BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLES

建造弹珠：弹珠纵向数据共享的生物储存库维护和基础设施

• 批准号: 10202600
• 负责人: Deborah Hall Bennett
• 金额: $ 36.86万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2022-12-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202600
• 关键词: 2 year old; Address; Assessment tool; Biological Markers; Child; Child Development; Clinical; Clinical assessments; Coal; Cohort Studies; Data; Data Analyses; Data Collection; Diet; Early identification; Enrollment; Environmental Exposure; Environmental Health; Environmental Monitoring; Environmental Risk Factor; Epidemiology; Equipment and supply inventories; Etiology; Evaluation; Evaluation of Risk Factors; Freezing; Future; Gold; Immune; Infrastructure; Institutes; Investigation; Learning; Length; Life Style; Low Prevalence; Marble; Measurement; Measures; Mediator of activation protein; Medical History; Methylation; Molecular; Mothers; Neurodevelopmental Disorder; Nutrient; Outcome; Parents; Participant; Pathway interactions; Patient Self-Report; Population; Predisposition; Pregnancy; Prevalence; Protocols documentation; Reporting; Resource Sharing; Resources; Risk; Sample Size; Sampling; Serinus; Siblings; Specimen; Testing; Time; Update; Urine; Validity and Reliability; Variant; Visit; autism spectrum disorder; autistic children; biobank; clinical diagnostics; cohort; cost; data repository; data sharing; design; diagnosis standard; early life exposure; follow-up; high risk; improved; instrument; neurodevelopment; novel; population based; postnatal; prenatal; programs; prospective; recruit; repository; response; sample collection; study population

Abstract The MARBLES (Markers of Autism Risk in Babies: Learning Early Signs) Study was launched in 2006 by the UC Davis MIND Institute and Center for Children's Environmental Health as the first epidemiologic cohort of younger siblings of children with autism spectrum disorders (ASD) to begin follow-up during (and before) the prenatal period when ASD and other neurodevelopmental outcomes are likely to originate.1-7 In contrast to population-based cohorts, which require very large sample sizes given a relatively low prevalence of ASD (currently 1 in 68)8 and typically are not able to conduct gold standard diagnosis of ASD, the enriched risk design takes advantage of participants at exceptionally high risk for developing ASD and other neurodevelopmental outcomes, achieving tremendous efficiencies. Previous cohorts of high-risk younger siblings recruited postnatally have not addressed non-inherited and potentially modifiable etiologic factors.9 Early enrollment provides an opportunity to examine a broad array of environmental exposures and their mechanisms, while simultaneously allowing thorough search for early biologic markers.10 Given increasing prevalence of ASD,8,11 it is more critical now than ever to invest in studies identifying emerging environmental factors responsible for increasing risk of these neurodevelopmental disorders and the mechanisms underlying their etiology, which are currently not well-understood. This project addresses both gaps by maintaining and enhancing the resource infrastructure of the MARBLES enriched-risk cohort. Retention of this cohort with deep evaluation of risk factors, mechanistic markers, and outcomes will be critical to evaluation and early identification of newly emerging etiologic factors for ASD in a susceptible population, serving as a canary in a coal-mine for identifying exposures that influence neurodevelopment. Our cohort's data and specimens will permit analyses of new questions on exposures in relation to well-defined clinical neurodevelopmental outcomes, and our rich characterization of mechanistic biomarkers could identify pathways and signatures of susceptibility involved. We propose to continue to enroll and follow-up participants of one of the only enriched-risk ASD U.S. cohorts with prospectively collected pregnancy data and biosamples that is currently in no cost extension (NCE). In addition, we propose to further develop and maintain our repository infrastructure for the expansive data and sample repositories in order to expand collaborative sharing and facilitate investigation of newly-emerging environmental exposures and molecular mechanistic markers in relation to risk and presentation of ASD and other adverse neurodevelopmental conditions. Finally, we plan to validate and reliability test environmental exposure questions and measures for use in future studies. Completion of these aims will assist collaborative sharing of our vast collection of data and biosamples to facilitate investigation of newly-emerging environmental exposures and molecular mechanistic markers in relation to risk and presentation of ASD and other adverse neurodevelopmental conditions.

摘要

项目成果

COVID-19 Pandemic Experiences and Symptoms of Pandemic-Associated Traumatic Stress Among Mothers in the US.

美国母亲之间大流行相关的创伤应激的大流行经历和症状。

• DOI: 10.1001/jamanetworkopen.2022.47330
• 发表时间: 2022-12-01
• 期刊: JAMA NETWORK OPEN
• 影响因子: 13.8
• 作者: Bastain, Theresa M.;Knapp, Emily A.;Law, Andrew;Algermissen, Molly;Avalos, Lyndsay A.;Birnhak, Zoe;Blackwell, Courtney;Breton, Carrie, V;Duarte, Cristiane;Frazier, Jean;Ganiban, Jody;Greenwood, Paige;Herbstman, Julie;Hernandez-Castro, Ixel;Hofheimer, Julie;Karagas, Margaret R.;Lewis, Johnnye;Pagliaccio, David;Ramphal, Bruce;Saxbe, Darby;Schmidt, Rebecca;Velez-Vega, Carmen;Tang, Xiaodan;Hamra, Ghassan B.;Margolis, Amy
• 通讯作者: Margolis, Amy

Gestational Vitamin D and Autism Spectrum Disorder.

妊娠维生素 D 和自闭症谱系障碍。

• DOI: 10.1016/j.biopsych.2021.09.014
• 发表时间: 2021
• 期刊: Biological psychiatry
• 影响因子: 10.6
• 作者: Schmidt,RebeccaJ

Maternal polyunsaturated fatty acids and risk for autism spectrum disorder in the MARBLES high-risk study.

• DOI: 10.1177/1362361319877792
• 发表时间: 2020-07
• 期刊: AUTISM
• 影响因子: 5.2
• 作者: Huang, Yunru;Iosif, Ana-Maria;Hansen, Robin L.;Schmidt, Rebecca J.
• 通讯作者: Schmidt, Rebecca J.

Assessing Repeated Urinary Proline Betaine Measures as a Biomarker of Usual Citrus Intake during Pregnancy: Sources of Within-Person Variation and Correlation with Reported Intake.

• DOI: 10.3390/metabo13080904
• 发表时间: 2023-08-02
• 期刊: Metabolites
• 影响因子: 4.1

Examining Prenatal Dietary Factors in Association with Child Autism-Related Traits Using a Bayesian Mixture Approach: Results from 2 United States Cohorts.

• DOI: 10.1016/j.cdnut.2023.101978
• 发表时间: 2023-08
• 期刊: CURRENT DEVELOPMENTS IN NUTRITION
• 影响因子: 4.8
• 作者: Lyall, Kristen;Rando, Juliette;Wang, Siwen;Hamra, Ghassan B;Chavarro, Jorge;Weisskopf, Marc G;Croen, Lisa A;Fallin, M Daniele;Hertz-Picciotto, Irva;Volk, Heather E;Schmidt, Rebecca J;Newschaffer, Craig J
• 通讯作者: Newschaffer, Craig J