚期接受检查 青春期感兴趣的主要暴露是杀虫剂、金属、空气污染、邻苯二甲酸盐、营养素， 邻里特征和家庭因素。此外，提出了三个机制研究： 代际表观遗传学概况调查;干血中金属分析方法开发 斑点;以及肾上腺激素与抑郁症状的性别特异性关联。大约1400 家庭有资格再充电，提供了一个强大的样本检查的主要影响，相互作用， 调解分析。作为ECHO联盟的一部分，ReCHARGE团队将参与合成 来自多个地点的儿童组成的队列，以及集中在神经发育的一组研究， 协调前瞻性UH 3阶段的方案，并寻求分析回顾性样本， 在可行的情况下进行数据协作。在UG 3阶段，ReCHARGE团队将制定方案， 用于再接触和招募的测试方法，用于唾液与血液中的表观遗传学，以及用于实施 肾上腺激素研究，包括增加依从性的方法。ReCHARGE的独特功能包括 有助于了解患有两种不同类型残疾的儿童的生命历程发展，以及 肾上腺激素与性别特异性情感障碍关系的新模型

Abstract – Parent Grant The proposed UC Davis ECHO ReCHARGE Study will follow a cohort of children last seen at ages 2-5 years (`baseline') to determine environmental chemical and non-chemical stressors and resiliency factors that are associated with neurodevelopmental outcomes at ages 8-12 years (pre-adolescent) and 15-19 years (mid- to late adolescence). This project leverages the resources of the CHARGE (Childhood Autism Risks from Genes and Environment) Study, which, since 2003, has been enrolling three groups aged 2-5 years: children with autism spectrum disorder (ASD), children with other developmental delays (DD) and children from the general population with typical development (TD). These three groups, the ReCHARGE cohort, will be examined for the following outcomes of interest: attention deficit or hyperactivity symptoms; changes in cognitive or adaptive function; changes in severity or diagnosis; and symptoms of anxiety or depression. Pilot testing will take place in the UG3 phase, and in the UH3 phase, all will be examined either in pre-adolescence or mid- to late adolescence. The primary exposures of interest are pesticides, metals, air pollution, phthalates, nutrients, neighborhood characteristics, and family factors. Additionally, three mechanistic studies are proposed: an investigation of intergenerational epigenetic profiles; method development for metals analysis in dried blood spots; and sex specific associations of adrenal hormones with depressive symptoms. Approximately 1400 families are eligible for ReCHARGE, providing a robust sample for examination of main effects, interaction and mediation analyses. As part of the ECHO consortium, the ReCHARGE team will participate in the synthetic cohort combining children from multiple sites, and the cluster of studies focused on neurodevelopment in harmonizing protocols for the prospective UH3 phase and in seeking to analyze retrospective samples and data collaboratively, where feasible. During the UG3 phase, the ReCHARGE team will develop protocols, pilot test methods for recontacting and recruiting, for epigenetics in saliva vs. blood, and for implementation of the adrenal hormone study, including ways to increase compliance. Unique features of ReCHARGE include the contribution to understanding life course development in children with two different types of disabilities, and a novel model of adrenal hormone relationships with sex-specific affective disorders.