BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLES
建造弹珠:弹珠纵向数据共享的生物储存库维护和基础设施
基本信息
- 批准号:10202600
- 负责人:
- 金额:$ 36.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-30 至 2022-12-25
- 项目状态:已结题
- 来源:
- 关键词:2 year oldAddressAssessment toolBiological MarkersChildChild DevelopmentClinicalClinical assessmentsCoalCohort StudiesDataData AnalysesData CollectionDietEarly identificationEnrollmentEnvironmental ExposureEnvironmental HealthEnvironmental MonitoringEnvironmental Risk FactorEpidemiologyEquipment and supply inventoriesEtiologyEvaluationEvaluation of Risk FactorsFreezingFutureGoldImmuneInfrastructureInstitutesInvestigationLearningLengthLife StyleLow PrevalenceMarbleMeasurementMeasuresMediator of activation proteinMedical HistoryMethylationMolecularMothersNeurodevelopmental DisorderNutrientOutcomeParentsParticipantPathway interactionsPatient Self-ReportPopulationPredispositionPregnancyPrevalenceProtocols documentationReportingResource SharingResourcesRiskSample SizeSamplingSerinusSiblingsSpecimenTestingTimeUpdateUrineValidity and ReliabilityVariantVisitautism spectrum disorderautistic childrenbiobankclinical diagnosticscohortcostdata repositorydata sharingdesigndiagnosis standardearly life exposurefollow-uphigh riskimprovedinstrumentneurodevelopmentnovelpopulation basedpostnatalprenatalprogramsprospectiverecruitrepositoryresponsesample collectionstudy population
项目摘要
Abstract
The MARBLES (Markers of Autism Risk in Babies: Learning Early Signs) Study was launched in 2006 by
the UC Davis MIND Institute and Center for Children's Environmental Health as the first epidemiologic cohort
of younger siblings of children with autism spectrum disorders (ASD) to begin follow-up during (and before) the
prenatal period when ASD and other neurodevelopmental outcomes are likely to originate.1-7 In contrast to
population-based cohorts, which require very large sample sizes given a relatively low prevalence of ASD
(currently 1 in 68)8 and typically are not able to conduct gold standard diagnosis of ASD, the enriched risk
design takes advantage of participants at exceptionally high risk for developing ASD and other
neurodevelopmental outcomes, achieving tremendous efficiencies. Previous cohorts of high-risk younger
siblings recruited postnatally have not addressed non-inherited and potentially modifiable etiologic factors.9
Early enrollment provides an opportunity to examine a broad array of environmental exposures and their
mechanisms, while simultaneously allowing thorough search for early biologic markers.10
Given increasing prevalence of ASD,8,11 it is more critical now than ever to invest in studies identifying
emerging environmental factors responsible for increasing risk of these neurodevelopmental disorders and the
mechanisms underlying their etiology, which are currently not well-understood. This project addresses both
gaps by maintaining and enhancing the resource infrastructure of the MARBLES enriched-risk cohort.
Retention of this cohort with deep evaluation of risk factors, mechanistic markers, and outcomes will be critical
to evaluation and early identification of newly emerging etiologic factors for ASD in a susceptible population,
serving as a canary in a coal-mine for identifying exposures that influence neurodevelopment. Our cohort's
data and specimens will permit analyses of new questions on exposures in relation to well-defined clinical
neurodevelopmental outcomes, and our rich characterization of mechanistic biomarkers could identify
pathways and signatures of susceptibility involved. We propose to continue to enroll and follow-up participants
of one of the only enriched-risk ASD U.S. cohorts with prospectively collected pregnancy data and biosamples
that is currently in no cost extension (NCE). In addition, we propose to further develop and maintain our
repository infrastructure for the expansive data and sample repositories in order to expand collaborative
sharing and facilitate investigation of newly-emerging environmental exposures and molecular mechanistic
markers in relation to risk and presentation of ASD and other adverse neurodevelopmental conditions. Finally,
we plan to validate and reliability test environmental exposure questions and measures for use in future
studies. Completion of these aims will assist collaborative sharing of our vast collection of data and biosamples
to facilitate investigation of newly-emerging environmental exposures and molecular mechanistic markers in
relation to risk and presentation of ASD and other adverse neurodevelopmental conditions.
摘要
项目成果
期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
COVID-19 Pandemic Experiences and Symptoms of Pandemic-Associated Traumatic Stress Among Mothers in the US.
美国母亲之间大流行相关的创伤应激的大流行经历和症状。
- DOI:10.1001/jamanetworkopen.2022.47330
- 发表时间:2022-12-01
- 期刊:
- 影响因子:13.8
- 作者:Bastain, Theresa M.;Knapp, Emily A.;Law, Andrew;Algermissen, Molly;Avalos, Lyndsay A.;Birnhak, Zoe;Blackwell, Courtney;Breton, Carrie, V;Duarte, Cristiane;Frazier, Jean;Ganiban, Jody;Greenwood, Paige;Herbstman, Julie;Hernandez-Castro, Ixel;Hofheimer, Julie;Karagas, Margaret R.;Lewis, Johnnye;Pagliaccio, David;Ramphal, Bruce;Saxbe, Darby;Schmidt, Rebecca;Velez-Vega, Carmen;Tang, Xiaodan;Hamra, Ghassan B.;Margolis, Amy
- 通讯作者:Margolis, Amy
Gestational Vitamin D and Autism Spectrum Disorder.
妊娠维生素 D 和自闭症谱系障碍。
- DOI:10.1016/j.biopsych.2021.09.014
- 发表时间:2021
- 期刊:
- 影响因子:10.6
- 作者:Schmidt,RebeccaJ
- 通讯作者:Schmidt,RebeccaJ
Maternal polyunsaturated fatty acids and risk for autism spectrum disorder in the MARBLES high-risk study.
- DOI:10.1177/1362361319877792
- 发表时间:2020-07
- 期刊:
- 影响因子:5.2
- 作者:Huang, Yunru;Iosif, Ana-Maria;Hansen, Robin L.;Schmidt, Rebecca J.
- 通讯作者:Schmidt, Rebecca J.
Assessing Repeated Urinary Proline Betaine Measures as a Biomarker of Usual Citrus Intake during Pregnancy: Sources of Within-Person Variation and Correlation with Reported Intake.
- DOI:10.3390/metabo13080904
- 发表时间:2023-08-02
- 期刊:
- 影响因子:4.1
- 作者:
- 通讯作者:
Examining Prenatal Dietary Factors in Association with Child Autism-Related Traits Using a Bayesian Mixture Approach: Results from 2 United States Cohorts.
- DOI:10.1016/j.cdnut.2023.101978
- 发表时间:2023-08
- 期刊:
- 影响因子:4.8
- 作者:Lyall, Kristen;Rando, Juliette;Wang, Siwen;Hamra, Ghassan B;Chavarro, Jorge;Weisskopf, Marc G;Croen, Lisa A;Fallin, M Daniele;Hertz-Picciotto, Irva;Volk, Heather E;Schmidt, Rebecca J;Newschaffer, Craig J
- 通讯作者:Newschaffer, Craig J
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Deborah Hall Bennett其他文献
Deborah Hall Bennett的其他文献
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{{ truncateString('Deborah Hall Bennett', 18)}}的其他基金
The CHARGE Study Phase II: A Multifactorial Approach to Autism Etiology
CHARGE 研究第二阶段:自闭症病因学的多因素方法
- 批准号:
10153782 - 财政年份:2020
- 资助金额:
$ 36.86万 - 项目类别:
The CHARGE Study Phase II: A Multifactorial Approach to Autism Etiology
CHARGE 研究第二阶段:自闭症病因学的多因素方法
- 批准号:
10343808 - 财政年份:2020
- 资助金额:
$ 36.86万 - 项目类别:
Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and Adolescence
重温 ReCHARGE:ECHO 对童年中期和青春期的跟进
- 批准号:
10745252 - 财政年份:2016
- 资助金额:
$ 36.86万 - 项目类别:
Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children
CHARGE 研究儿童的青春期前和青春期后期随访
- 批准号:
10240314 - 财政年份:2016
- 资助金额:
$ 36.86万 - 项目类别:
Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children - Diversity Supplement
CHARGE 研究儿童的青春期前和青春期后期随访 - 多样性补充
- 批准号:
10412853 - 财政年份:2016
- 资助金额:
$ 36.86万 - 项目类别:
Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children
CHARGE 研究儿童的青春期前和青春期后期随访
- 批准号:
10675376 - 财政年份:2016
- 资助金额:
$ 36.86万 - 项目类别:
Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children
CHARGE 研究儿童的青春期前和青春期后期随访
- 批准号:
10470815 - 财政年份:2016
- 资助金额:
$ 36.86万 - 项目类别:
Pre-adolescent and Late-adolescent Follow-up of the CHARGE Study Children
CHARGE 研究儿童的青春期前和青春期后期随访
- 批准号:
10013293 - 财政年份:2016
- 资助金额:
$ 36.86万 - 项目类别:
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