Exposure Core

项目摘要-暴露核心 可靠的暴露评估是任何环境流行病学或毒理学项目成功的关键 确定暴露可能是复杂的，因为人们通过多种途径接触多种化合物， 暴露途径。在最初的融资期间，Exposure Core已成为一个知名的 寻求关于研究设计的暴露相关部分的建议，并开发新的和有用的 促进环境卫生研究的方法和设施。The Exposure曝光Core核心has helped帮助connect连接 调查人员与分析实验室，可以帮助进一步他们的接触特性，协助 流行病学家采用稳健的暴露评估设计，并协助毒理学家量化暴露， 将它们与相关基准或组织水平相关联。对于多种化学品的情况，核心有助于确保 实验室暴露模拟真实世界的人类暴露情景。曝光的首要目标是 核心是提供全面的暴露研究设计和分析专业知识，以提高 需要对流行病学研究进行接触评估的研究和 毒理学研究，从而提高在加州大学戴维斯分校进行的环境健康研究的质量。 核心实验室包括以下方面的专门知识：1）对有机化合物进行目标和非目标分析， 环境和生物样本，2）时间积分或时间窗特定接触浓度，3） 环境样品的成分分析，通过FTIR和质谱确定有机功能 通过XRF和ICPMS分析的光谱和元素和同位素，4）动物设计指南 一系列空气污染物和来源的吸入毒理学研究，5）帮助环境保护的资源 司法界确定潜在的暴露，一个与交通有关的空气传播颗粒的暴露动物园， 以及5）便携式野火测量系统。核心成员继续扩大其实验室的能力 以满足中心成员日益增长的需求。核心是提高我们帮助教师的能力 与社区团体合作，评估令人关切的化合物，并制定简化的方法， 评估社区暴露。曝光核心已经制定了一个计划，提供种子资金， 研究人员进行方法开发，以建立能力。Exposure Core还提供两种补贴 以及为中心成员在核心实验室进行样本分析提供种子资金。我们提供咨询， 通过由行政核心主持的特定目标审查，通过暴露设计， 审查潜在的试点申请人，并通过与调查人员的会议。通过提供曝光 作为综合核心的一部分，而不是通过独立的校园，向调查人员提供评估专业知识 实验室，我们将能够提供一个更强大的，适当的，定制的曝光 通过我们的协同作用，互动和合作进行评估。

PROJECT SUMMARY – Exposure Core A robust exposure assessment is key to the success of any environmental epidemiology or toxicology project and determining exposure can be complex as people are exposed to multiple compounds through multiple exposure pathways. During the initial funding period, the Exposure Core has become a well-known hub on campus for seeking advice on the exposure related portion of study design and for developing new and helpful methods and facilities to further environmental health research. The Exposure Core has helped connect investigators with analytical laboratories that can help further their exposure characterization, assisted epidemiologists with robust exposure assessment design, and aided toxicologists to quantify exposures and relate them to a relevant benchmark or tissue level. For multi-chemical scenarios, The Core has helped ensure that laboratory exposures model real-world human exposure scenarios. The overarching goal of the Exposure Core is to provide comprehensive exposure study design and analysis expertise to improve the quality of studies that require exposure assessment for epidemiological studies and exposure environments for toxicological studies, and hence improve the quality of environmental health research conducted at UC Davis. Exposure Core laboratories include expertise in: 1) target and non-target analysis of organic compounds in environmental and biological samples, 2) time-integrated or time-window specific exposure concentrations, 3) compositional analysis of environmental samples to identify organic functionality via FTIR and mass spectrometry and elements and isotopes via XRF and ICPMS analysis, 4) design guidance for animal inhalation toxicology studies from a range of air pollutants and sources, 5) resources for helping environmental justice communities determine potential exposures, an exposure vivarium for traffic related airborne particles, and 5) a portable wildfire measurement system. Core members continue to expand the capabilities of their labs to meet these growing needs of center members. The core is increasing our capabilities in helping faculty working with community groups to evaluate compounds of concern and develop streamlined methods for evaluating community exposures. The Exposure Core has developed a program to provide seed funding to investigators for method development to build capabilities. The Exposure Core also provides both subsidies and seed funding for sample analysis in the core laboratories for center members. We provide advice on the study design through Specific Aims Reviews hosted by the Administrative Core, through Exposure Design Reviews for potential pilot applicants, and through meetings with investigators. By providing exposure assessment expertise to investigators as part of an integrated core, rather than via independent campus laboratories, we will be able to provide a much more robust, appropriate, and custom tailored exposure assessment through our synergies, interactions and collaborations.