Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children - Diversity Supplement

CHARGE 研究儿童的青春期前和青春期后期随访 - 多样性补充

• 批准号: 10412853
• 负责人: Deborah Hall Bennett
• 金额: $ 6.65万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10412853
• 关键词: Adolescence; Adolescent; Adrenal hormone preparation; Age; Air Pollution; Attention deficit hyperactivity disorder; Attentional deficit; Blood; Characteristics; Chemicals; Child; Child Health; Childhood; Cognitive; Data; Development; Developmental Delay Disorders; Diagnosis; Diagnostic; Enrollment; Environment; Epigenetic Process; Family; General Population; Hyperactivity; Intervention; Investigation; Life Cycle Stages; Light; Mediation; Mental Depression; Metals; Methods; Modeling; Mood Disorders; Neighborhoods; Nutrient; Outcome; Pesticides; Phase; Protocols documentation; Recontacts; Resources; Saliva; Sampling; Severities; Site; Spottings; Symptoms; Testing; age group; anxiety symptoms; autism spectrum disorder; autistic children; cognitive performance; cohort; course development; depressive symptoms; disability; environmental chemical; follow-up; improved; interest; intergenerational; method development; neurodevelopment; novel; parent grant; phthalates; preadolescence; prospective; public health priorities; recruit; resilience; risk variant; sex; stressor

Abstract – Parent Grant The proposed UC Davis ECHO ReCHARGE Study will follow a cohort of children last seen at ages 2-5 years (`baseline') to determine environmental chemical and non-chemical stressors and resiliency factors that are associated with neurodevelopmental outcomes at ages 8-12 years (pre-adolescent) and 15-19 years (mid- to late adolescence). This project leverages the resources of the CHARGE (Childhood Autism Risks from Genes and Environment) Study, which, since 2003, has been enrolling three groups aged 2-5 years: children with autism spectrum disorder (ASD), children with other developmental delays (DD) and children from the general population with typical development (TD). These three groups, the ReCHARGE cohort, will be examined for the following outcomes of interest: attention deficit or hyperactivity symptoms; changes in cognitive or adaptive function; changes in severity or diagnosis; and symptoms of anxiety or depression. Pilot testing will take place in the UG3 phase, and in the UH3 phase, all will be examined either in pre-adolescence or mid- to late adolescence. The primary exposures of interest are pesticides, metals, air pollution, phthalates, nutrients, neighborhood characteristics, and family factors. Additionally, three mechanistic studies are proposed: an investigation of intergenerational epigenetic profiles; method development for metals analysis in dried blood spots; and sex specific associations of adrenal hormones with depressive symptoms. Approximately 1400 families are eligible for ReCHARGE, providing a robust sample for examination of main effects, interaction and mediation analyses. As part of the ECHO consortium, the ReCHARGE team will participate in the synthetic cohort combining children from multiple sites, and the cluster of studies focused on neurodevelopment in harmonizing protocols for the prospective UH3 phase and in seeking to analyze retrospective samples and data collaboratively, where feasible. During the UG3 phase, the ReCHARGE team will develop protocols, pilot test methods for recontacting and recruiting, for epigenetics in saliva vs. blood, and for implementation of the adrenal hormone study, including ways to increase compliance. Unique features of ReCHARGE include the contribution to understanding life course development in children with two different types of disabilities, and a novel model of adrenal hormone relationships with sex-specific affective disorders.

摘要 - 父母赠款 拟议的UC Davis Echo补给研究将跟随一群2-5岁的儿童队列 （“基线”）确定环境化学和非化学压力源和弹性因素是 与8-12岁的神经发育结局相关（前后）和15-19岁（中至15-19岁） 青少年晚期）。该项目利用了指控的资源（基因的儿童自闭症风险 和环境）研究，自2003年以来一直在招收2-5岁年龄的三组：患有 自闭症谱系障碍（ASD），其他发育延迟（DD）的儿童和一般儿童 具有典型发展的人群（TD）。这三组将检查补给队列 感兴趣的以下结果：注意力不足或多动症症状；认知或自适应的变化 功能;严重性或诊断的变化；和动画或抑郁的症状。试点测试将进行 在UG3阶段和UH3阶段，将在青春期或后期进行检查 青少年。感兴趣的主要暴露是农药，金属，空气污染，邻苯二甲酸盐，营养素， 邻里特征和家庭因素。此外，提出了三项机械研究： 代际表观遗传概况的投资；干血中金属分析的方法开发 斑点；以及具有抑郁症状的肾上腺的性别相关性。大约1400 家庭有资格获得充电，提供了一个可靠的样本，以检查主要影响，互动和 调解分析。作为回声财团的一部分，充值团队将参加合成 队列将来自多个地点的儿童结合在一起，研究集群着重于神经发育 协调前瞻性UH3阶段的协议，并试图分析回顾性样本和 数据合作，可行。在UG3阶段，充电团队将制定协议，飞行员 重新连接和招募的测试方法，唾液与血液中的表观遗传学以及实施 肾上腺犬研究，包括提高依从性的方法。充值的独特功能包括 对了解两种不同类型疾病的儿童的生活过程发展的贡献， 肾上腺马与性别特异性情感障碍的新型模型。