Exposure Core

曝光核心

• 批准号: 10388389
• 负责人: Deborah Hall Bennett
• 金额: $ 8.5万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-05 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10388389
• 关键词: Address; Air Pollutants; Animals; Applications Grants; Benchmarking; Biological; Biometry; Chemicals; Clinic; Collaborations; Communities; Complex; Custom; Data; Data Analyses; Dust; Elements; Engineering; Ensure; Environment; Environmental Epidemiology; Environmental Health; Epidemiologist; Epidemiology; Exposure to; Faculty; Funding; Goals; Grant; Human Milk; Human Resources; Inhalation Toxicology; Isotopes; Laboratories; Leadership; Mass Spectrum Analysis; Measurement; Methods; Modeling; Persons; Preparation; Research; Research Design; Research Personnel; Resources; Sampling; Scientist; Seeds; Source; Specific qualifier value; Spectroscopy, Fourier Transform Infrared; System; Techniques; Time; Tissues; Toxicology; Toxin; Wildfire; Work; cost effective; design; environmental justice; environmental toxicology; epidemiology study; exposed human population; exposure pathway; improved; interest; meetings; member; method development; multidisciplinary; particle; portability; programs; recruit; success; synergism

PROJECT SUMMARY – Exposure Core A robust exposure assessment is key to the success of any environmental epidemiology or toxicology project and determining exposure can be complex as people are exposed to multiple compounds through multiple exposure pathways. During the initial funding period, the Exposure Core has become a well-known hub on campus for seeking advice on the exposure related portion of study design and for developing new and helpful methods and facilities to further environmental health research. The Exposure Core has helped connect investigators with analytical laboratories that can help further their exposure characterization, assisted epidemiologists with robust exposure assessment design, and aided toxicologists to quantify exposures and relate them to a relevant benchmark or tissue level. For multi-chemical scenarios, The Core has helped ensure that laboratory exposures model real-world human exposure scenarios. The overarching goal of the Exposure Core is to provide comprehensive exposure study design and analysis expertise to improve the quality of studies that require exposure assessment for epidemiological studies and exposure environments for toxicological studies, and hence improve the quality of environmental health research conducted at UC Davis. Exposure Core laboratories include expertise in: 1) target and non-target analysis of organic compounds in environmental and biological samples, 2) time-integrated or time-window specific exposure concentrations, 3) compositional analysis of environmental samples to identify organic functionality via FTIR and mass spectrometry and elements and isotopes via XRF and ICPMS analysis, 4) design guidance for animal inhalation toxicology studies from a range of air pollutants and sources, 5) resources for helping environmental justice communities determine potential exposures, an exposure vivarium for traffic related airborne particles, and 5) a portable wildfire measurement system. Core members continue to expand the capabilities of their labs to meet these growing needs of center members. The core is increasing our capabilities in helping faculty working with community groups to evaluate compounds of concern and develop streamlined methods for evaluating community exposures. The Exposure Core has developed a program to provide seed funding to investigators for method development to build capabilities. The Exposure Core also provides both subsidies and seed funding for sample analysis in the core laboratories for center members. We provide advice on the study design through Specific Aims Reviews hosted by the Administrative Core, through Exposure Design Reviews for potential pilot applicants, and through meetings with investigators. By providing exposure assessment expertise to investigators as part of an integrated core, rather than via independent campus laboratories, we will be able to provide a much more robust, appropriate, and custom tailored exposure assessment through our synergies, interactions and collaborations.

项目摘要 - 曝光核心 强大的暴露评估是任何环境流行病学或毒理学项目成功的关键 当人们通过多种暴露于多种化合物时，确定暴露可能很复杂 曝光途径。在最初的资金期间，曝光核心已成为众所周知的枢纽 校园，以寻求有关研究设计相关部分的建议，并开发新的和有益的建议 进一步环境健康研究的方法和设施。曝光核心有助于连接 研究人员的分析实验室可以帮助进一步的暴露表征，辅助 具有强大暴露评估设计的流行病学家，并有助于毒理学家量化暴露和 将它们与相关的基准或组织水平联系起来。对于多化学方案，核心有助于确保 该实验室暴露于现实世界中的人类暴露情况。暴露的总体目标 核心是提供全面的接触研究设计和分析专业知识，以提高 需要对流行病学研究和暴露环境进行暴露评估的研究 毒理学研究，因此提高了加州大学戴维斯分校进行的环境健康研究的质量。 暴露核心实验室包括：1）有机化合物的目标和非目标分析 环境和生物学样本，2）时间集成或时间范围的特定暴露浓度，3） 环境样品的组成分析，通过FTIR和质量识别有机功能 通过XRF和ICPMS分析，光谱和元素和同位素，4）动物设计指南 吸入毒理学研究来自一系列空气污染物和来源，5）帮助环境的资源 司法社区确定潜在的暴露，是与交通相关的空中颗粒的曝光， 5）便携式野火测量系统。核心成员继续扩大实验室的功能 满足中心成员不断增长的需求。核心正在提高我们帮助教师的能力 与社区团体合作评估关注的化合物并开发精简方法 评估社区的暴露。曝光核心已经开发了一个计划，以提供种子资金 方法开发的研究人员建立功能。曝光核心还提供两种补贴 以及用于中心成员核心实验室样本分析的种子资金。我们提供有关 通过行政核心主持的特定目标评论进行研究设计，通过曝光设计 对潜在的试点申请人的审查，以及与调查人员的会议。通过提供曝光 作为综合核心的一部分，对研究人员的评估专业知识，而不是通过独立校园 实验室，我们将能够提供更健壮，适当且定制的曝光 通过我们的协同，互动和协作进行评估。